生物医药

化学生物学

RSK2激酶抑制剂;构效关系;分子对接;苯甲酰肼衍生物

Systematic Review;Molecular Docking;Maternal Obesity;Lipogenesis;Histone Methylation;Er Stress;Nafld;SAR;Acupuncture;Virtual Screening

1. Prediction of Drug-Target Interactions and Drug Repositioning Via Network-Based Inference
Feixiong Cheng; Chuang Liu; Jing Jiang; Weiqiang Lu; Weihua Li; Guixia Liu; Weixing Zhou; Jin Huang; Yun Tang
PLoS Computational Biology, 2012

2. Effectiveness of N95 Respirators Versus Surgical Masks Against Influenza: A Systematic Review and Meta‐analysis
Youlin Long; Tengyue Hu; Liqin Liu; Rui Chen; Qiong Guo; Liu Yang; Yifan Cheng; Jin Huang; Liang Du
JOURNAL OF EVIDENCE BASED MEDICINE, 2020

3. Core Outcomes Were Rarely Reported Overall in Systematic Reviews on Acupuncture for Osteoarthritis: a Cross-Sectional Meta-Epidemiological Study.
Tengyue Hu; Youlin Long; Rui Chen; Zixin Yang; Liqin Liu; Litao Huang; Jin Huang; Ga Liao; Liang Du
ACUPUNCTURE IN MEDICINE, 2023

4. Target Identification among Known Drugs by Deep Learning from Heterogeneous Networks
Xiangxiang Zeng; Siyi Zhu; Weiqiang Lu; Zehui Liu; Jin Huang; Yadi Zhou; Jiansong Fang; Yin Huang; Huimin Guo; Lang Li; Bruce D. Trapp; Ruth Nussinov; Charis Eng; Joseph Loscalzo; Feixiong Cheng
SSRN Electronic Journal, 2019

5. A Genome-Wide Positioning Systems Network Algorithm for in Silico Drug Repurposing
Feixiong Cheng; Weiqiang Lu; Chuang Liu; Jiansong Fang; Yuan Hou; Diane E. Handy; Ruisheng Wang; Yuzheng Zhao; Yi Yang; Jin Huang; David E. Hill; Marc Vidal; Charis Eng; Joseph Loscalzo
Nature Communications, 2019

6. Accumulation of Endoplasmic Reticulum Stress and Lipogenesis in the Liver Through Generational Effects of High Fat Diets.
Jiong Li; Jin Huang; Jian-Shuang Li; Hong Chen; Kun Huang; Ling Zheng
JOURNAL OF HEPATOLOGY, 2012

7. Comprehensive Characterization of Protein–protein Interactions Perturbed by Disease Mutations
Feixiong Cheng; Junfei Zhao; Yang Wang; Weiqiang Lu; Zehui Liu; Yadi Zhou; William R. Martin; Ruisheng Wang; Jin Huang; Tong Hao; Hong Yue; Jing Ma; Yuan Hou; Jessica A. Castrillon; Jiansong Fang
Nature Genetics, 2021

8. Coexistence of Long-Range Ferromagnetic Ordering and Glassy Behavior in One-Dimensional Bimetallic Cyano-Bridged Polymers
DF Li; LM Zheng; YZ Zhang; J Huang; S Gao; WX Tang
INORGANIC CHEMISTRY, 2003

9. Syntheses, Structures, and Properties of Imidazolate-Bridged Cu(Ii)-Cu(Ii) and Cu(Ii)-Zn(Ii) Dinuclear Complexes of A Single Macrocyclic Ligand with Two Hydroxyethyl Pendants
DF Li; S Li; DX Yang; JH Yu; J Huang; YZ Li; WX Tang
Inorganic Chemistry, 2003

10. Discovering Potent Small Molecule Inhibitors of Cyclophilin A Using De Novo Drug Design Approach
Shuaishuai Ni; Yaxia Yuan; Jin Huang; Xiaona Mao; Maosheng Lv; Jin Zhu; Xu Shen; Jianfeng Pei; Luhua Lai; Hualiang Jiang; Jian Li
JOURNAL OF MEDICINAL CHEMISTRY, 2009

1. 基于HiBiT技术的NRF2降解剂的筛选体系、表达载体、宿主细胞及方法
华东理工大学
黄瑾; 卢伟强; 倪子雲
公开日期: 2024-05-07 申请日期: 2022-11-04 公开号: CN117986377A

2. 用于NRF2/PPIA界面抑制剂筛选体系、表达载体、宿主细胞及方法
华东理工大学
黄瑾; 卢伟强; 许昭敏; 刘茜; 倪子雲
公开日期: 2024-05-07 申请日期: 2022-11-02 公开号: CN117986373A

3. 胡椒碱及其衍生物在制备治疗自身免疫性疾病的药物中的应用
华东理工大学
黄瑾; 卢伟强; 刘泽慧; 马磊
公开日期: 2020-06-12 申请日期: 2020-02-28 公开号: CN111265515A

4. 一种具有DHODH抑制活性的含N、S杂环化合物及其制备和用途
华东理工大学
徐晓勇; 李春燕; 黄瑾; 李洪林; 李忠; 李婷芳
公开日期: 2018-11-30 申请日期: 2013-01-31 公开号: CN103965133B

5. 补骨脂乙素在制备急性髓细胞性白血病治疗药物中的应用
华东理工大学
黄瑾; 黄莹; 卢伟强; 付志敏; 吴荡; 梁宏
公开日期: 2018-01-19 申请日期: 2017-11-03 公开号: CN107595825A

6. 种具有光催化性能的凹凸棒石‑类石墨相氮化碳复合陶瓷微滤膜及其制备方法和应用
HUAIYIN TEACHER COLLEGE
XUE AILIAN; ZHOU SHOUYONG; ZHAO YIJIANG; WEI DONGYANG; LI MEISHENG; XING WEIHONG; WU FEIYUE; ZHANG LILI; CHU XIAOZHONG; ZHANG YAN; HUANG JIN
公开日期: 2017-08-04 申请日期: 2017-04-13 公开号: CN107008152A

7. 种具有光催化性能的凹凸棒石‑类石墨相氮化碳复合中空纤维微滤膜及其制备方法和应用
HUAIYIN TEACHER COLLEGE
ZHANG YAN; FAN ZHAORU; ZHANG LILI; ZHAO YIJIANG; WU FEIYUE; ZHOU SHOUYONG; XING WEIHONG; HUANG JIN; XUE AILIAN; LI MEISHENG; CHU XIAOZHONG
公开日期: 2017-07-14 申请日期: 2017-04-13 公开号: CN106943890A

8. N‑(4‑取代苯乙基)乙酰胺类化合物及其用途
华东理工大学
朱进; 黄瑾; 陈文华; 姚雪; 凌大正; 王曼炯; 蒋华良; 李剑
公开日期: 2017-07-11 申请日期: 2017-01-17 公开号: CN106938997A

9. 乙酰胺类化合物及其用途
UNIV EAST CHINA SCIENCE & TECH
ZHU JIN; HUANG JIN; CHEN WENHUA; YAO XUE; LING DAZHENG; WANG MANJIONG; JIANG HUALIANG; LI JIAN
公开日期: 2017-06-30 申请日期: 2017-01-17 公开号: CN106905247A

10. 种凹凸棒石‑类石墨相氮化碳‑聚偏氟乙烯纳米复合超滤膜及其制备方法和应用
HUAIYIN TEACHER COLLEGE
ZHOU SHOUYONG; XUE AILIAN; ZHAO YIJIANG; ZHAO DAN; LI MEISHENG; YANG YU; ZHANG YAN; XING WEIHONG; WU FEIYUE; ZHANG LILI; CHU XIAOZHONG; HUANG JIN
公开日期: 2017-06-30 申请日期: 2017-04-13 公开号: CN106902638A

11. 取代脲类小分子亲环素A抑制剂新型抗癌用途
华东理工大学
李剑; 黄瑾; 闫文仲; 李蹊
公开日期: 2016-02-17 申请日期: 2015-09-23 公开号: CN105326821A

12. 苯并三氮唑衍生物做为RSK2抑制剂的合成及应用
UNIV EAST CHINA SCIENCE & TECH
YUFANG XU; ZHENJIANG ZHAO; XIAOFENG LIU; JIN HUANG; HONGLIN LI; YE ZHONG; WEIQIANG LU; XIANWEN CAO; KANGDONG LIU
公开日期: 2016-02-17 申请日期: 2011-03-21 公开号: CN102688233B

13. 苯并咪唑、噁唑和噻唑衍生物的合成及其应用
华东理工大学
李洪林; 赵振江; 刘晓峰; 黄瑾; 徐玉芳; 薛梦竹; 袁俊; 崔雷; 曹贤文; 吴彬; 韩乐
公开日期: 2015-07-15 申请日期: 2011-01-31 公开号: CN102617478B

14. 作为法尼基转移酶抑制剂的苯胺类化合物及其用途
华东理工大学
徐玉芳; 李洪林; 赵振江; 黄瑾; 杨柳清; 陈甜甜; 赵雪; 梅寒冰; 张媛
公开日期: 2015-05-27 申请日期: 2014-02-17 公开号: CN103787907B

15. Preparation method and adsorption method of Ni<2+> adsorbent
HUAIYIN TEACHER COLLEGE
XU JIMING; XIANG XINXIN; WU ZHEN; HUANG JIN
公开日期: 2014-12-24 申请日期: 2014-09-15 公开号: CN104226238A

16. New pentabasic dihydrogen heterocyclic ketone derivative useful in pharmaceutical composition and preparation of medicines for preventing and/or treating diseases e.g. parasitic diseases and rheumatoid arthritis.
UNIV EAST CHINA SCIENCE & TECH
LI HONGLIN; HUANG JIN; XU YUFANG; ZHAO ZHENJIANG; XU MINGHAO; DIAO YANYAN; ZHOU HONGCHANG; JIN HUANGTAO; GAO RUI; ZHU JUNSHENG
公开日期: 2014-10-23 申请日期: 2012-11-14 公开号: DE112012004878T8

17. 哌嗪二酮衍生物及其制备和用途
华东理工大学
宋恭华; 孙海洋; 王佳毅; 黄瑾; 李晖; 张小灵
公开日期: 2014-10-15 申请日期: 2014-08-01 公开号: CN104098549A

18. Method for treatment of malaria
ZHANG WEIDONG; HUANG JIN; SHAN LEI; LI HONGLIN; WANG LIYAN; ZHANG SHOUDE; LU WEIQIANG; SU JUAN; CHEN TONG; UNIV PLA 2ND MILITARY MEDICAL; UNIV EAST CHINA SCIENCE & TECH
ZHANG WEIDONG; HUANG JIN; SHAN LEI; LI HONGLIN; WANG LIYAN; ZHANG SHOUDE; LU WEIQIANG; SU JUAN; CHEN TONG
公开日期: 2014-09-30 申请日期: 2012-04-23 公开号: US8846627B2

19. Method for treatment of malaria
Weidong Zhang; Jin Huang; Lei Shan; Honglin Li; Liyan Wang; Shoude Zhang; Weiqiang Lu; Juan Su; Tong Chen
Weidong Zhang; Jin Huang; Lei Shan; Honglin Li; Liyan Wang; Shoude Zhang; Weiqiang Lu; Juan Su; Tong Chen
公开日期: 2014-09-30 申请日期: 2012-04-23 公开号: US08846627B2

20. Thiazole derivative as DHODH inhibitor and use thereof
UNIV EAST CHINA SCIENCE & TECH
ZHAO ZHENJIANG; HUANG JIN; LI HONGLIN; XU YUFANG; ZHU LILI; HAN LE; XU MINGHAO; GAO RUI; DIAO YANYAN; ZHU JUNSHENG; CAO XIANWEN; CUI KUNQIANG
公开日期: 2014-08-20 申请日期: 2012-12-18 公开号: CN103998434A

1. 靶向Fp-2天然抗疟活性化合物ZWD1024作用机理研究
立项时间: 2012-2014 项目经费：230000

2. 药用仪器分析掌上自学平台的设计与构建
立项时间: 2023

3. PPIA/MTHFD2信号促进结直肠癌发生发展的作用机制及小分子干预研究
立项时间: 2023

4. FLT3 - ITD /DHODH信号通路调控白血病嘧啶代谢的作用机理研究
立项时间: 2020-2023

5. CypA/Nrf2复合物在非小细胞肺癌氨基酸代谢异常中的作用、机理研究及靶向药物发现
立项时间: 2018-2021

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