生物医药

食品营养与安全
1.食品功能因子的生理活性评价
2.食源性热加工有害物毒理及安全性评价
3.特殊医学用途全营养食品、发酵食品开发

1. Yuwen Liu#, Ran Zhang, Jiaqi Zou, Hao Yin, Mengyao Zhao*, Liming Zhao* (2024). The impact of chitooligosaccharides with a certain degree of polymerization on diabetic nephropathic mice and high glucose-damaged HK-2 cells. Food Science & Nutrition. 12, 4173-4184.
2. Yuan Li, Jiaqi Zou, Hao Yin, Mengyao Zhao*, Liming Zhao*(2024). The Preventative Effect of Chitooligosaccharides against Chronic Alcoholic Liver Disease by Regulating Alcohol Metabolism, Fatty Acid Metabolism, and Intestinal Barrier Damage. Journal of Food Biochemistry. 1323706.
3. Xinye Zhuang#, Mengyao Zhao#, Xiaoguo Ji, Sihan Yang, Hao Yin, Liming Zhao*(2023). Chitobiose exhibited a lipid-lowering effect in ob/ob−/− mice via butyric acid enrolled liver–gut crosstalk. Bioresour. Bioprocess. 10, 79.
4. Mengyao Zhao#, Boya Zhang, Linlin Deng, Liming Zhao* (2023). Acrylamide induces neurotoxicity in zebrafish (Danio rerio) via NLRP3-mediated pyroptosis. The Science of the total environment, 165208 .
5. Zhuoyu Li#, Mengyao Zhao#, Xiaoguo Ji, Liqiang Fan, Liming Zhao*(2023). Alginate oligosaccharides improve high-fat induced hepatic steatosis via PGC-1α-mediated lipophagy and fatty acid β-oxidation pathway. Journal of Functional Foods. 105825.
6. Mengyao Zhao#, Boya Zhang, Linlin Deng, Liming Zhao*(2022). Acrylamide Induces Neurotoxicity in SH-SY5Y Cells via NLRP3-mediated Pyroptosis. Molecular Neurobiology. 60: 596-609.
7. 叶晗,李炎鑫,赵梦瑶,等.热风干燥海带含水量近红外光谱预测模型建立及品质评价[J]. 食品科技, 2022, 47(10): 252-259.
8. Jiangshan You#, Mengyao Zhao#, Shumin Chen, Lihua Jiang, Shuhong Gao, Hao Yin* and Liming Zhao* (2022), Effect of chitooligosaccharides with a specifc degree of polymerization on multiple targets in T2DM mice. Bioresour. Bioprocess. 9:94.
9. Mengyao Zhao#, Linlin Deng, Xiaoxuan Lu, Liqiang Fan, Yang Zhu, Liming Zhao* (2022). The involvement of oxidative stress, neuronal lesions, neurotransmission impairment, and neuroinflammation in acrylamide-induced neurotoxicity in C57/BL6 mice. Environ Sci Pollut Res Int. 29(27):41151-41167.
10. Shumin Chen, Xiaoguo Ji, Mengyao Zhao, Jiayang Jin, Haiping Zhang*, Liming Zhao* (2022). Construction of chitooligosaccharide-based nanoparticles of pH/redox cascade responsive for co-loading cyclosporin A and AZD9291. Carbohydrate Polymers. 291, 119619.
11. Linlin Deng#, Mengyao Zhao*, Yanan Cui, Quanming Xia, Lihua Jiang, Hao Yin*, Liming Zhao*(2022). Acrylamide induces intrinsic apoptosis and inhibits protective autophagy via the ROS mediated mitochondrial dysfunction pathway in U87-MG cells. Drug Chem Toxicol. 45(6):2601-2612.
12. Chunfeng Zhu#, Mengyao Zhao*, Liqiang Fan, Xuni Cao, Quanming Xia, Jiachun Zhou, Hao Yin, Liming Zhao*(2021). Chitopentaose inhibits hepatocellular carcinoma by inducing mitochondrial mediated apoptosis and suppressing protective autophagy. Bioresour. Bioprocess. 8, 4.
13.  Xin Shen, Xinyi Liang, Xiaoguo Ji, Jiangshan You, Xinye Zhuang, Yudong Song, Hao Yin, Mengyao Zhao*, Liming Zhao*(2021). CD36 and DGAT2 facilitate the lipid-lowering effect of chitooligosaccharides via fatty acid intake and triglyceride synthesis signaling. Food Funct. 12(18):8681-8693.
14.  Mengyao Zhao, Shumin Chen, Xiaoguo Ji, Xingtong Shen, Jiangshan You, Xinyi Liang, Hao Yin, Liming Zhao* (2021). Current innovations in nutraceuticals and functional foods for intervention of non-alcoholic fatty liver disease. Pharmacological Research. 105517.
15.  Xiaoguo Ji, Mai Chen, Mengyao Zhao, Yudong Song, Yong Lin, Hao Yin*, Liming Zhao*(2021). Effects of chitooligosaccharides on the rebalance of gut microorganisms and their metabolites in patients with nonalcoholic fatty liver disease. Journal of Functional Foods, 77, 104333.版社。ISBN 978-7-5184-2138-1。

近年来主持多项包括国家自然科学基金青年基金、上海市浦江人才计划、国家重点研发计划子课题、上海市自然基金面上项目等在内的多个省部级项目、人才计划。
1. 主持上海市自然基金面上项目（23ZR1417300），“肠道菌群-肝脏轴”介导功能寡糖调节脂代谢中的分子机制及益生效应，2023-2026；
2. 主持国家重点研发计划子课题（2019YFD0901803-02），水产品智能化加工装备与关键技术，2019-2022;
3. 主持国家自然科学基金青年基金（31801668），食源性有害物丙烯酰胺通过NLRP3炎症小体激活介导神经毒性的机制探索，2019-2021;
4. 主持中国博士后科学基金特别资助（2019T120314），单一聚合度壳寡糖对非酒精性脂肪肝的干预效果及机制研究，2019-2021；
5. 主持上海市浦江人才计划A类（18PJ1401900），NLRP3炎症小体介导的细胞焦亡在食源性有害物丙烯酰胺神经致毒中的机制研究，2018-2020;
6. 主持中国博士后科学基金面上资助（2017M621392），单一聚合度壳寡糖促体内外肝癌细胞凋亡机制研究，2017-2019;