精细化工

(1) 氮杂环卡宾催化不对称反应研究；(2) 可见光介导有机催化卡宾转移反应研究。

1. Hua Zhang, Zheyuan Wang, Zirui Wang, Yunpeng Chu, Shuncheng Wang and Xin-Ping Hui*. Visible-light-mediated formal carbene insertion reaction: enantioselective synthesis of 1,4-dicarbonyl compounds containing allcarbon quaternary stereocenter. ACS Catal. 2022, 12, 5510–5516.
2. Yunpeng Chu, Meng Wu, Fang Hu, Panpan Zhou, Zhengqiang Cao and Xin-Ping Hui*. N-Heterocyclic carbene-catalyzed atroposelective synthesis of pyrrolo[3,4-b]pyridine derivatives with configurationally stable C–N axial chirality. Org. Lett. 2022, 24, 3884–3889.
3. Fang Hu, Yunpeng Chu, Zhengqiang Cao, Yucheng Li, and Xin-Ping Hui*. Enantioselective synthesis of functionalized tetrahydropyridines through iridium-catalyzed formal [5+1] annulation. Org. Lett. 2022, 24, 6945–6950.
4. Yunpeng Chu, Fang Hu, Peng Feng and Xin-Ping Hui*. N-Heterocyclic carbene-catalyzed enantioselective dearomatizing annulation of benzoxazoles with enals. Org. Chem. Front. 2022, 9, 1556– 1560.
5. Chengyuan Wang, Zheyuan Wang, Jin Yang, Shi-Hui Shi and Xin-Ping Hui*. Sequential visible-light and N-heterocyclic carbene catalysis: stereoselective synthesis of tetrahydropyrano-[2,3-b]indoles, Org. Lett. 2020, 22, 4440–4443.
6. Chengyuan Wang, Zhuopeng Li, Jiong Zhang and Xin-Ping Hui*. Asymmetric N-alkylation of indoles with isatins catalyzed by N-heterocyclic carbene: efficientsynthesis of functionalizedcyclic N,O-aminal indole derivatives, Org. Chem. Front. 2020, 7, 1647–1652.
7. Shi-Ya Zhu, Yuanzhen Zhang, Xin-Fa Chen, Jun Huang, Shi-Hui Shi and Xin-Ping Hui*. Highly enantioselective synthesis of functionalized azepino[1,2-a]indoles via NHC-catalyzed [3+4] annulation, Chem. Commun. 2019, 55, 4363–4366.
8. Shi-Ya Zhu, Hua Zhang, Qing-Wei Ma, Dou Liu and Xin-Ping Hui*. Oxidative NHC catalysis: direct activation of β sp3carbons of saturated acid chlorides, Chem. Commun. 2019, 55, 298–301.
9. Shi-Ya Zhu, Yuanzhen Zhang, Wei Wang and Xin-Ping Hui*. Stereoselective synthesis of functionalized tetrahydro-1H-1,2-diazepines by N-heterocyclic carbene-catalyzed [3+4] annulation, Org. Lett. 2017, 19, 5380–5383.
10. Yu-Jie Yang, Yuanyuan Ji, Liangliang Qi, Guanjun Wang and Xin-Ping Hui*. Asymmetric synthesis of cyclopenta[3,4]pyrroloindolones via N-heterocyclic carbene-catalyzed Michael/aldol/lactamization cascade reaction, Org. Lett. 2017, 19, 3271–3274.

(1) 可见光介导有机催化不对称卡宾转移反应研究，国家自然科学基金(22271125)，2023.1.–2026.12.
(2) 新手性氮杂环卡宾催化剂的设计、合成及在不对称催化反应中的应用，国家自然科学基金(21971094)，2020.1.–2023.12.
(3) 基于α-溴代-α,β-不饱和醛的N-杂环卡宾不对称催化串联反应研究，国家自然科学基金(21372106)，2014.1.–2017.12.
(4) 唑类并四氢吡啶类化合物的不对称合成、应用和抗肿瘤活性，国家自然科学基金(21172099)，2012.1.–2015.12.
(5) 新型1,3-烯炔手性胺的不对称合成及其金(I)催化的环化反应，国家自然科学基金(20702022)，2008.1.–2010.12.
(6) 具有抗肿瘤活性的新型咪唑/恶唑并四氢吡啶类化合物的不对称合成及活性研究，甘肃省国际科技合作计划项目(1011WCGA170), 2010.7.—2012.6.
(7) 新型双恶/噻唑啉的合成及在不对称Ugi反应中的应用，甘肃省自然科学基金(3ZS051-A25-005)，2006.1.–2007.12.
(8) 具有高效抗高血压作用的新型杂环化合物的合成及应用研究, 甘肃省中青年科技基金(YS-011-A25-001)，2002.1.–2004.12.