天然气化工,新材料,石油炼制,石油化工,精细化工,生物医药

1，用于制备生物活性分子与有机功能材料的有机化学新反应的研究与开发
2，活性天然产物全合成、结构修饰及生物活性研究
3，新型载药材料的研究与开发

教学改革;二聚反应;专业英语;复合型人才;新工科;噁唑;C5位官能团化;生物工程;糖皮质激素;丙酸氟替卡松

Thiazole;Oxazole;Palladium-catalyzed;Catalysis;C-h Bond Activation;Antitumor;Total Synthesis;Alkenylation;Homogeneous And Heterogeneous Catalysis;Synthesis

[1] Chen, Jiaming; Wang, Fang; Huang, Yanping; Jia, Xiaoqi; Zhuang, Dailin; Wan, Zhenyang; Li, Ziyuan.* Remote carbamate-directed site-selective benzylic C–H oxygenation via synergistic copper/TEMPO catalysis at room temperature. Org. Chem. Front., 2022, 9, 3169-3178. (中科院I区)
[2] Wang, Fang; Chen, Jiaming; Jia, Xiaoqi; Zhuang, Dailin; Wan, Zhenyang; Ma, Lifang; Li, Ziyuan.* Direct Benzylic C(sp3)−O Coupling with Alcohol via Site-Selective C(sp3)−H Cleavage at Room Temperature through a Remote Directing Group-Enabled Radical Relay Strategy. J. Org. Chem., 2022, 87, 10698-10709. (中科院II区)
[3] Yang, Dong;§ Chen, Jiaming;§ Huang, Yanping; Pan, Huiquan; Shi, Jingqi; Zhang, Yingyue; Wang, Fang; Li, Ziyuan.* Room-temperature Formal Aza-Wacker Cyclization through Synergistic Copper/TEMPO-catalyzed Radical Relay. ACS Catal., 2021, 11, 9860-9868. (中科院I区)
[4] Shao, Zhong; Wang, Fang; Shi, Jingqi; Ma, Lifang; Li, Ziyuan.* Synergetic copper/TEMPO-catalysed benzylic C–H imidation with N-fluorobenzenesulfonimide at room temperature and tandem conversions with alcohols or arenes. Org. Chem. Front., 2021, 8, 3298-3307. (中科院I区)
[5] Miao, Qi; Shao, Zhong; Shi, Cuiying; Ma, Lifang; Wang, Fang; Fu, Ruoqi; Gao, Haochen; Li, Ziyuan.* Metal-free C-H amination of arene with N-fluorobenzenesulfonimide catalysed by nitroxyl radicals at room temperature. Chem. Commun., 2019, 55, 7331-7334. (中科院I区)
[6] Wu, Chuanhai; Tu, Yan-Bei; Li, Ziyuan;* Li, Yanfang.* Highly selective carbamate-based butyrylcholinesterase inhibitors derived from a naturally occurring pyranoisoflavone. Bioorg. Chem., 2019, 88, 102949. (中科院II区)
[7] Wang, Xiaojiao; Lei, Bowen; Ma, Lifang; Jiao, Huixuan; Xing, Wenhua; Chen, Jiaming; Li, Ziyuan*. Iron-catalyzed C(5)-H Imidation of Azole with N-Fluorobenzenesulfonimide. Adv. Synth. Catal., 2017, 359, 4284-4288. (中科院II区)
[8] Ziyuan Li, Xiaoqiang Huang, Feng Chen, Chun Zhang, Xiaoyang Wang, Ning Jiao*. Cu-Catalyzed Concise Synthesis of Pyridines and 2-(1H)-Pyridones from Acetaldehydes and Simple Nitrogen Donors. Org. Lett. 2015, 17, 584-587. (中科院I区)
[9] Ziyuan Li, Ling Ma, Lingyi Kong, Jinyi Xu, Xiaoming Wu, Hequan Yao*. Pd(II)-catalyzed Direct C5-arylation of Azole-4-carboxylates through Double C–H Bond Cleavage. Chem. Commun. 2012, 48, 3763-3765. (中科院I区)
[10] Lei Zhao, Ziyuan Li, Lin Chang, Lingyi Kong, Hequan Yao*, Xiaoming Wu*. Efficient Construction of Fused Indolines with a 2-Quaternary Center via an Intramolecular Heck Reaction with a Low Catalyst Loading. Org. Lett. 2012, 14, 2066-2069. (中科院I区)

1. 一种噻唑-4-甲酸乙酯类衍生物的制备方法
中国药科大学
姚和权; 徐进宜; 王宜运; 李子元; 黄玥; 吴晓明
公开日期: 2011-09-07 申请日期: 2011-03-17 公开号: CN102174028A

1，基于烯烃氮化反应的杂环合成新方法及其关键科学问题探索，国家自然科学基金，主持。
2，基于流动化学技术的复杂天然产物关键片段C-H官能团化工具箱与衍生物库的构建及其生物活性研究，四川省科技厅重点研发项目，主持。
3，四川大学“化工之星”青年人才培育项目，主持。
4，五元含氮杂环官能团化新方法及其在活性天然产物结构修饰与优化中的应用，四川大学青年教师科研启动基金，主持。
5，新型黄酮类丁酰胆碱酯酶抑制剂的结构修饰和作用机制研究，四川省科技厅重点研发项目，主研。
6，四种荚膜多糖纯化工艺改进，企业技术开发项目，主研。
7，甜叶菊糖苷分离精制技术开发研究，企业技术开发项目，主研。

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