生物医药

基因编辑技术开发与应用

1.Zhao D, Li J, Li S, Xin X, Hu M, Marcus A. Price, Susan J. Rosser, Bi C, Zhang X. Glycosylase base editors enable C-to-A and C-to-G base changes.Nature Biotechnology.2021, 39:35–40.
2. Ye L, Zhao D, Li J, Wang Y, Li B, Yang Y, Hou X, Wang H, Wei Z, Liu X, Li Y, Li S, Liu Y, Zhang X, Bi C. Glycosylase-based base editors for efficient T-to-G and C-to-G editing in mammalian cells. Nature Biotechnology. 2023, 10.1038/s41587-023-02050-w.（共同一作）
3. Zhao D, Jiang G, Li J, Chen X, Li S, Wang J, Zhou Z, Pu S, Dai Z, Ma Y, Bi C, Zhang X. Imperfect guide-RNA (igRNA) enables CRISPR single-base editing with ABE and CBE. Nucleic Acids Research. 2022, 50:4161-4170.
4. Zhao D, Zhu X, Zhou H, Sun N, Wang T, Bi C, Zhang X. CRISPR-based metabolic pathway engineering. Metabolic Engineering. 2021, 63:148-159.
5. Wu Y, Wan X, Zhao D, Chen X, Wang J, Tang X, Li J, Li S, Sun X, Bi C, Zhang X. AAV-mediated base-editing therapy ameliorates the disease phenotypes in a mouse model of retinitis pigmentosa. Nature Communications. 2023, 14:4923.（共同一作）
6. Sun N, Zhao D, Li S, Zhang Z, Bi C, Zhang X. Reconstructed glycosylase base editors GBE2.0 with enhanced C-to-G base editing efficiency and purity. Molecular Therapy. 2022, 30(7),2452-2463.（共同一作）
7. Wang P, Zhao D, Li J, Su J, Zhang C, Li S, Fan F, Dai Z, Liao X, Mao Z, Bi C, Zhang X. Artificial diploid Escherichia coli by a CRISPR chromosome- doubling technique. Advanced Science. 2023, 10 (7).（共同一作）
8. Wang J, Zhao D, Li J, Hu M, Xin X, Price MA, Li Q, Liu L, Li S, Rosser SJ, Zhang C, Bi C, Zhang X. Helicase-AID. A novel molecular device for base editing at random genomic loci. Metabolic Engineering. 2021, 67:396-402.（共同一作）
9. Zhu X, Zhao D, Qiu H, Fan F, Man S, Bi C*, Zhang X*. The CRISPR/Cas9-facilitated multiplex pathway optimization (CFPO) technique and its application to improve the Escherichia coli xylose utilization pathway. Metabolic Engineering. 2017, 43:37-45.（共同一作）
10. Zhao D, Yuan S, Xiong B, Sun H, Ye L, Li J, Zhang X, Bi C. Development of a fast and easy method for Escherichia coli genome editing with CRISPR/Cas9. Microbial Cell Factories. 2016, 15:205.