生物医药

酿造食品微生物开发与应用，新型工业菌株的基因表达调控元件开发

Yanting Duan, Xiaojuan Zhang*, Weiji Zhai, Jinpeng Zhang, Xiaomei Zhang, Guoqiang Xu, Hui Li, Zhaohong Deng, Jinsong Shi, and Zhenghong Xu*, Deciphering the Rules of Ribosome Binding Site Differentiation in Context Dependence. ACS Synthetic Biology. 2022, 11(8): 2726–2740.
Weiji Zhai, Yanting Duan, Xiaomei Zhang, Guoqiang Xu, Hui Li, Jinsong Shi, Zhenghong Xu, Xiaojuan Zhang*, Sequence and thermodynamic characteristics of terminators revealed by FlowSeq and the discrimination of terminators strength, Synthetic and Systems Biotechnology, 2022, 4(7): 1046-1055.
Yanting Duan, Weiji Zhai, Weijia Liu, Xiaomei Zhang, Jinsong Shi, Xiaojuan Zhang*, Zhenghong Xu*. Fine tuning multi-gene cluster via well characterized gene expression regulatory elements: case study of arginine-synthesis pathway in C. glutamicum, ACS Synthetic Biology. 2021 10 (1), 38-48.
Xiao-Juan Zhang, Lian-Jun Meng, Zhen-Ming Lu, Li-Juan Chai, Song-Tao Wang, Jin-Song Shi, Cai-Hong Shen, Zheng-Hong Xu*., Identification of age-markers based on profiling of Baijiu volatiles over a two-year maturation period: Case study of Lu-flavor Baijiu. LWT- Food Science and Technology, 2021, 141(1):110913.
Shanshan Wang, Xiaojuan Zhang*, Heng Li, Yilin Ren, Yan Geng, Zhenming Lu, Jinsong Shi, Zhenghong Xu*. Similarities and differences of oligo/poly-saccharides’ impact on human fecal microbiota identified by in vitro fermentation. Applied Microbiology Biotechnology. 2021,105(19):7475-7486.
Ming-Ye Peng, Xiao-Juan Zhang*, Ting Huang, Xiao-Zhong Zhong, Li-Juan Chai, Zhen-Ming Lu, Jin-Song Shi, Zheng-Hong Xu*, Komagataeibacter europaeus improves community stability and function in solid-state cereal vinegar fermentation ecosystem: Non-abundant species plays important role, Food Research International, 2021, 150, Part B, 110815.
Zhiyun He, Yanting Duan, Weiji Zhai, Xiaomei Zhang, Jinsong Shi, Xiaojuan Zhang*. Zhenghong Xu. (2020). Evaluating terminator strength based on differentiating effects on transcription and translation. ChemBioChem, 2020‏，21(4):2067-2072.
Xiaojuan Zhang, Zhixuan Yao, Yanting Duan, Xiaomei Zhang, Jinsong Shi, Zhenghong Xu. Investigation of specific interactions between T7 promoter and T7 RNA polymerase by force spectroscopy using atomic force microscope. Biochemical Journal, 2018, 475(1): 319-328.
Xiaojuan Zhang, Yuying Liu, Hui Li, Lili Su, Longfei Zhou, Jun Peng, Rui Shen, Yi Zhang, Jinsong Shi, Zhenghong Xu, Microemulsion system for Colletotrichum lini ST-1 biotransformation of dehydroepiandrosterone to 7α,15α-diOH-DHEA, Biochemical Engineering Journal, 2018, 131, 77-83.
Hongshan Wang, Xiaojuan Zhang, Shanshan Wang, Heng Li, Zhenming Lu, Jinsong Shia, Zhenghong Xu. Mannan-oligosaccharide modulates the obesity and gut microbiota in high fat diet mice. Food & Function, 2018,9, 3916-3929.

（1）国家自然科学基金面上基金，32171421，基于细菌5'UTR构效解析的RBS稳定器理性设计与构建，2022-2025，主持。
（2）国家自然科学基金青年基金，31600044，基于AFM力谱与SPR技术的启动子强度高效表征策略的研究，2017-2019，主持。
（3）江苏省自然科学基金，BK20150151，基于RNA聚合酶与启动子交互作用的谷氨酸棒杆菌转录强度分析，2015-2018，主持。
（4）十三五国家重点研发计划“现代食品加工及粮食收储运技术与装备专项”项目“传统发酵食品制造关键技术与装备开发”（2018YFD0400400）骨干。
（5）近五年主持横向项目多项，到账经费200余万元。