生物医药

1. 食品亲水胶体
基于多糖、蛋白等食品亲水胶体的物性表征，研究其在功能性食品、益生菌及功能生物材料等领域的应用。
2. 生物活性肽
基于深度学习的生物活性肽高通量筛选和生物制造，开发功能生物活性肽产品。
3. 益生菌
功能益生菌发掘、高密度发酵及冻干保护剂开发。

1. Yuan Zou, Kum-Song. Ro, Chentian Jiang, Deyi Yin, Li Zhao, Daihui Zhang, Lei Du*, Jingli Xie. The anti-hyperuricemic and gut microbiota regulatory effects of a novel purine assimilatory strain, Lactiplantibacillus plantarum X7022, European Journal of Nutrition. 2023, DOI: 10.1007/s00394-023-03291-w.
2. Deyi Yin, Li Zhao, Sijing Deng, Yaqi Xie, Kum-Song Ro, Zeyong Yang, Lei Du*, JingLi Xie*, DongZhi Wei. Lactiplantibacillus plantarum X7022 plays roles on aging mice with memory impairment induced by D-galactose through restoring neuronal damage, relieving inflammation and oxidative stress, Probiotics and Antimicrobial Proteins. 2024, https://doi.org/10.1007/s12602-023-10208-w.
3. Kum-Song Ro, Li Zhao, Yangting Hu, Minli Ge, Lei Du*, Jingli Xie*. Anti-hyperuricemic properties and mechanism of Lactiplantibacillus plantarum X7023. Process Biochemistry. 2024, 136:26-37.
4. Dewei Xie, Yaling Shen, Eezeng Su, Lei Du*, Jingli Xie*, Dongzhi Wei. Anti-hyperuricemic, nephroprotective, and gut microbiota regulative effects of separated hydrolysate of alpha-Lactalbumin on potassium oxonate- and hypoxanthine-induced hyperuricemic mice. Molecular Nutrition & Food Research. 2023, 67(1), 2200162.
5. Lisong Hu, Yitong Xie, Shishuai Gao, Xiaoyu Shi, Chenhuan Lai, Daihui Zhang*, Chuanwei Lu, Yi Liu, Lei Du*, Xuezhi Fang*, Fen. Xu, Chunpeng Wang, Fuxiang Chu. Strain-induced orientation facilitates the fabrication of highly stretchable and tough xylan-based hydrogel for strain sensors. Carbohydrate Polymers. 2023, 312, 120827.
6. Chentian Jiang, Yafan Liu, Yijia Wang, Erzheng Su, Lei Du*, Ya-Jie Tang, Jingli Xie*, Dongzhi Wei. Hypolipidemic effects of the fermented soymilk with a novel Lactiplantibacillus plantarum strain X7021 on mice via modulating lipid metabolism and gut microbiota. International Journal of Food Science and Technology. 2022, 57(7): 4555-4565.
7. Lei Du, Kum-Song Ro, Yiji Zhang, Ya-Jie Tang, Wanbang Li, Jingli Xie*, Dongzhi Wei*. Effects of Lactiplantibacillus plantarum X7021 on physicochemical properties, purines, isoflavones and volatile compounds of fermented soymilk. Process Biochemistry. 2022, 113: 150-157.
8. Dewei Xie, Yunsheng Gao,Lei Du*, Yaling Shen, Jingli Xie, Dongzhi Wei. Effect of flavorzyme-modified soy protein on the functional properties, texture and microstructure of Mozzarella cheese analogue. Journal of Food Processing and Preservation. 2021, 45(11): e15963.
9. Lei Du, Chandra Sekhar Biswas, Yuhang Wu, Amin Ghavaminejad, Florian J. Stadler. Small and large amplitude oscillatory shear behavior of supramolecular gels based on dopamine-boronic acid interactions.Journal of Rheology. 2019, 63 (3), 391-404.
10. Lei Du, Amin Ghavaminejad, Zhi-chao Yan, Chandra Sekhar Biswas, Florian J. Stadler. Effect of a functional polymer on the rheology and microstructure of sodium alginate. Carbohydrate Polymers, 2018, 199: 58-67.
11. Lei Du, Amin Ghavaminejad, Mohammad Vatankhah-varnoosfaderani, Florian. J. Stadler. Study of the interactions of zwitterions and carbon nanotubes by nonlinear rheology in aqueous environment. Langmuir,2019, 35:1964-1972.
12. Lei Du, Tom Brenner, Jingli Xie, Shingo Matsukawa. A study on phase separation behavior in kappa/iota carrageenan mixtures by micro DSC, rheological measurements and simulating water and cations migration between phases. Food Hydrocolloids, 2016, 55: 81-88.

[1] 谢静莉，方明，李鹏，吴艳玲，杜磊，魏东芝. 降血压多肽，ZL 2013101240332.

（1） 国家自然科学基金青年基金项目(31801489)，主持。
（2） 上海市自然科学基金面上项目(21ZR1416200)，主持。
（3） 广东省水产品加工与安全重点实验室开放基金课题(GDPKLAPPS2001)，主持。
（4） 微生物技术国家重点实验室（山东大学）开放课题(62450004042010)，主持。
（5） 国家自然科学基金面上项目(21574086)，项目骨干。

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