生物医药

大肠杆菌合成植物天然产物。运用合成生物学技术，通过基因元件挖掘鉴定、人工合成通路设计创建、关键酶改造、代谢调控与发酵优化等手段，实现珍稀药用植物天然产物的微生物高效合成。

Bi, H#., Qu, G#., Wang, S., Zhuang, Y., Sun, Z*., Liu, T*., Ma, Y. 2022. Biosynthesis of a rosavin natural product in Escherichia coli by glycosyltransferase rational design and artificial pathway construction. Metab Eng. 69, 15-25. doi: 10.1016/j.ymben.2021.10.010.
Bi, H#., Wang, S#., Zhou, W., Zhuang, Y., Liu, T*. 2019. Producing gram-scale unnatural rosavin analogues from glucose by engineered Escherichia coli. ACS Synth. Biol. 8, 1931-1940. doi: 10.1021/acssynbio.9b00219.
Zhou, W., Bi, H., Zhuang, Y., He, Q., Yin, H., Liu, T., Ma, Y., 2017. Production of cinnamyl alcohol glucoside from glucose in Escherichia coli. J. Agric. Food Chem. 65, 2129-2135. doi: 10.1021/acs.jafc.7b00076.
Zhou, W., Zhuang, Y., Bai, Y., Bi, H*., Liu T*., Ma Y. 2016. Biosynthesis of phlorisovalerophenone and 4-hydroxy-6-isobutyl-2-pyrone in Escherichia coli from glucose. Microb Cell Fact. 15(1), 149. doi: 10.1186/s12934-016-0549-9.
Bai, Y#., Bi, H#., Zhuang, Y., Liu, C., Cai, T., Liu, X., Zhang, X., Liu, T*., Ma, Y. 2014.  Production of salidroside in metabolically engineered Escherichia coli. Sci Rep. 4, 6640. doi: 10.1038/srep06640.