论文著作：
[1] Xin-Xin Zhu, Wen-Qing Zheng, Zi-Wei Xia, Xin-Ru Chen, Tian Jin, Xu-Wei Ding, Fei-Fei Chen, Qi Chen, Jian-He Xu, Xu-Dong Kong*, Gao-Wei Zheng*. Evolutionary Insights into the Stereoselectivity of Imine Reductases Based on Ancestral Sequence Reconstruction. Nat. Commun. 2024, 15, 10330.(IF: 14.7)
[2] Zhen-Yu Zhu, Min Shi, Chen-Lin Li, Yun-Fei Gao, Xin-Yuan Shen, Xu-Wei Ding, Fei-Fei Chen, Jian-He Xu, Qi Chen*, Gao-Wei Zheng*. An Engineered Imine Reductase for Highly Diastereo- and Enantioselective Synthesis of β-Branched Amines with Contiguous Stereocenters. Angew. Chem. Int. Ed. 2024, e202408686. (IF: 16.8)
[3] Chun-Yu Gao, Gui-Ying Yang, Xu-Wei Ding, Jian-He Xu, Xiaolin Cheng*, Gao-Wei Zheng*, Qi Chen*. Engineering of Halide Methyltransferase BxHMT through Dynamic Cross-Correlation Network Analysis. Angew. Chem. Int. Ed. 2024, e202401235. (IF: 16.8)
[4] Fei-Fei Chen#, Xue-Feng He#, Xin-Xin Zhu, Zhi Zhang, Xin-Yuan Shen, Qi Chen Q, Jian-He Xu*, Nicholas J Turner*, Gao-Wei Zheng*. Discovery of an Imine Reductase for Reductive Amination of Carbonyl Compounds with Sterically Challenging Amines. J. Am. Chem. Soc. 2023, 145 (7), 4015-4025. (IF: 14.4)
[5] Wen-Qing Zheng, Xin-Xin Zhu, Zheng Zhu, Tairan Yang, Lifen Zheng, Rui Pan, Shenlin Wang, Lixin Zhang, Qi Chen, Jian-He Xu, Yongtao Xie*, Gao-Wei Zheng*. Access to Axially Chiral Biaryl Benzylamines via Ancestral Enzyme-Enabled Reductive Amination Desymmetrization. ACS Catal. 2025, 15, 1522−1531. (IF: 13.9)
[6] Xu-Wei Ding, Jing Rong, Ze-Peng Pan, Xin-Xin Zhu, Zhen-Yu Zhu, Qi Chen, Zhi-Jun Zhang, Jian-He Xu, Chun-Xiu Li, Gao-Wei Zheng*. De Novo Multienzyme Synthetic Pathways for Lactic Acid Production. ACS Catal. 2024, 14, 4665-4674. (IF: 13.9)
[7] Qi Chen#, Bo-Bo Li#, Lilan Zhang#, Xin-Ru Chen, Xin-Xin Zhu, Fei-Fei Chen, Min Shi, Chun-Chi Chen, Yu Yang, Rey-Ting Guo*, Weidong Liu, Jian-He Xu, Gao-Wei Zheng*. Engineered Imine Reductase for Larotrectinib Intermediate Manufacture. ACS Catal. 2022, 12: 14795–14803. (IF: 13.9)
[8] Dong-Hao Wang#, Qi Chen#, Sai-Nan Yin#, Xu-Wei Ding, Yu-Cong Zheng, Zhi Zhang, Yu-Hui Zhang, Fei-Fei Chen*, Jian-He Xu*, and Gao-Wei Zheng*. Asymmetric Reductive Amination of Structurally Diverse Ketones with Ammonia Using a Spectrum-Extended Amine Dehydrogenase.ACS Catal. 2021, 11, 14274–14283.(IF: 13.9)
[9] Fei-Fei Chen, Sebastian C. Cosgrove, William R. Birmingham, Juan Mangas-Sanchez, Joan Citoler, Matthew P. Thompson, Gao-Wei Zheng,* Jian-He Xu,* Nicholas J. Turner*. Enantioselective Synthesis of Chiral Vicinal Amino Alcohols Using Amine Dehydrogenases.ACS Catal. 2019, 9, 11813–11818. (IF: 13.9)
[10] Xu-Min Gong, Zhen Qin, Fu-Long Li, Bu-Bing Zeng, Gao-Wei Zheng*, Jian-He Xu*.Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor.ACS Catal. 2019, 9, 147–153. (IF: 13.9)
郑高伟
上海市
研究领域：
精细化工,生物医药
研究方向：
(1) 新酶的发现与鉴定
基于AI智能搜索、祖先酶重构、宏基因组筛选等策略，获取具有独特功能的酶催化剂。
(2) 酶的创制与改造
通过AI计算、理性设计、定向进化等酶分子改造技术提升其催化性能，满足工业应用需求。
(3) 新酶催化机制与构效关系解析
解析新酶的构效关系，阐明酶的催化机理，为酶分子改造奠定理论基础。
(4) 多酶级联途径的构建与调控
利用合成生物学的方法和思想，构建新颖简洁的体外多酶催化级联反应体系或体内的代谢组装反应体系，并对反应系统进行调控，实现从廉价原料到高值化学品的生物合成。
(5) 酶催化过程的强化与放大
对具有应用价值的酶促反应过程进行优化与放大研究，实现高附加值化学品的绿色工业生产。
(6) 天然化合物和非天然化合物的代谢途径构建
所在单位：
华东理工大学
