精细化工

1) 基于药用植物/微生物资源的新颖活性小分子挖掘
2) 活性天然产物分子的生物合成、酶学催化机制

Atherosclerosis;T1DM;Pleiotropism;IFN-γ;Skin Transplantation;NOD Mice;RS;IgG2a;Adhesion;Mice

Hiapp;Solvent Effect;Phospholipid Membrane;Fibrillogenesis;Inhibitor;Shale Gas;Design For Manufacture;Diabetes;Pharmacological Effects;Cell Signaling

Li Wang, Zijun Xiong, Peng Lai, Jianying Luo, Xin He, Yijun Yan, and Sheng-Xiong Huang*, Natural Trichothecene Mycotoxins from a Rotten Moldy Apple Core-Derived Trichothecium roseum: Occurrence, Identification, and Potential Transfer to Commercial Apple Juice, ACS Food Sci. Technol. 2024, 4(1), 118−125.
Li Wang#, Zhi Zhou#, Jian-Ping Huang, Liang Zhang, Xiaotao Tuo, Zhiyin Yu, Sheng-Xiong Huang, Yang Liu* and Jing Yang*, Strepyrrolins A–E, five pyrrole–sesquiterpene hybrids from Streptomyces sp. KIB 015, revealing a new formation logic of pyrroles by isotope labeling, Org. Chem. Front. 2023, 10(4), 880−889.
Xin He, Guoqing Peng, Jianying Luo, Jian-Ping Huang, Jing Yang, Yijun Yan, Yu-Cheng Gu, Li Wang*, and Sheng-Xiong Huang*, O‑Alkylazoxymycins A−F, Naturally Occurring Azoxy-Aromatic Compounds from Streptomyces sp. Py50, J. Nat. Prod. 2023, 86(1), 176−181.
Jun Tang#, Xueshuang Huang#, Ming-Hang Cao, Zhiyan Wang, Zhiyin Yu, Yijun Yan, Jian-Ping Huang, Li Wang* and Sheng-Xiong Huang*, Mono-/Bis-Alkenoic Acid Derivatives From an Endophytic Fungus Scopulariopsis candelabrum and Their Antifungal Activity, Front. Chem. 2022, 9, 812564.
Li Wang#, Zhiyin Yu#, Xiaowei Guo, Jian-Ping Huang, Yijun Yan, Sheng-Xiong Huang*, and Jing Yang*, Bisaspochalasins D and E: Two Heterocycle-Fused Cytochalasan Homodimers from an Endophytic Aspergillus flavipes, J. Org. Chem. 2021, 86(16), 11198−11205.
Li Wang#, Jing Yang#, Jian-Ping Huang#, Jie Li, Jianying Luo, Yijun Yan, and Sheng-Xiong Huang*, Bisaspochalasins A−C: Three Cytochalasan Homodimers with Highly Fused Ring System from an Endophytic Aspergillus flavipes, Org. Lett. 2020, 22(20), 7930−7935.
Yijun Yan#, Jing Yang#, Li Wang#, Dongdong Xu, Zhiyin Yu, Xiaowei Guo, Geoff P. Horsman, Shuangjun Lin, Meifeng Tao and Sheng-Xiong Huang*, biosynthetic access to the rare antiarose sugar via an unusual reductase-epimerase, Chem. Sci. 2020, 11(15), 3959−3964.
Jie Yuan#, Li Wang#, Jinqiu Ren#, Jian-Ping Huang, Mingming Yu, Jun Tang, Yijun Yan, Jing Yang*, and Sheng-Xiong Huang*, Antibacterial Pentacyclic Polyketides from a Soil-Derived Streptomyces, J. Nat. Prod. 2020, 83(6), 1919−1924.
WANG Yong-Jiang#, WANG Li#, HE Xin#, XU Dong-Dong, TANG Jun, MA Ya-Tuan, YAN Yi-Jun, GU Yu-Cheng, YANG Jing*, HUANG Sheng-Xiong*, Characterization of inthomycin biosynthetic gene cluster revealing new insights into carboxamide formation, Chin. J. Nat. Med. 2020, 18(9), 677−683.
WANG Lei#, WANG Li#, ZHOU Zhi#, WANG Yong-Jiang, HUANG Jian-Ping, MA Ya-Tuan, LIU Yang, HUANG Sheng-Xiong*, Cangumycins A−F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces, Chin. J. Nat. Med. 2019, 17(12), 982−987.
Li Wang#, Jing Yang#, Ling-Mei Kong, Jun Deng, Zijun Xiong, Jianping Huang, Jianying Luo, Yijun Yan, Yikao Hu, Xiao-Nian Li, Yan Li, Yong Zhao*, and Sheng-Xiong Huang*, Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor, Org. Lett. 2017, 19 (14), 3911−3914.

1. 国家自然科学基金面上项目，2025.01– 2028.12，主持，在研；
2. 云南大学“东陆青年学者”引进人才启动项目，2024/09-2030/08，主持，在研；
3. 国家自然科学基金青年项目，2023/01-2025/12，主持，在研；
4. 中国博士后科学基金面上项目，2022/07-2024/03，主持，已结题；
5. 云南省基础研究计划青年项目，2021/04-2024/03，主持，已结题。