生物医药

（1）输血相容性检测新技术及免疫血液学与临床输血研究
围绕精准输血的临床需求，以开发和优化输血相容性快速检测技术为核心，探索高效、精准的检测方法，助力提升输血安全性与有效性。
（2）基于天然蚕丝蛋白膜的新型生物传感平台研究
利用天然蚕丝蛋白膜的独特材料特性及三维多层孔隙结构，构建依赖生物分子特异性识别机制的传感界面，开展全血样本中多种生物标志物的可视化检测研究。
（3）生物标志物多样本、多参数并行检测研究
聚焦多重检测需求，开发并优化微流控芯片技术，进行生物标志物的多样本、多参数并行检测研究。通过
芯片结构设计、驱动策略优化及试剂配比改良，实现微量生物样本中多重标志物的高精度、自动化分析。

[1] Shaohua Ding, Hongmei Wang, Yezhou Chen, Jingjing Tian, Feiran Wu, Yujue Wang, Zebin Hu, Shengbao Duan*. Scalability and application of silk fiber paper as a natural-based matrix for immunosensing. Applied Materials Today, 2025 (42), 102535. (SCI)
[2] Ainong Sun; Yujue Wang; Yonglun Wu; Feng Ge; Xin Ye; Hongmei Wang; Yezhou Chen; Shaohua Ding; Jingjing Tian; Qiao Li; Yanting Liao; Shengbao Duan*. Analysis of cluster of differentiation 36 expression and genetic variation in blood donors in Zhongshan City, China. Asian Journal of Transfusion Science. 2024, DOI: 10.4103/ajts.ajts_139_22 (SCI)
[3] Biao Wang, Lei Wang, Wenchang Xu, Shaohua Ding, Shengbao Duan & Wenbo Cheng*. Red Blood Cell Antigen Typing Based on Image Processing and Machine Learning.  ICSS 2023. Communications in Computer and Information Science, vol 1844. Springer, Singapore. DOI: 10.1007/978-981-99-4402-6_17
[4] Ning Ma, Lu Wang, Lele Zhou, Yizhen Wan, Shaohua Ding, Weiping Qian*. Analysis of the interaction between chitosan with different molecular weights and casein based on optical interferometry. Food Hydrocolloids. 2023(137), 108386. (SCI)
[5] Shaohua Ding, Shengbao Duan, Yezhou Chen, Jinsong, Xie, Jingjing Tian, Hongmei Wang*. Centrifugal microfluidic platform with digital image analysis for parallel red cell antigen typing. Talanta, 2023 (252), 123856 (SCI)
[6] Hongmei Wang, Shengbao Duan, Yezhou Chen, Huan Liu, Jingjing Tian, Feiran Wu, Ziqian Du, Longhai Tang, Yong Li, Shaohua Ding*. Study on a Natural Silk Cocoon Membrane-Based Versatile and Stable Immunosensing Platform via Directional Immunoaffinity Recognition. ACS Omega, 2022, 2c04777 (SCI)
[7] Shuangshi Wei, Shengbao Duan, Xiaomei Liu, Hongmei Wang, Shaohua Ding, Yezhou Chen, Jinsong Xie, Jingjing Tian, Nong Yu, Pingju Ge, Xinglin Zhang, Xiaohong Chen, Yong Li, Qinglin Meng*. Chicken Egg Yolk Antibodies (IgYs）block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2. International Immunopharmacology, 2021(90), 107172 (SCI)
[8] Hongmei Wang; Shengbao Duan; Mingyuan Wang; Shuangshi Wei; Yezhou Chen; Wei Chen; Yong Li; Shaohua Ding*; Silk cocoon membrane-based immunosensing assay for red blood cell antigen typing, Sensors and Actuators B: Chemical, 2020, 320: 0-128376. (SCI))
[9] Shengbao Duan; Mingyuan Wang; Shaohua Ding; Yezhou Chen; Shuangshi Wei; Wei Chen; Chun Zhang; Yong Li; Hongmei Wang*; Application of lyophilised human platelets for antibody detection in solid phase red cell adherence assay, Journal of Immunological Methods, 2020, 487: 0-112868. (SCI)
[10] Hua Chai, Jiarui Xu, Jianhua Xu, Shaohua Ding, Yuguo Tang, Peng Miao*. Star trigon structure-aided DNA walker for amplified electrochemical detection of DNA. 2019(99), 51-55.
[11] Shaohua Ding; Zhipeng Gu; Ruhong Yan; Yuguo Tang; Peng Miao*. A novel mode of DNA assembly at electrode and its application to protein quantification, Analytica Chimica Acta, 2018, 1029: 24-29. (SCI)
[12] Haiwen Li, Ligang Wu, Wuping Zhou, Keming Jiang, Weiwei Fu, Yuefang Dong, Shi Chen, Cong Liu, Tao Zhang, Shaohua Ding, Shengbao Duan, Yong Li. Microfluidic disk for the determination of human blood types. 2017(23), 5645–5651. (SCI)
[13] Thomas Zapf, Cherng-Wen Darren Tan, Tobias Reinelt, Christoph Huber, Shaohua Ding, Susana Geifman-Shochat, Harald Paulsen, Eva-Kathrin Sinner*. Synthesis and Functional Reconstitution of Light-Harvesting Complex II into Polymeric Membrane Architectures. Angewandte Chemie International Edition, 2015(54), 14664-14668. (SCI)
[14] Hongmei Wang,Yezhou Chen,Shengbao Duan,Jingjing Tian,Yong Li, Shaohua Ding*. Characterization of a Novel Microcarrier Using Magnetized Red Blood Cells with Terminal Aldehydes.Analytical Letters,2016(49), 768-777. (SCI)
[15] Hongmei Wang, Yezhou Chen, Shaohua Ding, Shengbao Duan, Jingjing Tian, Qinglin Meng, Shuangshi Wei, Yong Li. A new approach to detection of incomplete antibodies using hydrogel chromatography medium. Transfusion and Apheresis Science, 2015(53), 337-341.

1. 刘铁梅，李勇，王红梅，李鑫阳，段生宝，陈晔洲，丁少华，田晶晶，王玉珏，一种红细胞保存试剂及其应用，发明专利，ZL202211391365.2
2. 李勇，吴斐然，杜子谦，段生宝，王红梅，陈晔洲，丁少华，魏双施，田晶晶，一种生物反应载体及其制备方法，发明专利，ZL202110076426.5
3. 李勇，丁少华，段生宝，王红梅，吴斐然，杜子谦，陈晔洲，田晶晶，魏双施，一种用于富集循环肿瘤细胞的功能化基底及其制备方法，发明专利，ZL202110076876.4
4. 李勇，王红梅，段生宝，丁少华，魏双施，田晶晶，陈晔洲，吴斐然，杜子谦，一种梅毒抗体检测的免疫传感载体、试剂盒和制备方法，发明专利，ZL202110076842.5
5. 李勇，田晶晶，段生宝，吴斐然，杜子谦，丁少华，陈晔洲，王红梅，魏双施，一种用于蚕丝纤维化的生物活性试剂和方法，发明专利，ZL202110076855.2

1. 国家重点研发计划（2024YFC2422400）
2. 国家科技支撑计划项目（2015BAI28H00）
3. 国家自然科学基金（52103135）
4. 中国科学院科研仪器设备研制项目（YJKYYQ20200037）
5. 吉林省与中国科学院科技合作高技术产业化专项（2023SYHZ0044）
6. 江苏省科技计划项目（BK20130343）
7. 苏州市医疗器械与新医药专项（ZXY2013017）

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