生物医药

利用合成生物技术指导的高值分子微生物合成

1. Guozhen Ma#, Xiaolong Jiang#, Bin Yang#, Linxing Li#, Ruiying Liu, Qing Meng, Jiawei Li, Lijie Xie, Han Guo, Sijia Liu, Yuxuan Wang, Yibo Wang, Xiaojing Zhao , Ziyu Li, Yujie Wang, Menglei Xia, Di Huang*. Development of a High-Efficiency N-acetylneuraminic acid Production Platform through Multi-Pathway Synergistic Engineering. Trends Biotechnol. 2025 Aug 29:S0167-7799(25)00277-X.
2. Yuchen Han, Huayi Gao,* Shuo Wang, Haiyan Ju, Ran Ge, Chaoyou Xue, Weidong Liu, Xiaolong Jiang*, and Wuyuan Zhang*. Pathway Refactoring for Efficient 7-Dehydrocholesterol Production in Saccharomyces cerevisiae. ACS synth. Biol. 2025, 14, 2609−2618.
3. Yu Fu#, Huanhuan Li#, Caihong Xu#, Chengsen Cui, Jiangtao Sha, Junyi Cao, Jie Zhang, Quanshun Li*, Xiaolong Jiang*, Wuyuan Zhang*. Selective Chemoenzymatic Synthesis of Diverse Halo‐Compounds by Vanadium‐Dependent Haloperoxidase. ChemCatChem. 2025, 17, e202500584.
4. Ziyu Li, Yujie Wang, Xiaojing Zhao, Qing Meng, Guozhen Ma, Lijie Xie, Xiaolong Jiang*, Yutao Liu*, Di Huang*. Advances in bacterial glycoprotein engineering: A critical review of current technologies, emerging challenges, and future directions. Biotechnol. Adv, 2025,79: 108514.
5. Xiaolong Jiang#, Liyan Tian#, Wujiu Chen, Qinhong Wang*. High-efficiency production of plant-derived pigment dopaxanthin in Escherichia coli by combination engineering Metabolic engineering. Microb. cell fact. 2024,23,311.
6. Xiaolong Jiang#, Jing Bai#, Huijing Zhang , Jian Yuan , Gege Lu , Yuhui Wang , Lingyan Jiang ,Bin Liu , Di Huang *, Lu Feng*. Development of an O-polysaccharide based recombinant glycoconjugate vaccine in engineered E. coli against ExPEC O1. Carbohydr Polym, 2022,277: 118796.
7. Jian Yuan#, Xiaolong Jiang#, Huijing Zhang, Jing Bai, Jing Zhang, Yuhui Wang, Gege Lu, Huimin Xu, Huanhuan Liu,* Bin Liu*, Di Huang*. Construction and optimization of a microbial platform for sustainable biosynthesis of poly-N-acetyllactosamine glycoprotein in the cytoplasm for detecting tumor biomarker galectin-3[J]. Green Chemistry, 2021,23(7): 2668-2684.
8. Xiaolong Jiang, Jing Bai, Jian Yuan, Huijing Zhang, Gege Lu, Yuhui Wang, Lingyan Jiang, Bin Liu, Lei Wang, Di Huang,*, Lu Feng*.High efficiency biosynthesis of O-polysaccharide-based vaccines against extraintestinal pathogenic Escherichia coli. Carbohydr Polym, 2021,255: 117475.
9. Xiaolong Jiang, Peng He, Xianni Qi, Yuping Lin,Yongkui Zhang, Qinhong Wang*. High-efficient xylitol production by evolved Candida maltosa adapted to corncob hemicellulosic hydrolysate. J. Chem. Technol. Biotechnol. 91, 2994-2999.
10. 田立岩，李静，江小龙*，宋国田，路福平，戴宗杰，李庆刚，王钦宏*. 原儿茶酸脱羧关键酶挖掘改造优化儿茶酚生物合成. 生物工程学报, 2024, 40(9): 3057-3071.