生物医药

核心工业菌种的创制与产业应用

1、Liu X1, Dong H1, Wang H1, Ren X, Yang X, Li T, Fu G, Xia M, Fang H, Du G, Jin Z, Zhang D. Recent Advances in Genetic Engineering Strategies of Sinorhizobium meliloti. ACS Synth Biol. 2024 Nov 15;13(11):3497-3506.
2、Yang X1, Wang H1, Ding D, Fang H, Dong H, Zhang D. A hybrid RNA-protein biosensor for high-throughput screening of adenosylcobalamin biosynthesis. Synth Syst Biotechnol. 2024 Apr 13;9(3):513-521.
3、Liu G1, Wang H1, Tong B1, Cui Y, Vonesch SC, Dong H, Zhang D. An Efficient CRISPR/Cas12e System for Genome Editing in Sinorhizobium meliloti. ACS Synth Biol. 2023 Mar 17;12(3):898-903.
4、Dong H1, Wang H1, Fu S, Zhang D. CRISPR/Cas tools for enhancing the biopreservation ability of lactic acid bacteria in aquatic products. Front Bioeng Biotechnol. 2022 Dec 23;10:1114588.
5、Liu L, Ding D, Wang H, Ren X, Lee SY, Zhang D. Balancing Cell Growth and Product Synthesis for Efficient Microbial Cell Factories. Adv Sci (Weinh). 2025 Oct;12(40):e10649.
6、Cui Y1, Dong H1, Tong B, Wang H, Chen X, Liu G, Zhang D. A versatile Cas12k-based genetic engineering toolkit (C12KGET) for metabolic engineering in genetic manipulation-deprived strains. Nucleic Acids Res. 2022 Aug 26;50(15):8961-8973.

1、张大伟；王会颖；董会娜；刘璇；丁冬芹；一种人工合成启动子PH及其在产维生素B12菌株中的应用，2025-02-06，中国，ZL202510132997.4。
2、张大伟；王会颖；董会娜；刘璇；丁冬芹；一种人工合成启动子Pw及其在产维生素B12菌株中的应用，2025-02-06，中国，ZL202510132996.X。
3、张大伟；王会颖；敲除转录因子的苜蓿中华根瘤菌菌株及构建方法和应用，2025-01-24，中国，ZL202510117135.4。

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