生物医药

微生物天然产物化学：基于自主构建高内涵菌种库资源，利用生信分析技术进行微生物抗感染天然产物基因组挖掘，结合高通量生物活性筛选模型及LC-MS/MS、NMR层面排重技术，快速发现结构新颖的小分子活性成分；并在此基础上进行生物合成途径解析及体内外药效研究。

1.  Guoliang Zhu#, Wupeng Yan#, Xinye Wang#, Ronghai Cheng#, Nathchar Naowarojna, Kun Wang, Jun Wang, Heng Song, Yuyang Wang, Hairong Liu, Xuekui Xia, Catherine E. Costello, Xueting Liu*, Lixin Zhang*, Pinghua Liu*. Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues. JACS Au, 2022, 2, 1686–1698
2.  Yuwei Xia#, Guoliang Zhu#, Xingwang Zhang#, Shengying Li, Lei Du*, and Weiming Zhu*, Biosynthesis of 4-Acyl-5-aminoimidazole Alkaloids Featuring a New Friedel–Crafts Acyltransferase. JACS, 2023, 145, 26308–26317
3.  Guoliang Zhu#, Chengjian Hou#, Weize Yuan, Zhenzhen Wang, Jingyu Zhang, Lan Jiang, Loganathan Karthik, Bixiao Li, Biao Ren, Kangjie Lv, Wanying Lu, Zhanren Cong, Huanqin Dai, Tom Hsiang, Lixin Zhang, Xueting Liu*. Molecular networking assisted discovery and biosynthesis elucidation of the antimicrobial spiroketals epicospirocins. Chem. Commun., 2020, 56, 10171–10174.
4.  Guoliang Zhu#, Fandong Kong#, Yi Wang, Peng Fu*, and Weiming Zhu*, Cladodionen, a Cytotoxic Hybrid Polyketide from the Marine-Derived Cladosporium sp. OUCMDZ-1635, Mar. Drugs, 2018, 16: 71–78
5.  Lan Jiang#, Guoliang Zhu#, Jianying Han, Chengjian Hou, Xue Zhang, Zhixin Wang, Weize Yuan, Kangjie Lv, Zhanren Cong, Xinye Wang, Xiangyin Chen, Loganathan Karthik, Huanting Yang, Xuyuan Wang, Gaoyi Tan, Guang Liu, Liya Zhao, Xuekui Xia, Xiangyang Liu, Shushan Gao, Lei Ma, Mei Liu, Biao Ren, Huanqin Dai, Ronald J Quinn, Tom Hsiang*, Jingyu Zhang*, Lixin Zhang, Xueting Liu*. Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi. Appl. Microbiol. Biotech., 2021, 105, 5407–5417.
6.  Wanying Lu#, Guoliang Zhu#, Weize Yuan, Zhaoxi Han, Huanqin Dai, Mostafa Basiony, Lixin Zhang, Xueting Liu, Tom Hsiang, Jingyu Zhang*. Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum. Synth. Syst. Biotechnol., 2021, 6, 446–451.
7.  Kunlai Sun#, Guoliang Zhu#, Jiejie Hao, Yi Wang, Weiming Zhu*, Chemical-epigenetic method to enhance the chemodiversity of the marine algicolous fungus, Aspergillus terreus OUCMDZ-2739, Tetrahedron, 2018, 74: 83–87.
8.  Lan Jiang#, Kangjie Lv#, Guoliang Zhu#, Zhi Lin, Xue Zhang, Cuiping Xing, Huanting Yang, Weiyan Zhang, Zhixin Wang, Chengwei Liu, Xudong Qu, Tom Hsiang, Lixin Zhang, Xueting Liu*, Norditerpenoids biosynthesized by variediene synthase-associated P450 machinery along with modifications by the host cell Aspergillus oryzae, Synth. Syst. Biotechnol., 2022, 7, 1142–1147.

授权专利：
1. 低毒匹马霉素衍生物及其制备方法和应用，授权号：ZL 202110604486.X
2. 来源于植物内生真菌的铁载体类化合物及制备方法与应用，授权号：ZL 202110563340.5
3. 一类二倍半萜骨架化合物及其合成基因及制备方法，授权号：ZL 202110334394.4
4. 一种生产卟啉类化合物的重组菌及生产卟啉类化合物的方法，ZL 201910999107.4
5. 一类来源于植物病原真菌的5-15环二倍半萜化合物及其制备方法与应用，ZL 201910566720.7
6. 一类helminthosporol型倍半萜类化合物及其制备方法与应用，ZL 201910566725.X
7. 来源于链霉菌的碳磷化合物及其制备方法与应用，ZL 201910440511.8
申请中专利：
1.  来源于植物内生真菌的十氢化萘衍生物及制备方法与应用，申请号：202311145602.1
2.  一类5-11双环二倍半萜骨架化合物及其制备，申请号：202110709524.8
3.  一类5-12-5三环二倍半萜骨架化合物及其制备，申请号：202110710008.7

1.  国家自然科学青年基金，81903529，主持
2.  企业横向基金（德州派得宠物食品有限公司），F100-42333-S，主持
3.  国家重点研发计划“合成生物学”重点专项，2020YFA090032，研究骨干
4.  国家重点研发计划“合成生物学”重点专项，2019YFA0906201，研究骨干
5.  上海市科委项目传染病国家实验室上海基地培育（一期），21NL2600100，研究骨干

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