生物医药

1. 功能碳水化合物的绿色生物合成
2. 生物基材料化学品的绿色生物合成
3. 光控动态调控基因回路的设计与构建
4. 谷氨酸棒杆菌、假单胞菌的基因编辑及调控工具开发

[1] Chen Deng, Ruijie Xin, Xingjian Li, Jie Zhang, Liqiang Fan, Yongjun Qiu, Liming Zhao*. Optogenetic control of Corynebacterium glutamicumgene expression. Nucleic Acids Research. 2024.11
[2] Yanan Cui#, Chen Deng#, Liqiang Fan, Yongjun Qiu, Liming Zhao*, Progress in the biosynthesis of bio-based PET and PEF polyester monomers. Green Chemistry. 2023.10
[3]Chen Deng, Mengxuan Zhao, Qiong Zhao, Liming Zhao*， Advances in green bioproduction of marine and glycosaminoglycan oligosaccharides. Carbohydrate Polymers. 2023.03
[4]Chunyu Ma, Chunyue Zhang, Liqiang Fan, Chen Deng*, Liming Zhao*,De novo 2′-fucosyllactose bioproduction through modular engineering of a novel Escherichia coliK12-derived strain. Food Bioengineering.2023.09
[5]Chen Deng, Yaokang Wu, Xueqin Lv, Jianghua Li, Yanfeng Liu, Guocheng Du, Jian Chen, Long Liu*. Refactoring transcription factors for metabolic engineering. Biotechnology Advances. 2022.08
[6] Chen Deng, Xueqin Lv, Jianghua Li, Hongzhi Zhang, Yanfeng Liu, Guocheng Du, Rodrigo Ledesma Amaro, Long Liu*. Synergistic improvement of N-acetylglucosamine production by engineering transcription factors and balancing redox cofactors. Metabolic Engineering. 2021.07
[7] Jiangong Lu, Yaokang Wu, Chen Deng, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu*, Model-based dynamic engineering of Escherichia coli for N-acetylglucosamine overproduction. Biotechnol Notes. 2022.02
[8] Meng Chai, Chen Deng, Qi Chen, Wei Lu, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu*. Synthetic Biology Toolkits and Metabolic Engineering Applied in Corynebacterium glutamicum for Biomanufacturing. ACS Synthetic Biology. 2021.12
[9] Qiong Zhao, Liqiang Fan, Chen Deng, Chunyu Ma, Chunyue Zhang*, Liming Zhao*, Bioconversion of chitin into chitin oligosaccharides using a novel chitinase with high chitin-binding capacity. International journal of biological macromolecules. 2023.06
[10] Jinqi Shi, Chen Deng, Chunyue Zhang, Shu Quan, Liqiang Fan*, Liming Zhao*, Combinatorial metabolic engineering of Escherichia coli for de novo production of structurally defined and homogeneous Amino oligosaccharides. Synthetic and Systems Biotechnology. 2024.05
[11] Chen Deng, Xueqin Lv, Jianghua Li, Hongzhi Zhang, Yanfeng Liu , Guocheng Du, Rodrigo Ledesma Amaro, Long Liu*. Synergistic improvement of N-acetylglucosamine production by engineering transcription factors and balancing redox cofactors. Metabolic Engineering. 2021.07
[12]Chen Deng , Xueqin Lv , Jianghua Li , Yanfeng Liu, Guocheng Du, Long Liu*. Development of a DNA double-strand break-free base editing tool in Corynebacterium glutamicum for genome editing and metabolic engineering. Metabolic Engineering Communications. 2020.12
[13]Chen Deng, Xueqin Lv, Yanfeng Liu, Jianghua Li, Wei Lu, Guocheng Du, Long Liu*. Metabolic engineering of Corynebacterium glutamicum S9114 based on whole-genome sequencing for efficient N-acetylglucosamine synthesis. Synthetic and Systems Biotechnology. 2019.06
[14]Chen Deng, Xueqin Lv, Jianghua Li, Yanfeng Liu, Guocheng Du, Rodrigo Ledesma Amaro, Long Liu*. Synthetic repetitive extragenic palindromic (REP) sequence as an efficient mRNA stabilizer for protein production and metabolic engineering in prokaryotic cells. Biotechnology and Bioengineering. 2019.01 (封面文章)
[15] Chen Deng, Jianghua Li, Hyun-Dong Shin, Guocheng Du, Jian Chen, Long Liu*. Efficient expression of cyclodextrin glycosyltransferase from Geobacillus stearothermophilus in Escherichia coli by promoter engineering and downstream box evolution. Journal of Biotechnology.2018.01

[1] 赵黎明,邓琛,辛瑞杰,崔亚楠.一种生产几丁寡糖的重组谷氨酸棒杆菌及构建方法与应用，申请号：202310236792.1
[2] 赵黎明,邓琛, 崔亚楠，一株合成2，5-呋喃二甲酸的蒙氏假单胞菌及其应用，申请号：202210891245.2
[3] 赵黎明,邓琛,辛瑞杰,李行健，张婕，一种蓝光响应的谷氨酸棒杆菌工程菌株及其构建方法与应用，申请号2024116102687
[4] 赵黎明,邓琛,李行健, 一种用于生产硫酸软骨素的重组谷氨酸棒杆菌及其构建方法与应用，申请号2024116102704
[5] 刘龙，邓琛，卢健行，刘长峰，卢建功，李江华，堵国成，陈坚，一种促进N-乙酰氨基葡萄糖生产的RamA转录因子突变体及其应用，授权公告号：CN110885364B.
[6] 刘龙，邓琛，卢健行，刘长峰，卢建功，李江华，堵国成，陈坚，一种促进N-乙酰氨基葡萄糖生产的蛋白质起始因子IF3突变体及其应用，授权公告号：CN110964090B.
[7] 刘龙，邓琛，卢健行，刘长峰，卢建功，李江华，堵国成，陈坚，一种高产乙酰氨基葡萄糖的重组谷氨酸棒杆菌及其应用，授权公告号：CN110195036B.
[8] 刘龙，堵国成，陈坚，李江华，邓琛，一种提高外源基因mRNA的重复性回文序列及其应用，授权公告号：CN108531496B.
[9] 刘龙，堵国成，陈坚，李江华，邓琛，一种生产N-乙酰氨基葡萄糖的谷氨酸棒杆菌及其应用，授权公告号：CN108424870B.

2024年上海市“科技创新行动计划”合成生物学领域项目
2023年上海市“晨光计划”
2023年国家自然科学基金青年项目
2022年国家重点研发计划重点专项子课题
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中国博士后科学基金第71批面上资助
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