精细化工

（1）药物化学（抗HIV病毒、冠状病毒小分子药物）
Medicinal chemistry of anti-HIV and anti-coronavirus agents ;
（2）手性化学（手性分子荧光识别与分析、不对称合成与催化）
Chiral chemistry (Fluorescent recognition and analysis of chiral molecules, Asymmetric synthesis & catalysis)
（3）药物合成工艺 & 绿色化工过程
Synthetic process of pharmaceuticals, Green chemical process

Nnrtis;Diarylpyrimidines;Fluorescent Probe;AIDS;Hiv-1;Enantioselectivity;HIV;SAR;Reverse Transcriptase;Pharmacophore

主持国家自然科学基金（3项）、武汉市国际科技合作项目、湖北省自然科学基金面上项目、湖北省自然科学基金青年基金、湖北省教育厅科学研究计划项目、湖北省高等学校青年教师深入企业行动计划项目、新农药创制与开发国家重点实验室开放基金等项目多项，主持多项企业委托的新药发现和原料药合成工艺开发项目。

以第一作者或通讯作者在Journal of the American Chemical Society、Chinese Chemical Letters、European Journal of Medicinal Chemistry、Bioorganic Chemistry、Organic Letters、Chinese Journal of Chemistry、Current Opinion in Pharmacology、Chemistry – A European Journal、Organic Process Research & Development、《药学学报》、《中国新药杂志》、《中国医药工业杂志》等期刊发表论文80余篇，其中多篇论文入选ESI高被引论文、封面论文、热点论文以及被ChemistryViews等亮点报道；受邀撰写多篇中、英文综述，组稿多期专刊（Special issue）；多次受邀在国际和国内学术会议作学术报告；获得16件中国发明专利授权和1项湖北省科技成果登记证书，多件专利实现转让；担任Journal of Medicinal Chemistry、Acta Pharmaceutica Sinica B、European Journal of Medicinal Chemistry、Organic Process Research & Development、Chemical Communications、Chinese Chemical Letters、《药学学报》、《中国医药工业杂志》等40余SCI期刊和中文核心期刊审稿人，多次获得优秀组稿奖、优秀编委、优秀审稿人荣誉证书；2019年度获湖北省化学化工青年创新奖，2020年度获湖北省化学化工青年科学家论坛“青年报告最佳奖”，2021年获得2021 International Symposium of Frontier Sciences On New Drug Discovery优秀报告奖二等奖。2023年和2024年两度获得湖北省科协优秀科技论文荣誉，2024年获得武汉工程大学“科研十佳”和全国药物化学研究与药物合成新进展研讨会优秀报告奖等荣誉称号。

[1] Chen, Jiong; Zhu, Yuan-Yuan; Huang, Lu; Zhang, Shuang-Shuang*; Gu, Shuang-Xi*. Application of deuterium in research and development of drugs. European Journal of Medicinal Chemistry 2025, 287, 117371.
[2] Zhang, Yi-Xin; Zhang, Fang-Qi; Peng, Ao-Pei; Jiang, Tao; Meng, Ya-Xi; Li, Yang*; Gu, Shuang-Xi*; Zhu, Yuan-Yuan*. Enantioselective recognition of amino acids in water using emission-tunable chiral fluorescent probes. Chinese Chemical Letters 2025, 111500.
[3] Jia, Feng-Cheng*; Luo, Lei-Xiao; Chen, Yao-Hui; Xiang, Qian; Hu, Xiao-Qiang*; Gu, Shuang-Xi*. Strain-release driven α,β-difunctionalization of cyclopropanols with bromonaphthols. Organic Chemistry Frontiers 2025, 12, 3469-3474.
[4] Liu, Bai-Xue; Feng, Fan; Long, Jiao*; Gu, Shuang-Xi*. Recent Advances in Transition Metal-Catalyzed Asymmetric Synthesis of P-chiral Organophosphorus Compounds (2020–Present). Chinese Journal of Chemistry 2025, 43, 2228-2244.
[5] Xia, Meng; Li, Ziteng; Jiang, Hanrui; Li, Yuanqing; Hu, Linghao; He, Yongchang; Huang, Siqi; Tang, Lei; Luo, Cheng; Gu, Shuangxi*; Ding, Hong*; Wang, Mingliang*. Discovery of novel imidazo[1,2-b]pyridazine derivatives as potent covalent inhibitors of CDK12/13. European Journal of Medicinal Chemistry 2025, 288, 117378.
[6] Peng, Ao-Pei; Liang, Yu-Li; Wu, Guang-Wen; Zeng, Jie; Li, Yang*; Gu, Shuang-Xi*; Zhu, Yuan-Yuan*. Efficient synergistic recognition of D/L-cysteine and zinc ions using a chiral chemosensor. Sensors and Actuators B: Chemical 2025, 442, 138062.
[7] Fu, Shi-Wei; Huang, Zong-Xing; Ni, Chuan-Zhi; Zhang, Fang-Qi; Li, Yang; Zhu, Yuan-Yuan*; Sun, Qi*; Gu, Shuang-Xi*. A fluorescent probe for enantioselective recognition of amino acids in solutions, cells and zebrafishes. Dyes and Pigments 2025, 239, 112739.
[8] Zhang, Fang-Qi; Xu, Zhi-Yong; Li, Yang; Zhu, Yuan-Yuan*; Gu, Shuang-Xi*. Chemoselective and enantioselective fluorescent recognition of basic amino acids: A review. Dyes and Pigments 2025, 240, 112842.
[9] Zhang, Xiaorui; Zhao, Jie; Yang, Qichang; Chen, Zhangxuan; Wang, Haifeng; Gu, Shuang-Xi; Lv, Jian*. Trimethylsulfoxonium iodide: a green methylating agent for site-selective methylation of carbohydrates. Green Chemistry 2025, 27, 1652-1657.
[10] 彭澳霈, 李扬, 朱园园*, 吴广文*, 古双喜*. 希弗碱型荧光探针对氨基酸化学选择性识别研究进展. 有机化学 2025, DOI: 10.6023/cjoc202503015.
[11] Nie, Mu-Zi; Zhang, Shuang-Shuang; Gu, Shuang-Xi*; Long, Jiao*; Zhu, Yuan-Yuan*. Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors (2019-2023). European Journal of Medicinal Chemistry 2024, 280, 116973.
[12] Ni, Chuan-Zhi; Li, Ruo-Ming; Zhang, Fang-Qi; Li, Qu-Ao-Wei; Zhu, Yuan-Yuan*; Zeng, Jie*; Gu, Shuang-Xi*. A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells. Chinese Chemical Letters 2024, 35, 109862.
[13] Li, Huan; Xia, Zhimin; Li, Lewan; Zeng, Jie; Lv, Jian; Wang, Haifeng*; Gu, Shuangxi*; Chen, Fener*. Regioselective Cleavage and Reconfiguration of C-S Bonds with Diazo Compounds. Organic Letters 2024, 26, 8405-8409.
[14] Jia, Feng-Cheng; Yuan, Zi-Yi; Luo, Na; Gu, Shuang-Xi; Hu, Xiao-Qiang. Modular Assembly of Six-Membered Carbocyclic Spirooxindoles via Peterson Olefination/Michael Addition/C(sp3) Arylation Cascade. Chinese Journal of Chemistry 2024, 42, 2614-2620.
[15] Xiao, Ya-Qi; Long, Jiao; Zhang, Shuang-Shuang*; Zhu, Yuan Yuan*; Gu, Shuang-Xi*. Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review. Bioorganic Chemistry 2024, 147, 107380.
[16] Peng, Jin-Qi; Xiao, Ya-Qi; Long, Jiao; Zhang, Shuang-Shuang*; Zhu, Yuan-Yuan*; Gu, Shuang-Xi*. Design, synthesis, and biological evaluation of dithiocarbamate derivatives as SARS-CoV-2 M pro inhibitors. Bioorganic & Medicinal Chemistry Letters 2024, 114, 130011.
[17] Zhou, Shuqi; Li, Chunyan; Zeng, Jie; Lv, Jian; Liao, Jie; Wang, Haifeng*; Yan, Qiongjiao*; Gu, Shuangxi*. Al(OTf)3-Catalyzed Regioselective N2-Arylation of Tetrazoles with Diazo Compounds. Journal of Organic Chemistry 2024, 89, 7859-7864.
[18] Zhang, Shuang-Shuang*; Yu, Jia-Hui; Jiang, Si Si; Wang, Lun; Chen, Jiong; Long, Jiao; Gu, Shuang-Xi*; Li, Hui*. T7 peptide-mediated co-delivery platform overcoming multidrug-resistant breast cancer: In vitro and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics 2024, 200, 114327.
[19] Luo, Mengxiang; Li, Lewan; Chen, Shixin; Yan, Qiongjiao; Lv, Jian; Zeng, Jie; Wang, Haifeng*; Gu, Shuangxi*; Chen, Fener*. Synthesis of 2,4-Disubstituted Oxazoles and Thiazoles via Brønsted Acid-Catalyzed Cyclization of α-diazoketones with Amides. Journal of Organic Chemistry 2024, 89, 5038-5048.
[20] Hu, Wen-Xiang; Yu, Kai-Heng; Jia, Feng-Cheng; Gu, Shuang-Xi. Convergent Assembly of 1,4-Benzothiazide Spiroindolinones via 4+2 Spiroannulation Under Open-Air Conditions. Journal of Organic Chemistry 2024, 89, 16531-16541.
[21] Li, Feifan; Yu, Kang; Chuanzhi, Ni; Zhu, Yuanyuan; Zeng, Jie; Gu, Shuangxi. Chiral Fluorescent Probes for Determination of Both Concentration and Enantiomeric Composition of Amino Acids. Chinese Journal of Organic Chemistry 2024, 44, 1862-1869.
[22] Feng, Kangbo; Chen, Jiong; Gu, Shuangxi; Wang, Haifeng; Chen, Fen'er. New Progress of Fully Continuous Flow Reaction Technologies in Pharmaceutical Synthesis (20192022). Chinese Journal of Organic Chemistry 2024, 44, 378-397.
[23] Ming, Wei; Lu, Wen-Long; Pannecouque, Christophe; Chen, Jiong; Wang, Hai-Feng; Xiao, Ya-Qi; Hu, Sha; Gu, Shuang-Xi*; Zhu, Yuan-Yuan*; Chen, Fen-Er.* Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities. European Journal of Medicinal Chemistry, 2023, 248, 115114.
[24] Hu, Sha; Chen, Jiong; Cao, Jin-Xu; Zhang, Shuang-Shuang; Gu, Shuang-Xi*; Chen, Fen-Er*. Quinolines and isoquinolines as HIV-1 inhibitors: Chemical structures, action targets, and biological activities. Bioorganic Chemistry, 2023, 136, 106549.
[25] Li, Chenzong; Xiang, Xun; Zhang, Xianghe; He, Zhao-Lin*; Gu, Shuang-Xi*; Dong, Xiu-Qin*. Iridium-Catalyzed Intramolecular Asymmetric Allylation of Vinyl Benzoxazinones for the Synthesis of Chiral 4H-3,1-Benzoxazines via Kinetic Resolution. Organic Letters, 2023, 25, 1172−1177.
[26] Sun, Meng-Xin; Ni, Chuan-Zhi; Zhang, Fang-Qi; Zhu, Yuan-Yuan*; Zeng, Jie*; Gu, Shuang-Xi*. Chiral amino acid recognition in water: A BINOL-based fluorescent probe. Chinese Chemical Letters, 2023, 34, 108345.
[27] Jiang, Hanrui; Xiong, Huan; Gu, Shuang-Xi*; Wang, Mingliang*. E3 ligase ligand optimization of Clinical PROTACs. Frontiers in Chemistry, 2023, 11, 1098331.
[28] (a) Hong, Yu; Zhu, Yuan-Yuan*; Gu, Shuang-Xi*. Preparation of (S)-3,3ʹ-Bis(1- pyrrolidinylmethyl)-5,5ʹ,6,6ʹ,7,7ʹ,8,8ʹ-octahydro-1,1'-bi-2-naphthol. Organic Syntheses, 2023, 100, 394–403. (b) Chen, Jiong; Zhu, Yuan-Yuan*; Gu, Shuang-Xi*. Preparation of (S)-5,5ʹ,6,6ʹ,7,7ʹ,8,8ʹ- Octahydro-1,1'-bi-2-naphthol [(S)-H8BINOL]. Organic Syntheses, 2023, 100, 404-417.
[29] 李屈澳薇, 龚智华, 陈炯, 张双双, 古双喜*. 泼尼松磷酸酯二钠的合成及其在水中的溶解度测定. 中国药物化学杂志, 2023, 33(7), 529−534.
[30] Ming, Wei; Hu, Sha; Liu, Ye; Li, Qu-Ao-Wei; Zhu, Yuan-Yuan*; Gu, Shuang-Xi*. Recent Advances in the Chemical Synthesis of β-Nicotinamide Mononucleotide. Current Organic Chemistry, 2022, 26, 2151−2159.
[31] 刘烨, 明巍, 朱园园, 古双喜. 临床应用中的新型冠状病毒肺炎治疗药物研究进展. 中国新药杂志, 2022, 31(20), 2022−2028.
[32] Chen, Jiong; Ming, Wei; Fan, De-Hua; Gu, Shuang-Xi*. Synthesis and Characterization of Related Substances of Torasemide. Pharmaceutical Fronts, 2022, 4(3), e157−e161. （Cover feature）
[33] Gong, Zhihua; Hu, Sha; Jin, Xueping; Yu, Lei; Zhu, Yuanyuan; Gu, Shuangxi*. Synthetic Methods and Application of Phosphoester Prodrugs[J]. Progress in Chemistry, 2022, 34(9), 1972−1981
[34] Hong, Yu; Zhu, Yuan-Yuan; He, Qiuqin; Gu, Shuang-Xi*. Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents. Bioorganic & Medicinal Chemistry, 2022, 55, 116597.
[35] Ge, Rui; Zhu, YuanYuan; Wang, Haifeng; Gu, Shuang-Xi. Methods and Application of Absolute Configuration Assignment for Chiral Compounds. Chinese Journal of Organic Chemistry, 2022, 42(2), 424-433.
[36] 刘玉, 明巍, 李陈宗, 朱园园, 古双喜*. 拟肽类冠状病毒主蛋白酶抑制剂的研究进展. 药学学报, 2022, 57, 1977-1990.
[37] Wang, Yue; Gu, Shuang-Xi*; He, Qiuqin*; Fan, Renhua. Advances in the development of HIV integrase strand transfer inhibitors. European Journal of Medicinal Chemistry, 2021, 225, 113787.
[38] Liu, Ding; Zhu, Yuanyuan; Gu, Shuangxi*; Chen Fen-Er*. Application of Flow Chemistry in Halogenation. Chinese Journal of Organic Chemistry,2021, 41, 1002-1011.
[39] Gu, Shuang-Xi*; Zhu, Yuan-Yuan; Wang, Chao; Wang, Hai-Feng; Liu, Gen-Yan; Cao, Shuang; Huang, Lu. Recent discoveries in HIV-1 reverse transcriptase inhibitors. Current Opinion in Pharmacology, 2020, 54, 166-172.
[40] Xiao, Ting#; Tang, Jia-Fan#; Meng, Ge; Pannecouque, Christophe; Zhu, Yuan-Yuan; Liu, Gen-Yan; Xu, Zhi-Qiang; Wu, Feng-Shou; Gu, Shuang-Xi*; Chen, Fen-Er*. Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities. European Journal of Medicinal Chemistry, 2020, 186, 111864.
[41] Wang, Chao; Liu, Xiao-Wen; Xiao, Ting; Xu, Zhi-Qiang; Cao, Shuang; Wang, Hai-Feng; Yan, Qiong-Jiao; Gu, Shuang-Xi*; Zhu, Yuan-Yuan*. Anticancer activity evaluation of indazolyl-substituted piperidin-4-yl-aminopyrimidines. Medicinal Chemistry Research, 2020, 29(5), 910-915.
[42] Wang, Haifeng*; Sun, Xiangli; Hu, Manman; Zhang, Xiaoyi; Xie, Lele; Gu, Shuangxi*. Bromination of α-Diazo Phenylacetate Derivatives Using Cobalt(II) Bromide. Advanced Synthesis & Catalysis, 2020, 362(16), 3347-3351.
[43] Gu, Shuang-Xi; Wang, Hai-Feng; Zhu, Yuan-Yuan; Chen, Fen-Er. Natural Occurrence, Biological Functions, and Analysis of D-Amino Acids. Pharmaceutical Fronts, 2020, 2(2): e79-e87. （Cover feature）
[44] Zhu, Yuan-Yuan; Wu, Xue-Dan; Gu, Shuang-Xi*; Pu, Lin*. Free Amino Acid Recognition: A Bisbinaphthyl-Based Fluorescent Probe with High Enantioselectivity. Journal of the American Chemical Society, 2019, 141(1): 175-181. （ESI Highly cited paper）；https://www.x-mol.com/news/15900
[45] Zhu, Yuan-Yuan; Wu, Xue-Dan; Abed, Mehdi; Gu, Shuang-Xi*; Pu, Lin*. Biphasic Enantioselective Fluorescent Recognition of Amino Acids by a Fluorophilic Probe. Chemistry – A European Journal, 2019, 25(33): 7866-7873. （Hot paper and cover feature article of Chem. Eur. J., Highlighted by ChemistryViews）；https://www.chemistryviews.org/details/news/11157496/Enantioselective_Recognition_of_Amino_Acids.html；https://www.x-mol.com/news/18278
[46] Gu, Shuang-Xi*; Xiao, Ting; Zhu, Yuan-Yuan; Liu, Gen-Yan; Chen, Fen-Er*. Recent progress in HIV-1 inhibitors targeting the entrance channel of HIV-1 non-nucleoside reverse transcriptase inhibitor binding pocket. European Journal of Medicinal Chemistry, 2019, 174: 277-291.
[47] Gu, Shuang-Xi*; Lu, Huan-Huan; Liu, Gen-Yan; Ju, Xiu-Lian; Zhu, Yuan-Yuan*. Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors. European Journal of Medicinal Chemistry, 2018, 158: 371-392.
[48] Liu, Genyan*; Wan, Youlan; Wang, Wenjie; Fang, Sai; Gu, Shuangxi*; Ju, Xiulian. Docking-based 3D-QSAR and pharmacophore studies on diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Molecular Diversity, 2019, 23: 107-121.
[49] Liu, Genyan*; Wang, Wenjie; Wan, Youlan; Ju, Xiulian; Gu, Shuangxi*. Application of 3D-QSAR, Pharmacophore, and Molecular Docking in the Molecular Design of Diarylpyrimidine Derivatives as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors. International Journal of Molecular Sciences, 2018, 19(5): 1436.
[50] Lu, Huan-Huan; Xue, Ping; Zhu, Yuan-Yuan*; Ju, Xiu-Lian; Zheng, Xiao-Jiao; Zhang, Xun; Xiao, Ting; Pannecouque, Christophe*; Li, Ting-Ting; Gu, Shuang-Xi*. Structural modifications of diarylpyrimidines (DAPYs) as HIV-1 NNRTIs: Synthesis, anti-HIV activities and SAR. Bioorganic & Medicinal Chemistry, 2017, 25(8): 2491-2497.
[51] Xue, Ping; Lu, Huan-Huan; Zhu, Yuan-Yuan*; Ju, Xiu-Lian; Pannecouque, Christophe; Zheng, Xiao-Jiao; Liu, Gen-Yan; Zhang, Xiu-Lan; Gu, Shuang-Xi*. Design and synthesis of hybrids of diarylpyrimidines and diketo acids as HIV-1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 2017, 27(8): 1640-1643.
[52] Gu, Shuang-Xi*; Xue, Ping; Ju, Xiu-Lian; Zhu, Yuan-Yuan*. Advances in rationally designed dual inhibitors of HIV-1 reverse transcriptase and integrase. Bioorganic & Medicinal Chemistry, 2016, 24(21): 5007-5016.
[53] Gu, Shuang-Xi*; Qiao, Heng; Zhu, Yuan-Yuan; Shu, Qi-Chao; Liu, Hui; Ju, Xiu-Lian*; De Clercq, Erik; Balzarini, Jan; Pannecouque, Christophe. A novel family of diarylpyrimidines (DAPYs) featuring a diatomic linker: Design, synthesis and anti-HIV activities. Bioorganic & Medicinal Chemistry, 2015, 23(20): 6587-6593.
[54] Gu, Shuang-Xi*; Zhu, Yuan-Yuan; Chen, Fen-Er*; De Clercq, Erik; Balzarini, Jan; Pannecouque, Christophe. Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors. Medicinal Chemistry Research, 2015, 24(1): 220-225.
[55] Gu, Shuang-Xi; Huang, Wen-Cai; Wu, Xue-Dan; Ying, Jun; Pu, Lin*. Simple and Efficient One-Step Synthesis of a Highly Enantioselective Catalyst 3,3′-Di(pyrrolidinylmethyl)- H8BINOL. Synthetic Communications, 2015, 45(13): 1541-1545.
[56] Gu, Shuang-Xi; Du, Jia-Wen; Ju, Xiu-Lian*; Chen, Qing-Ping. A Scalable One-Pot Process for the Synthesis of Florfenicol Phosphodiester. Organic Process Research & Development, 2014, 18(4): 552-554.
[57] Gu, Shuang-Xi; Li, Zhi-Ming; Ma, Xiao-Dong.; Yang, Shi-Qiong; He, Qiu-Qin*; Chen, Fen-Er*; De Clercq, Erik; Balzarini, Jan; Pannecouque, Christophe. Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors. European Journal of Medicinal Chemistry, 2012, 53: 229-234.
[58] Gu, Shuang-Xi; Yang, Shi-Qiong; He, Qiu-Qin; Ma, Xiao-Dong; Chen, Fen-Er*; Dai, Hui-Fang*; Clercq, Erik De; Balzarini, Jan; Pannecouque, Christophe. Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs. Bioorganic & Medicinal Chemistry, 2011, 19(23): 7093-7099.
[59] Gu, Shuang-Xi.; He, Qiu-Qin; Yang, Shi-Qiong; Ma, Xiao-Dong; Chen, Fen-Er*; De Clercq, Eric; Balzarini, Jan; Pannecouque, Christophe. Synthesis and structure-activity relationship of novel diarylpyrimidines with hydroxymethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs. Bioorganic & Medicinal Chemistry, 2011, 19(17): 5117-5124.
[60] Gu, Shuang-Xi; Zhang, Xuan; He, Qiu-Qin; Yang, Liu-Meng; Ma, Xiao-Dong; Zheng, Yong-Tang; Yang, Shi-Qiong; Chen, Fen-Er*. Synthesis and biological evaluation of naphthyl phenyl ethers (NPEs) as novel nonnucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry, 2011, 19(14): 4220-4226.

ZL202210261337.2，吲哚哌啶嘧啶类衍生物在制备新型冠状病毒抑制剂中的应用；
ZL202210247140.3，吲哚哌啶嘧啶类衍生物及其制备方法和用途；
ZL202210802669.7，一种雌二醇磷酸酯及其盐的制备方法和应用；
ZL202210802691.1，一种泼尼松磷酸酯及其盐的制备方法和应用；
ZL202210802483.1，一种雌酮磷酸酯及其盐的制备方法和应用；
ZL202210671057.9，一种含有全氟烷基的手性荧光探针及其制备方法和应用；
ZL202210665107.2，一种具有苯并噻唑基团的手性荧光探针及其制备和应用；
ZL201910698458.1，一种吲唑哌啶嘧啶类衍生物及其制备方法和用途；
ZL201910811980.6，一种吲唑哌啶嘧啶类化合物的应用；
ZL201710108100.X，二芳基嘧啶‑二酮酸类杂合型HIV‑1抑制剂及其制备方法；
ZL201510516039.3，一种二芳基嘧啶类HIV‑1抑制剂及其制备方法；
ZL201410798040.5，5-(4-硝基苯基)-3-羟基异噁唑及其制备工艺和用途；
ZL201310136496.0，氟苯尼考磷酸二酯及盐及其制备方法；
ZL201310697748.7，托曲珠利碱金属盐及其制备方法和用途。

1. HIV-1逆转录酶/整合酶双重抑制剂DKA-DAPYs的分子设计、合成及抗HIV活性研究
立项时间: 2015-2017 项目经费：250000

2. 结构生物学导向的非核苷类HIV-1逆转录酶抑制剂设计、合成与生物活性研究
立项时间: 2023

3. 嘧啶类杂合型SARS-COV-2抑制剂的分子设计与合成
立项时间: 2022

4. 嘧啶类HIV-1逆转录酶抑制剂的设计、合成与生物活性研究
立项时间: 2019-2022

技术咨询