精细化工

杂环合成、不对称合成、光催化反应

P. Xie, Y. Zheng, Y. Luo, J. Luo, L. Wu, Zh. Cai,* L. He.*Synthesis of Sulfilimines via Multicomponent Reaction of Arynes, Sulfamides, and Thiosulfonates, Org. Lett. 2023, 25, 6133–6138 (中科院1区, top期刊).
Q. Zhang, L. He,* Q. Liu,* X. Chen,* Charge Transfer Complex-Enabled Synthesis of (Hetero)arylated m-Carboranes from m-Carborane Phosphonium Salts, Org. Lett. 2023, 25, 5768–5773. (中科院1区, top期刊).
Y. Ma, K. Liu, L. He,* H. Lv,* Divergent synthesis of chiral amines via Ni-catalyzed chemo- and enantioselective hydrogenation of alkynone imines, Sci. China Chem. (2023). Doi: 10.1007/s11426-023-1670-8. (中科院1区, top期刊).
Y.-Zh. Ren, C.-Z. Fang, B.-B. Zhang, L. He*, Y.-L. Tu*, X.-Y. Chen*. Photocatalytic Charge-Transfer Complex Enables Hydroarylation of Alkenes for Heterocycle Synthesis, Org. Lett. 2023, 25, 3585-3589 (中科院1区, top期刊).
Sh.-J. Liu, P. Xie, L.-F. Wu, J.-X. Zhao, Zh.-H. Cai,* L. He*, Transition-metal-free synthesis of 4-amino isoquinolin-1(2H)-ones via a tandem reaction of arynes and oxazoles, Org. Chem. Front.,2022, 9, 1550-1555 (中科院1区, top期刊).
Y.-F. Lv, R.-S. Liu, H.-Y. Ding, W. Wei,* X.-H. Zhao,* L. He*. Metal-free visible-light-induced multi-component reactions of α-diazoesters leading to S-alkyl dithiocarbamates, Org. Chem. Front., 2022, 9, 3486-3492 (中科院1区, top期刊).
Sh. Li, Zh. Li, M. Li, L. He, X. Zhang, H. Lv,* A concise access to bridged [2,2,1] bicyclic lactones with a quaternary stereocenter via stereospecific hydroformylation, Nat. Commun. 2021, 12, 5729. (中科院1区, top期刊).
Y. An, F. Zhang, G.-F. Du,* Z.-H. Cai, L. He,* Construction of 6H-benzo[c]thiochromenes via a tandem reaction of arynes with thionoesters, Org. Chem. Front., 2021, 8, 6979-6984 (中科院1区, top期刊).
Y.-F. Lv, J.-Y. Luo, Y.-C. Ma, Q. Dong* and L. He*, Visible-light-promoted sulfonylation of thiols with aryldiazonium and sodium metabisulphite leading to unsymmetrical thiosulfonates, Org. Chem. Front., 2021, 8, 2461-2467(中科院1区, top期刊).
Y.-F. Lv, J.-Y. Luo, M.-Z. Lin, H.-L. Yue* and L. He*, Visible-light photoredox-catalyzed four-component reaction for the construction of sulfone-containing quinoxalin-2(1H)-ones, Org. Chem. Front., 2021, 8, 5403-5409(中科院1区, top期刊).

1. 基于芳炔选择性串联反应直接构筑偕二氟杂环化合物，国家自然科学基金，2022.1-2025.12，主持（在研）
2. 基于芳炔和Baylis-Hillman反应产物的选择性苯并杂环合成，国家自然科学基金，2015.1-2018.12，主持（已结题）
3. 天山英才计划，2023-2025年，主持（在研）