生物医药

开发合成生物学技术并应用于构建高效微生物细胞工厂，生产有机酸、氨基酸、材料化学品、酸性多糖和植物天然产物

[1] Guo L, Diao WW, Gao C, Hu GP, Ding Q, Ye C, Chen XL, Liu J, Liu LM*. Engineering Escherichia coli lifespan for enhancing chemical production [J]. Nature Catalysis, 2020, 3:307-318.
[2] Diao W, Guo L, Ding Q, Gao C, Hu G, Chen X, Li Y, Zhang L, Chen W, Chen J, Liu LM*. Reprogramming microbial populations using a programmed lysis system to improve chemical production[J]. Nature Communications, 2021, 12(1): 6886.
[3] Liu H, Zhou P, Qi M, Guo L, Gao C, Hu G, Song W, Wu J, Chen X, Chen J, Chen W, Liu LM*. Enhancing biofuels production by engineering the actin cytoskeleton in Saccharomyces cerevisiae . Nature Communications, 2022, 13: 1886.
[4] Cong Gao, Jianshen Hou, Peng Xu, Liang Guo, Xiulai Chen, Guipeng Hu, Chao Ye, Harley Edwards, Jian Chen, Wei Chen & Liu LM*. Programmable biomolecular switches for rewiring flux in Escherichia coli[J]. Nature Communications, 2019, 10:3751-3763.
[5] Pei Zhou, Hui Liu, Xin Meng, Huiyun Zuo, Mengya Qi, Liang Guo, Cong Gao, Wei Song, Jing Wu, Xiulai Chen, Wei Chen, Liu LM*. Engineered artificial membraneless organelles in Saccharomyces cerevisiae to enhance chemical production[J]. Angewandte Chemie International Edition, 2023, 62(14): e202215778.
[6] Dengke Gao, Wei Song, Jing Wu, Liang Guo, Cong Gao, Jia Liu, Xiulai Chen, Liu LM*. Efficient production of l-homophenylalanine by enzymatic–chemical cascade catalysis[J]. Angewandte Chemie International Edition, 2022, 61(36): e202207077.
[7] Ming Wang, Haomiao Wang, Cong Gao, Wanqing Wei, Jia Liu, Xiulai Chen, Guipeng Hu, Wei Song, Jing Wu, Fan Zhang, Liming Liu*. Efficient production of protocatechuic acid using systems engineering of Escherichia coli[J]. Metabolic Engineering, 2024, 82: 134-146.
[8] Li Z, Gao C, Ye C, Guo L, Liu J, Chen X, Song W, Wu J, Liu LM*. Systems engineering of Escherichia coli for high-level shikimate production [J]. Metabolic Engineering, 2023, 75: 1-11.
[9] Guo L, Ding S, Liu Y, Gao C, Hu G, Song W, Liu J, Chen X, Liu LM*. Enhancing tryptophan production by balancing precursors in Escherichia coli. Biotechnology and Bioengineering, 2022, 119:983-993.
[10] Xiulai Chen, Cong Gao, Liang Guo, Guipeng Hu, Qiuling Luo, Jia Liu, Jian Chen, Jens Nielsen, Liming Liu*. DCEO biotechnology: tools to design, construct, evaluate, and optimize the metabolic pathway for biosynthesis of chemicals[J]. Chemical Reviews, 2018, 118: 64-72.

[1] 一株产L-苹果酸的米曲霉及其应用.  ZL201610846137.8
[2] 一种高效生产琥珀酸的重组大肠杆菌及其构建方法. CN202011185169.0
[3] 高效生产戊二酸的重组大肠杆菌及其构建方法与应用. CN202111433195.5
[4] 一种生产己二酸的重组菌、构建方法和应用. CN202111423759.7
[5] 一株产L-赖氨酸的大肠杆菌及其应用. CN201911370748.X
[6] 一株产L-缬氨酸的黄色短杆菌及其应用. CN201910349690.4
[7] 一株生产L-色氨酸的重组大肠杆菌及其应用. CN202111434507.4
[8] 一株产聚赖氨酸的白色链霉菌及其应用. CN202010698081.2
[9] 一种高效生产L-高苯丙氨酸的方法. ZL 202210720068.1
[10] 一种酶法催化高产α-酮异己酸的方法. CN201810377203.0
[11] 一种转化L-苏氨酸生产L-2-氨基丁酸的重组菌的构建. CN201811119484.6
[12] 一种多酶级联生产(R/S)-羟基蛋氨酸的方法. CN201911128392.9
[13] 一种生产α-酮戊二酸的双酶共表达菌株的构建方法.CN201610365301.3
[14] 一种高效生产果糖软骨素的重组大肠杆菌及其构建方法.CN201710616371.6
[15] 一种生产莽草酸的重组菌及其构建方法和应用.CN202111425348.1

[1] 国家重点研发计划(2018YFA0901400；2020YFA0908500). 在研，主持
[2] 国家自然科学基金重点项目(22038005). 在研，主持
[3] 国家自然科学基金面上项目(32070124). 在研，主持
[4] 江苏省前沿引领技术基础研究专项(BK20212013). 在研，主持
[5] 江苏省农业创新专项科研基金(CX(22)1012). 在研，主持

技术咨询