生物医药

真菌合成生物学研究：以食品安全、具有优异蛋白表达和分泌能力及强大代谢能力的丝状真菌里氏木霉为体系，围绕基因表达的信号分子与传递机制、蛋白质分泌系统改造与宿主适配性、生物合成途径优化与代谢流控制开展研究，基于合成生物技术开发细胞工厂，实现外源蛋白（如工业酶制剂、功能蛋白等）、大宗化学品（有机酸L-苹果酸、衣康酸等）等高附加值产品的高效表达与合成，推动绿色生物制造发展，实现高值化利用。

1. Yumeng Chen#, Ziwei Wang#, Cangcang Chen, Sheng Xiao, Jia Lv, Ling Lin, Jiayu Liu, Xinrui Li, Wei Wang*, Dongzhi Wei. Metabolic engineering of filamentous fungus Trichoderma reesei for itaconic acid production. Journal of Agriculture and Food Chemistry. 2025, accept.

2. Jiajia Wang#, Yumeng Chen#, Jiawei Cong, Wei Wang*. Metformin regulates cellulase production in Trichoderma reesei via calcium signaling and mitochondrial function. Microbial cell factory. 2024, 23(1):314.

3. Yumeng Chen, Jiajia Wang, Meng Wang, Ao Han, Xinqing Zhao, Wei Wang*, Dongzhi Wei. Engineering the metabolism and morphology of the filamentous fungus Trichoderma reesei for efficient L-malic acid production. Bioresource Technology. 2023, 387:129629.

4. Yumeng Chen, Ao Han, Meng Wang, Dongzhi Wei, Wei Wang*. Metabolic Engineering of Trichoderma reesei for L-Malic Acid Production. Journal of Agriculture and Food Chemistry. 2023, 71(9):4043-4050.

5. Jing Li#, Yumeng Chen#, Ao Gao, Liujing Wei, Dongzhi Wei, Wei Wang*. Simultaneous Production of Cellulase and β-Carotene in the Filamentous Fungus Trichoderma reesei. Journal of Agriculture and Food Chemistry. 2023, 71(16):6358-6365.

6. Yumeng Chen, Meng Wang, Wei Wang*, Yi Zeng, Xingjia Fan, Maobing Tu, Yushu Ma, Dongzhi Wei, Metabolic engineering for the comprehensive utilization of N, N-dimethylformamide-containing wastewater. Journal of Agriculture and Food Chemistry. 2022, 70(42):13574-13582.

7. Yumeng Chen, Xingjia Fan, Xinqing Zhao, Yaling Shen, Xiangyang Xu, Liu-Jing Wei, Wei Wang*, Dongzhi Wei. cAMP activates calcium signalling via phospholipase C to regulate cellulase production in the filamentous fungus Trichoderma reesei. Biotechnology for Biofuels. 2021, 14:62.

8. Yumeng Chen#, Wei Wang#*, Pei Liu, Aibo Lin, Xingjia Fan, Chuan Wu, Ni Li, Liu-Jing Wei, Dongzhi Wei*. The novel repressor Rce2 competes with Ace3 to regulate cellulase expression in the filamentous fungus Trichoderma reesei. Molecular Microbiology. 2021, 00:1-17.

9. Yumeng Chen#, Aibo Lin#, Pei Liu, Xingjia Fan, Chuan Wu, Ni Li, Liu-Jing Wei, Wei Wang*, Dongzhi Wei. Trichoderma reesei ACE4, a novel transcriptional activator involved in the regulation of cellulase genes during growth on cellulose. Applied and Environmental Microbiology. 2021, 87(15):e0059321.

10. Yumeng Chen#; Chuan Wu#; Xingjia Fan; Xinqing Zhao; Xihua Zhao; Shen Tao; Dongzhi Wei; Wei Wang*, Engineering of Trichoderma reesei for enhanced degradation of lignocellulosic biomass by truncation of the cellulase activator ACE3. Biotechnology for Biofuels. 2020, 13:62.

1.国家自然科学基金青年基金项目，32000050，24万元，主持。
2. “绿色生物制造”国家重点研发计划子课题，2021YFC2100300，143.7万元，主持。
3. 中国博士后科学基金第66批面上项目，2019M661402，8万元，主持。
4. 上海市自然科学基金面上项目，23ZR1414800，20万元，主持。
5. 华东理工大学基本科研业务费，JKF01211514，8万元，主持。
6. 上海市科技兴农重点攻关项目，2021-02-08-00-12-F00758，95万元，参与。