论文著作：
18. Zeng, L.F.; Guo, T.X.; Liu, J.X.; Chu, L.L.; Zhang, X.Y.; Fan, D.D.; Bai, Y.P.* Self-assembly of P22 virus-like particles in liquid-liquid phase-separated condensates for enhanced enzyme catalysis. ACS Nano, 2025, 19, 38472−38488.
17. Huanca Nina, M. R.; Zhang, X.Y.; Fan, D.D.; Bai, Y.P.* Quorum sensing based detection and biodegradation of phthalate esters by engineered Escherichia coli and Pseudomonas aeruginosa. Journal of Agricultural and Food Chemistry, 2025, 73, 27990−28004.
16. Liu, J.X.; Deng, X.L.; Huanca Nina, M. R.; Zhang, X.Y.; Fan, D.D.; Bai, Y.P.* Phase-separated dual-enzyme protein condensates e biodegradation of polyethylene terephthalate and phthalate plasticizers. Bioresource Technology, 2026, 439, 133379.
15. Guo, T.X.‡; Zeng, L.F.‡; Liu, J.X.; Zhang, X.Y.; Bai, Y.P.* Phase-separated multienzyme condensates for efficient synthesis of imines from carboxylic acids with enhanced dual-cofactor recycling. International Journal of Molecular Sciences, 2025, 26, 4795.
14. Deng, X.L.; Liu, J.X.; Zhang, X.Y.; Fan, D.D.; Zhang, Z.C.; Bai, Y.P.* Hierarchical porous silica aerogel monoliths for high-flow rate continuous-flow enzyme catalysis. ACS Sustainable Chemistry & Engineering, 2025, 13, 16, 5852–5863.
13. Yuan, P.Y.‡; Wang, Q.‡; Deng, X.L.; Zhang, X.Y.; Fan, D.D.; Bai, Y.P.* Coimmobilized dual enzymes in a continuous flow reactor for the efficient synthesis of optically pure γ/δ-lactones. ACS Applied Materials & Interfaces, 2025, 17, 1, 867–879.
12. Liu, J.X.;Chen, J.X.;Zhang,X.Y.; Fan, D.D.; Bai, Y.P.* Enhanced cofactor recycling and accelerated reaction rate via liquid-liquid phase separation in dual-enzyme condensates. Chinese Journal of Catalysis, 2025, 69, 135–148.
11. Chu, Liliang; Zhang, X.Y.; Fan, D.D.; Bai, Y.P.* Dual-enzyme catalyzed stereoselective synthesis of chiral aromatic polysubstituted γ‑butyrolactones. ACS Catalysis, 2024, 14, 17276-17285.
10. Han, Z.Y.; Huanca Nina, M. R.; Zhang, X.Y.; Huang, H.Y.; Fan, D.D.; Bai, Y.P.* Discovery and characterization of two novel polyethylene terephthalatehydrolases: one from a bacterium identified in human feces and one fromthe Streptomyces genus. Journal of Hazardous Materials, 2024, 472, 134532.
9. Chu, L.L‡; Zhang, X.Y.‡; Li, J.N.; Deng, X.L.; Wu, M.; Cheng, Y.; Zhu, W.P.; Qian, X.H.; Bai, Y.P.* Continuous-flow synthesis of polysubstituted γ-butyrolactones via enzymatic cascade catalysis. Chinese Chemical Letters, 2024, 35, 108896.
8. Deng, X.L. ‡; Fan, M. ‡; Wu, M; Zhang, X.Y.; Cheng, Y.; Xia, J.Y.; Zhuang, Y.P.; Zhu, W.P.; Qian, X.H.; Bai, Y.P.* Continuous-flow enzymatic synthesis of chiral lactones in a three-dimensional microfluidic reactor. Chinese Chemical Letters, 2024, 35, 108684.
7. Qian, Y.Y.‡; Chu, L.L.‡; Zhang, X.Y.‡; Lu, Z.W.; Bai, Y.P.* Stereoselective synthesis of structurally diverse (S)-lactams via an engineered amine dehydrogenase. Advanced Synthesis & Catalysis, 2022, 364(24), 4289-4299.
6. He, J.W.#; Zhang, X.Y.#; Qian, Y.Y.; Wang, Q.Y.; Bai, Y.P.* An engineered quorum-sensing-based whole-cell biosensor for active degradation of organophosphates. Biosensors & Bioelectronics, 2022, 206, 114085.
5. Li, J.W.‡; Huanca Nina, M.R.‡; Zhang, X.Y.‡, Bai, Y.P.* Engineering transcription factor XylS for sensing phthalic acid and terephthalic acid: an application for enzyme evolution. ACS Synthetic Biology, 2022, 11(3), 1106-1113.
4. Zhang, Y.Q.; Feng, T.T.; Cao, Y.F.; Zhang, X.Y.; Wang, T.; Huanca Nina, M.R.; Wang, L.C.; Yu, H.L.; Xu, J.H.; Ge, J.*; Bai, Y.P.* Confining enzyme clusters in bacteriophage P22 enhances cofactor recycling and stereoselectivity for chiral alcohol synthesis. ACS Catalysis, 2021, 11, 16, 10487–10493.
3. Huang, H.; Zhang, X.Y.; Zhao, Y.L.; Xu, D.S.; Bai, Y.P.* Biodegradation of structurally diverse phthalate esters by a newly identified esterase with catalytic activity toward di(2-ethylhexyl) phthalate. Journal of Agricultural and Food Chemistry, 2019, 67 (31): 8548-8558.
2. Chen, M.; Zhang, X.Y.; Zhang, C.; Zheng, Y.C.; Pan, J.; Xu, J.H.*; Bai, Y.P.* Efficient stereoselective synthesis of structurally diverse γ-/δ-lactones using an engineered carbonyl reductase. ChemCatChem, 2019, 11, 2600-2606.
1. Huang, M.T.#; Bai, Y.P.#; Sjostrom, S.L.; Hallström, B.M.; Liu, Z.H.; Petranovic, D.; Uhlén, M.; Joensson, H.N.; Andersson-Svahn, H.; Nielsen, J.*, Microfluidic screening and whole-genome sequencing identifies mutations associated with improved protein secretion by yeast. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112(34): 4689-4696.
白云鹏
上海市
研究领域：
精细化工,生物医药
研究方向：
面向化工、制药和环境领域的需求，聚焦微化工反应技术创新，研究跨尺度分子传递与反应的科学问题，开展催化剂、反应工程到产业应用的系统创新，实现环境友好的生物制造。
· 新酶创制：发展高通量酶定向进化技术，构建新的酶催化反应，实现手性化合物的高效合成和重大环境污染物的高效降解。
· 多酶催化：发展基于蛋白自组装的非均相多酶催化体系，研究纳米效应调控酶催化反应的机制，开发非生物元件强化的人工生物杂合体系。
· 连续反应：设计构建微反应芯片和微反应器，开发连续流酶催化体系，探索体外多酶级联连续反应规律和产业应用。
所在单位：
华东理工大学
