精细化工

不对称催化和金属卡宾化学

Enantioselective Construction of Quaternary Stereocenters via A Chiral Spiro Phosphoric Acid Assisted Formal Gold Carbene gem-Dialkylation Reaction. Kewei Chen, Su Zhou, Chao Li, Shanliang Dong, Kemiao Hong, and Xinfang Xu*, J. Am. Chem. Soc. 2024, 146, 19261–19270.
Catalytic [4+2]- and [4+4]-cycloaddition using furan-fused cyclobutanone as a privileged C4 synthon. Kemiao Hong, Mengting Liu, Lixin Qian, Ming Bao, Gang Chen, Xinyu Jiang, Jingjing Huang, and Xinfang Xu*, Nat. Commun. 2024, 15, 5407.
Catalytic (4+2) Annulation via Regio- and Enantioselective Interception of in-situ Generated Alkylgold Intermediate. Ming Bao, Yi Zhou, Haoxuan Yuan, Guizhi Dong, Chao Li, Xiongda Xie, Kewei Chen, Kemiao Hong, Zhi-Xiang Yu*, and Xinfang Xu*, Angew. Chem. Int. Ed. 2024, 63, e202401557.
Catalytic Asymmetric Difluoroalkylation Using In Situ Generated Difluoroenol Species as the Privileged Synthon. Xiongda Xie, Shanliang Dong, Kemiao Hong, Jingjing Huang, and Xinfang Xu*, Adv. Sci. 2024, 11, 2307520.
Catalytic 4-exo-dig carbocyclization for the construction of furan-fused cyclobutanones and synthetic applications. Kemiao Hong, Yi Zhou, Haoxuan Yuan, Zhijing Zhang, Jingjing Huang, Shanliang Dong, Wenhao Hu, Zhi-Xiang Yu*, and Xinfang Xu*, Nat. Commun. 2023, 14, 6378.
Construction of Chiral Quaternary Carbon Centers via Asymmetric Metal Carbene gem-Dialkylation. Shanliang Dong, Kemiao Hong, Zhijing Zhang, Jingjing Huang, Xiongda Xie, Haoxuan Yuan, Wenhao Hu, and XinfangXu*, Angew. Chem. Int. Ed. 2023, 62, e202302371
Ming Bao, Su Zhou, Wenhao Hu, and Xinfang Xu,* Recent advances in gold-complex and chiral organocatalyst cooperative catalysis for asymmetric alkyne functionalization. Chinese Chem. Lett. 2022, 33, 4969–4979.
Su Zhou, Yinwu Li, Xiangrong Liu, Wenhao Hu,* Zhuofeng Ke,* and Xinfang Xu,* Enantioselective Oxidative Multi-Functionalization of Terminal Alkynes with Nitrones and Alcohols for Expeditious Assembly of Chiral α‑Alkoxy-β-amino-ketones. J. Am. Chem. Soc. 2021, 143, 14703-14711.
Cheng Zhang, Kemiao Hong, Chao Pei, Su Zhou, Wenhao Hu, A. Stephen K. Hashmi*, and Xinfang Xu*, Gold(I)-Catalyzed Intramolecular Cyclization/ Intermolecular Cycloaddition Cascade as a Fast Track to Polycarbocycles and Mechanistic Insights. Nat. Commun. 2021, 12, 1182.
(2) Multi-Component Reaction via gem -Difunctionalization of Metal Carbene, Mengchu Zhang, Xinfang Xu, Wenhao Hu, In Transition Metal‐Catalyzed Carbene Transformations. Editors, Jianbo Wang, Chi-Ming Che, Michael P. Doyle, Wiley‐VCH GmbH, 2022, chapter 11. (Print ISBN:9783527347995, Online ISBN:9783527829170) https://doi.org/10.1002/9783527829170.ch11
(3) Synthesis of N-Heterocycles via [3 + n] Cycloaddition Reactions of Vinyl Metal Carbene Intermediates, Ming Bao, Su Zhou, Xinfang Xu, In More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles 2V Set, First Edition. Edited by Ana Maria Faisca Phillips. 2022, John Wiley & Sons Ltd. chapter 5. (Print ISBN: 978-1-119-75712-2)
(4) Catalytic Aromatic C-H Functionalization Involving Metal Carbene, Ming Bao, Jingjing Huang, Xinfang Xu, In Handbook of CH-Functionalization. First Edition. Edited by Debabrata Maiti. 2023 WILEY-VCH GmbH (DOI: 10.1002/9783527834242.chf0174). https://onlinelibrary.wiley.com/doi/10.1002/9783527834242.chf0174
(5) Heterocycles from Cascade Reactions via Carbene gem-Difunctionalization, Mengchu Zhang, Xinfang Xu, Wenhao Hu, In Topics in Heterocyclic Chemistry.  Edited by Michael P. Doyle, Xinfang Xu, 2023 Springer (https://doi.org/10.1007/7081_2022_58)
(6) α,b-Bifunctionalized Carbonyl Compounds as Privileged Motifs in Drug Discovery and Their Synthetic Protocols, Weichen Xiong, Wenhao Hu, Xinfang Xu, In Privileged Scaffolds in Drug Discovery. Edited by Bin Yu, Ning Li, Caiyun Fu, 2023 ELSEVIER Chapter 22 (ISBN: 9780443186110)
(7) Heterocycles from Carbenes and Nitrenes. In: Topics in Heterocyclic Chemistry. Edited by Michael P. Doyle, Xinfang Xu, 2023 Springer, Berlin, Heidelberg (ISSN 1861-9282)

国家自然科学基金青年科学基金项目：金属卡宾串联反应高效构建多环类化合物的研究（项目号：21602148），20万，2017-2019，主持。
江苏省自然科学青年基金：乙烯基金属卡宾参与的环状化合物高效合成反应研究（项目号BK20150315），20万，2015-2018，主持。
国家自然科学基金面上项目：基于金属卡宾中间体过程的炔烃官能团化新反应研究（项目号：21971262），65万，2020-2023，主持。
国家自然科学基金面上项目：手性硫叶立德中间体过程的卡宾不对称催化反应研究（项目号：22371309），50万，2024-2027，主持。
广东省基础与应用基础研究基金自然科学基金面上项目：以肽脱甲酰基酶（PDF）为靶点的新型抗阴性菌小分子抑制剂的设计，合成及活性评价（项目号：2021A1515010384），10万，2021-2023，主持。Guangdong Basic and Applied Basic Research
新疆特色药食用植物资源化学实验室开放课题：一枝蒿酮酸衍生物的立体选择性合成及其活性研究（项目号：KSUZDSYS202103），5万，2022-2024，主持。
广东省重点领域研发计划项目：重大手性药物的化学-生物催化偶联绿色合成技术及产业化研究（项目号：21202107201900002），200万元（项目总经费1000万元），2022年1月-2025年1月，子课题负责人。