生物医药

1． 干细胞／类脑器官治疗神经系统重大疾病及其机制研究。
2． 类器官和微生理系统构建及应用。

1. Non-monotonic response of macrophages to mechanical stretch impacts skin wound healing. Cell Mol Biol Lett. 2025 Jul 15;30(1):82. doi: 10.1186/s11658-025-00764-0. PMID: 40665211.
2. Single-cell Raman spectroscopy as a novel platform for unveiling the heterogeneity of mesenchymal stem cells. Talanta. 2025 Mar 12;292:127933. doi: 10.1016/j.talanta. 2025.127933. PMID: 40081243.
3. Activation of angiopoietin-1 signaling with engineering mesenchymal stem cells promoted efficient angiogenesis in diabetic wound healing. Stem Cell Res Ther. 2025 Feb 21;16(1):75. doi: 10.1186/s13287-025-04207-7. PMID: 39985096.
4. Mesenchymal Stem Cells Restore Endothelial Integrity and Alleviate Emotional Impairments in a Diabetic Mouse Model via Inhibition of MMP-9 Activity. Int J Mol Sci. 2025 Apr 3;26(7):3355. doi: 10.3390/ijms26073355. PMID: 40244194.
5. Controlled release of mesenchymal stem cell-derived nanovesicles through glucose- and reactive oxygen species-responsive hydrogels accelerates diabetic wound healing. Journal of Controlled Release, 2024 Dec;376:985-998.
6. Neural Progenitor Cell-Mediated Magnetic Nanoparticles for Magnetic Resonance Imaging and Photothermal Therapy of Glioma. ACS Appl Bio Mater. 2024 Jul 15;7(7):4553-4561. doi: 10.1021/acsabm.4c00414.
7. Adipose-Derived Stem-Cell-Membrane-Coated PLGA-PEI Nanoparticles Promote Wound Healing via Efficient Delivery of miR-21. Pharmaceutics. 2024 Aug 23;16(9):1113.
8. High-Voltage Electrostatic Field Hydrogel Microsphere 3D Culture System Improves Viability and Liver-like Properties of HepG2 Cells. Int J Mol Sci. 2024 Jan 16;25(2):1081. doi: 10.3390/ijms25021081.
9. The composite biomatrix SC/CM improved the therapeutic effects of xenogeneic MSC on wound healing in immune-competent mice via immune niche reprogramming. J. Mater Sci., 2024,59, 15514–15528.
10. Cerebral-Organoid-Derived Exosomes Alleviate Oxidative Stress and Promote LMX1A-Dependent Dopaminergic Differentiation. Int J Mol Sci. 2023 Jul 4;24(13):11048. doi: 10.3390/ijms241311048.
11. Metformin coordinates with mesenchymal cells to promote VEGF-mediated angiogenesis in diabetic wound healing through Akt/mTOR activation. Metabolism. 2023 Mar;140:155398. doi: 10.1016/j.metabol.2023.155398.
12. Development of a portable reflectance confocal microscope and its application in the noninvasive in vivo evaluation of mesenchymal stem cell-promoted cutaneous wound healing. Bio-design and manufacturing, 2023；6：268–283.
13. In Situ-Formed Fibrin Hydrogel Scaffold Loaded With Human Umbilical Cord Mesenchymal Stem Cells Promotes Skin Wound Healing. Cell Transplant. 2023 32: 9636897231156215.
14. Multimodal Magnetic Resonance and Fluorescence Imaging of the Induced Pluripotent Stem Cell Transplantation in the Brain. Molecular Biology, 2022;56(3):500-502.
15. Novel pneumatically assisted atomization device for living cell delivery and application of sprayed mesenchymal stem cells in skin regeneration. Bio- design and manufacturing, 2022; 5, 220–232.
16. The Different Molecular Code in Generation of Dopaminergic Neurons from Astrocytes and Mesenchymal Stem Cells. Int J Mol Sci. 2021; 22(22): 12141
17. Matrigel/umbilical cord-derived mesenchymal stem cells promote granulosa cell proliferation and ovarian vascularization in a mouse model of premature ovarian failure. Stem Cells and Development. 2021; 30(15):782-796.
18. Synthesis of SPIO nanoparticles and the subsequent applications in stem cell labeling for Parkinson's disease. Nanoscale Res Lett, 2021, 16:107.
19. Targeting epidermal growth factor-overexpressing triple-negative breast cancer by natural killer cells expressing a specific chimeric antigen receptor. Cell Proliferation, 2020 Aug;53(8):e12858.
20. Neonatal DEX exposure leads to hyperanxious and depressive-like behaviors as well as a persistent reduction BDNF expression in developmental stages. Biochemical and Biophysical Research Communications, 2020, Vol.527(1): 311-316.
21. Protein Kinase D3 promotes the cell proliferation by activating the ERK1/c‐MYC axis in breast cancer. J Cell Mol Med.，2020;24:2135–2144.

1． 国家重点研发计划“干细胞研究与器官修复”专项（首席）。
2． 国家自然基金面上项目（项目负责人）。
3． 姑苏重大创新团队项目（领军人才）。
4． 中国科学院战略先导计划（项目骨干）。
5． 江苏省基础研究重点项目（项目骨干）。