生物医药

1）病原感染精准诊断技术
2）细菌耐药机制研究
3）新型拉曼光谱技术、设备开发与其生物医学应用

1. Jin N, Yang K, Li J, Song Y, Ding A, Sun Y, Li G & Zhang D. (2023). Toxicity Characterization of Environment-Related Pollutants Using a Biospectroscopy–Bioreporter-Coupling Approach: Potential for Real-World Toxicity Determination and Source Apportionment of Multiple Pollutants. Analytical Chemistry.
2. Wang J, Meng S, Lin K, Yi X, Song Y, Xu X, He N, Zhang Z, Hu H, Qie X, Zhang D, Tang Y, Huang W, He J* & Song, Y* (2023). Leveraging single-cell Raman spectroscopy and single-cell sorting for the detection and identification of yeast infections. Analytica Chimica Acta, 1239, 340658.
3. Liu M, Mu J, Gong W, Zhang K, Yuan M, Song Y, Li B, Jin N, Zhang W & Zhang, D. (2022). In Vitro Diagnosis and Visualization of Cerebral Ischemia/Reperfusion Injury in Rats and Protective Effects of Ferulic Acid by Raman Biospectroscopy and Machine Learning. ACS Chemical Neuroscience.
4. Wang P, Song Y, Mei Q, Dong W-F, Li L. Sliver nanoparticles@ carbon dots for synergistic antibacterial activity. Applied Surface Science 2022, 600: 154125.
5. Bai H, Meng S, Xiong C, Liu Z, Shi W, Ren Q, Xia W, Zhao W, Jian G, Song Y, Ni C & Li Z. Preoperative CECT-based Radiomic Signature for Predicting the Response of Transarterial Chemoembolization (TACE）Therapy in Hepatocellular Carcinoma. CardioVascular and Interventional Radiology 2022, 45(10): 1524-1533.
6. Hu H, Wang J, Yi X, Lin K, Meng S, Zhang X, Jiang C, Tang Y, Wang M, He J*, Xu X* & Song Y*. Stain-free Gram staining classification of pathogens via single-cell Raman spectroscopy combined with machine learning[J]. Analytical Methods, 2022, 14(40): 4014-4020.
7. Qie X, Zan M, Gui P, Chen H, Wang J, Lin K, Mei Q, Ge M, Zhang Z, Tang Y, Dong W-F* and Song Y* (2022). "Design, Synthesis, and Application of Carbon Dots With Synergistic Antibacterial Activity." Frontiers in Bioengineering and Biotechnology, 2022, 10.
8. Yuan S., Chen Y, Lin K, Zou L, Lu X, He N, Liu R, Zhang S, Shen D, Song Z, Tong C, Song Y*, Zhang W, Chen L and Sun G (2022). "Single Cell Raman Spectroscopy Deuterium Isotope Probing for Rapid Antimicrobial Susceptibility Test of Elizabethkingia spp." Frontiers in Microbiology, 2022. 13.
9. Gao R, Meng M, Zhou X, Yu M, Li Z, Li J, Wang X, Song Y*, Wang H*, He J*. TRPV1, a novel biomarker associated with lung cancer via excluding immune infiltration". Medcomm, 2022. 3(2): p. e139.
10. Sun J, Zhang Z*, Li H, Yin H*, Hao P, Dai X, Jiang K, Liu C, Zhang T, Yin J, Song Y*, Zhou W, Gao J. Ultrasensitive SERS Analysis of Liquid and Gaseous Putrescine and Cadaverine by a 3D-Rosettelike Nanostructure-Decorated Flexible Porous Substrate. Anal Chem 2022, 94(13): 5273-5283.
11. Jin N, Song Y, Ma R, Li J, Li G, Zhang D. Characterization and identification of microplastics using Raman spectroscopy coupled with multivariate analysis. Anal Chim Acta 2022, 1197: 339519.
12. Yuan S, Chen Y, Song Y, Zou L, Lin K, Lu X, Liu R, Zhang S, Shen D, Song Z, Tang C, Chen L & Sun, G. (2021). Single Cell Raman-Deuterium Isotope Probing for Drug Resistance of Elizabethkingia spp. bioRxiv, 2021-06.
13. He J*, Gao R, Meng M, Yu M, Liu C, Li J, Song Y*, Wang H*. Lysophosphatidic Acid Receptor 6 (LPAR6）Is a Potential Biomarker Associated with Lung Adenocarcinoma. Int J Env Res Pub He 2021, 18(21): 11038.
14. Wang J, Lin K, Hu H, Qie X, Huang WE, Cui Z, Gong Y, Song Y*. In Vitro Anticancer Drug Sensitivity Sensing through Single-Cell Raman Spectroscopy. Biosensor 2021, 11(8): 286.
15. Yi X, Song Y, Xu X, et al. Development of a fast Raman-assisted antibiotic susceptibility test (FRAST）for the antibiotic resistance analysis of clinical urine and blood samples[J]. Analytical Chemistry, 2021, 93(12): 5098-5106.
16. Chen J, Lim B, Steel H, Song Y.; Ji M.; Huang, W. Redesign of ultrasensitive and robust RecA gene circuit to sense DNA damage. Microbial Biotechnology, 2021
17. Jiang B, Song Y, Liu Z, Huang WE, Li G, Deng S, Xing Y, Zhang D. Whole-cell bioreporters for evaluating petroleum hydrocarbon contamination. Critical Reviews in Environmental Science and Technology 2020: 1-51.
18. Song Y, et al. Overproduction of proteorhodopsin enhances long-term viability of Escherichia coli. Applied and environmental microbiology. 2020. 86(1）02087-19
19. Song Y, Cartron M, Jackson P, Davison P, Dickman M, Zhu D, ... & Hunter C. (2019). Proteorhodopsin overproduction enhances the long-term viability of Escherichia coli. Applied and Environmental Microbiology, 86(1), e02087-19.
20. Jiang B, Zhang N, Xing Y, Lian L, Chen Y, Zhang D, ... & Song Y. (2019). Microbial degradation of organophosphorus pesticides: novel degraders, kinetics, functional genes, and genotoxicity assessment. Environmental Science and Pollution Research, 26, 21668-21681.
21. Song Y, Rampley C, Chen X, Du F, Thompson I, & Huang W. (2019). Application of Bacterial Whole-Cell Biosensors in Health. In G. Thouand (Ed.), Handbook of Cell Biosensors (pp. 1-17). Cham: Springer International Publishing.
22. Zhang Q, Song Y, et al. Monitoring Cr toxicity and remediation process – combining a whole-cell bioreporter and Cr isotope techniques, Water Research, 2019. 153:295-303
23. Liang B, Gao Y, Xu J, Song Y, Xuan L, Shi T, Chen Z. Raman profiling of embryo culture medium to identify aneuploid and euploid embryos. Fertility and Sterility, 2019. 111(4), 753-762.e751.
24. Jing, X, Gou H, Gong Y, Su X, Xu L, Ji Y, Song Y, Thompson, L Xu J and Huang W Raman-activated cell sorting and metagenomic sequencing revealing carbon-fixing bacteria in the ocean. Environ Microbiol. 2018( doi: 10.1111/1462-2920.14268.)
25. Cui Z, Luan X, Jiang H, Li Q, Xu G, Sun C, Zheng L, Song Y, Davison P and Huang W, Application of a bacterial whole cell biosensor for the rapid detection of cytotoxicity in heavy metal contaminated seawater. Chemosphere 2018. 200: 322-329.
26. Yuan X, Song Y, Song Y, et al., Effect of laser irradiation on cell function and its implications in Raman spectroscopy. Applied and Environmental Microbiology, 2018.(doi:10.1128/AEM.02508-17)
27. Song Y., Kaster A, Vollmers J, Song Y, Davison P, Frentrup M, ... & Huang W. (2017). Single‐cell genomics based on Raman sorting reveals novel carotenoid‐containing bacteria in the Red Sea. Microbial Biotechnology, 10(1), 125-137.
28. Xu J, Zhu D, Ibrahim A, Allen C, Gibson C, Fowler P, Song Y & Huang W. (2017). Raman deuterium isotope probing reveals microbial metabolism at the single-cell level. Analytical chemistry, 89(24), 13305-13312.
29. Song Y, Kaster AK, Vollmers J, Song Y, Davison PA, Frentrup M, et al. Single-cell genomics based on Raman sorting reveals novel carotenoid-containing bacteria in the Red Sea. Microb Biotechnol. 2017;10(1):125-37
30. Song Y, et al., Raman-Deuterium Isotope Probing for in-situ identification of antimicrobial resistant bacteria in Thames River. Scientific Reports, 2017. 7(1): p. 16648