生物医药

药物化学和新药研发

抗肿瘤活性;综述;药物化学;合成;天然产物;高喜树碱;化学合成;抗肿瘤;工艺改进;紫红素-18

Antitumor Activity;Homocamptothecin;Camptothecin;Drug Design;Topoisomerase I;Antifungal Activity;Synthesis;Molecular Docking;Antifungal;Biological Activity

1. Chalcone: A Privileged Structure in Medicinal Chemistry
Chunlin Zhuang; Wen Zhang; Chunquan Sheng; Wannian Zhang; Chengguo Xing; Zhenyuan Miao
CHEMICAL REVIEWS, 2017

2. Structure-Based Optimization of Azole Antifungal Agents by CoMFA, CoMSIA, and Molecular Docking
CQ Sheng; WN Zhang; HT Ji; M Zhang; YL Song; H Xu; J Zhu; ZY Miao; QF Jiang; JZ Yao; YJ Zhou; JG Lu
JOURNAL OF MEDICINAL CHEMISTRY, 2006

3. Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents.
Shengzheng Wang; Kun Fang; Guoqiang Dong; Shuqiang Chen; Na Liu; Zhenyuan Miao; Jianzhong Yao; Jian Li; Wannian Zhang; Chunquan Sheng
Journal of Medicinal Chemistry, 2015

4. New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives As Novel Antitumor Agents by Systemic Structure-Activity Relationship Analysis and Biological Evaluations.
Guoqiang Dong; Shengzheng Wang; Zhenyuan Miao; Jianzhong Yao; Yongqiang Zhang; Zizhao Guo; Wannian Zhang; Chunquan Sheng
Journal of Medicinal Chemistry, 2012

5. Selection of Evodiamine As a Novel Topoisomerase I Inhibitor by Structure-Based Virtual Screening and Hit Optimization of Evodiamine Derivatives As Antitumor Agents.
Guoqiang Dong; Chunquan Sheng; Shengzheng Wang; Zhenyuan Miao; Jianzhong Yao; Wannian Zhang
Journal of Medicinal Chemistry, 2010

6. State-of-the-art Strategies for Targeting Protein-Protein Interactions by Small-Molecule Inhibitors.
Chunquan Sheng; Guoqiang Dong; Zhenyuan Miao; Wannian Zhang; Wei Wang
CHEMICAL SOCIETY REVIEWS, 2015

7. Small molecule-drug conjugates: A novel strategy for cancer-targeted treatment
Chunlin Zhuang; Xianghong Guan; Hao Ma; Hui Cong; Wannian Zhang; Zhenyuan Miao
European Journal of Medicinal Chemistry, 2019

8. Discovery, Synthesis, and Biological Evaluation of Orally Active Pyrrolidone Derivatives As Novel Inhibitors of P53-Mdm2 Protein-Protein Interaction.
Chunlin Zhuang; Zhenyuan Miao; Lingjian Zhu; Guoqiang Dong; Zizhao Guo; Shengzheng Wang; Yongqiang Zhang; Yuelin Wu; Jianzhong Yao; Chunquan Sheng; Wannian Zhang
Journal of Medicinal Chemistry, 2012

9. Divergent Cascade Construction of Skeletally Diverse "privileged" Pyrazole-Derived Molecular Architectures
Yongqiang Zhang; Shanchao Wu; Shengzheng Wang; Kun Fang; Guoqiang Dong; Na Liu; Zhenyuan Miao; Jianzhong Yao; Jian Li; Wannian Zhang; Chunquan Sheng; Wei Wang
ChemInform, 2015

10. Three-Dimensional Model of Lanosterol 14 Alpha-Demethylase from Cryptococcus Neoformans: Active-Site Characterization and Insights into Azole Binding
Chunquan Sheng; Zhenyuan Miao; Haitao Ji; Jianzhong Yao; Wenya Wang; Xiaoying Che; Guoqiang Dong; Jiaguo Lue; Wei Guo; Wannian Zhang
Antimicrobial Agents and Chemotherapy, 2009

1. Nicotinic acid or isonicotinic acid compound and use thereof
ACADEMY OF MILITARY MEDICAL SCIENCES
Hui Wang; Tao Li; Zhenyuan Miao; Jianxin Wang; Deyan Luo; Jie Huang; Chunlin Zhuang; Yuelin Wu
公开日期: 2021-04-20 申请日期: 2017-09-08 公开号: US10981873B2

2. NICOTINIC ACID OR ISONICOTINIC ACID COMPOUND AND USE THEREOF
Academy of Military Medical Sciences
Hui WANG; Tao LI; Zhenyuan MIAO; Jianxin WANG; Deyan LUO; Jie HUANG; Chunlin ZHUANG; Yuelin WU
公开日期: 2019-08-08 申请日期: 2017-09-08 公开号: US20190241522A1

3. 含有七元内酰胺环的荜拔酰胺类似物及其制备与应用
UNIV PLA 2ND MILITARY MEDICAL
MIAO ZHENYUAN; ZHANG WANNIAN; WU YUELIN; SHENG CHUNQUAN; ZHUANG CHUNLIN; MIN XIAO; YAO JIANZHONG; DONG GUOQIANG
公开日期: 2019-07-23 申请日期: 2014-08-29 公开号: CN105367495B

4. 紫红素-18醚类衍生物及其制备方法和用途
UNIV PLA 2ND MILITARY MEDICAL
LIU NA; YAO JIANZHONG; MENG ZHI; ZHANG WANNIAN; SHENG CHUNQUAN; MIAO ZHENYUAN; DONG GUOQIANG; JIA NINGYANG; HAN GUIYAN; LIU MINGHUI
公开日期: 2019-02-19 申请日期: 2016-05-25 公开号: CN106083872B

5. Mercaptonicotinic acid compound and preparation method and use thereof
INST OF MICROBIOLOGY AND EPIDEMIOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES PR CHINA; THE SECOND MILITARY MEDICAL UNIV
WANG HUI; ZHNG WANNIAN; MIAO ZHENYUAN; LI TAO; LIU XIONG; WU YUELIN; LUO SEN; SHENG CHUNQUAN; LU XIAOXUE; YAO JIANZHONG
公开日期: 2018-07-31 申请日期: 2014-05-19 公开号: US10035771B2

6. 烟酸或异烟酸类化合物及其用途
INST OF MICROBIOLOGY AND EPIDEMIOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES CHINESE PEOPLE'S LIBERATI
MIAO ZHENYUAN; ZHANG WANNIAN; ZHUANG CHUNLIN; HUANG JIE; WANG HUI; LI TAO; WANG JIANXIN; LU XIAOXUE; WU YUELIN
公开日期: 2018-01-18 申请日期: 2017-09-08 公开号: WO2018010702A1

7. MERCAPTONICOTINIC ACID COMPOUND AND PREPARATION METHOD AND USE THEREOF
INST OF MICROBIOLOGY AND EPIDEMIOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES PR CHINA; UNIV PLA 2ND MILITARY MEDICAL
WANG HUI; ZHNG WANNIAN; MIAO ZHENYUAN; LI TAO; LIU XIONG; WU YUELIN; LUO SEN; SHENG CHUNQUAN; LU XIAOXUE; YAO JIANZHONG
公开日期: 2017-01-04 申请日期: 2014-05-19 公开号: EP3000807A4

8. 二氢卟吩p6类氨基酸衍生物及其制备方法和用途
UNIV PLA 2ND MILITARY MEDICAL
YAO JIANZHONG; MENG ZHI; ZHANG WANNIAN; SHENG CHUNQUAN; MIAO ZHENYUAN; DONG GUOQIANG; JIA NINGYANG; HAN GUIYAN; LIU MINGHUI; LIU NA
公开日期: 2016-10-26 申请日期: 2016-05-25 公开号: CN106046008A

9. MERCAPTONICOTINIC ACID COMPOUND AND PREPARATION METHOD AND USE THEREOF
INST OF MICROBIOLOGY AND EPIDEMIOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES PR CHINA; UNIV PLA 2ND MILITARY MEDICAL
WANG HUI; ZHNG WANNIAN; MIAO ZHENYUAN; LI TAO; LIU XIONG; WU YUELIN; LUO SEN; SHENG CHUNQUAN; LU XIAOXUE; YAO JIANZHONG
公开日期: 2016-03-24 申请日期: 2014-05-19 公开号: US2016083347A1

10. MERCAPTONICOTINIC ACID COMPOUND AND PREPARATION METHOD AND USE THEREOF
INST OF MICROBIOLOGY AND EPIDEMIOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES PR CHINA; UNIV PLA 2ND MILITARY MEDICAL
WANG HUI; ZHNG WANNIAN; MIAO ZHENYUAN; LI TAO; LIU XIONG; WU YUELIN; LUO SEN; SHENG CHUNQUAN; LU XIAOXUE; YAO JIANZHONG
公开日期: 2014-11-27 申请日期: 2014-05-19 公开号: WO2014187291A1

11. PYRROLIDONOPYRAZOLE COMPOUNDS AND USE THEREOF AS DRUGS
UNIV PLA 2ND MILITARY MEDICAL
ZHANG WANNIAN; YAO JIANZHONG; ZHUANG CHUNLIN; GUO ZIZHAO; MIAO ZHENYUAN; WU YUELIN; SHENG CHUNQUAN; LI JIN
公开日期: 2014-09-12 申请日期: 2014-03-04 公开号: WO2014134968A1

12. 一种光学纯高喜树碱中间体的制备方法
UNIV PLA 2ND MILITARY MEDICAL
WANNIAN ZHANG; ZHENYUAN MIAO; LINGJIAN ZHU; CHUNQUAN SHENG; JIANZHONG YAO
公开日期: 2014-07-09 申请日期: 2012-06-19 公开号: CN102702214B

13. 高喜树碱类化合物及其作为药物的用途
UNIV PLA 2ND MILITARY MEDICAL
WANNIAN ZHANG; WENFENG LIU; ZHENYUAN MIAO; LINGJIAN ZHU; CHUNQUAN SHENG; JIANZHONG YAO; WEI GUO; PENGFEI CHENG; CHUNLIN ZHUANG
公开日期: 2012-10-17 申请日期: 2010-12-09 公开号: CN102010418B

14. High-camptothecin compounds and use thereof as medicaments
UNIV PLA 2ND MILITARY MEDICAL
WANNIAN ZHANG; WENFENG LIU; ZHENYUAN MIAO; LINGJIAN ZHU; CHUNQUAN SHENG; JIANZHONG YAO; WEI GUO; PENGFEI CHENG; CHUNLIN ZHUANG
公开日期: 2011-04-13 申请日期: 2010-12-09 公开号: CN102010418A

15. Intelligent packer with manipulator for receiving and sending swabs and quantificationally dosing and use method thereof
JIANGSU PROVINCE JIANERKANG MEDICAL DRESSING CO LTD
XIAOJIAN CHU; WANNIAN ZHANG; LUOJUN CHEN; JIANZHONG SUN; HOUQUAN GAN; GUOPING CHEN; ZHENYUAN MIAO
公开日期: 2010-09-08 申请日期: 2010-04-19 公开号: CN101823569A

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