生物医药

微生物活性物质挖掘和药理学机制

1. K. Yu, Q. Li, X. Sun, J. Lv, C. Miao, J. Yang, S. Wang, Z. Fu, Y. Sun, H. Zhang, Z. Zhang, Z. Yao*, Wang Q*. Bacterial indole-3-lactic acid affects epithelium-macrophage crosstalk to regulate intestinal homeostasis. Proc Natl Acad Sci U S A, 2023,120(45):e2309032120.
2. C. Miao, Y. Zhang, M. Yu, Y. Wei, C. Dong, G. Pei, Y. Xiao, J. Yang, Z. Yao, Wang Q*. HSPA8 regulates anti-bacterial autophagy through liquid-liquid phase separation. Autophagy, 2023,19(10):2702-2718.
3. C. Miao#, M. Yu#, G. Pei, Z. Ma, L. Zhang, J. Yang, J. Lv, Z. Zhang, E. Keller, Z. Yao*, Wang Q*, An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli. Nature Communications, 2021, 12:2587.
4. J. Yang, G. Pei, X. Sun, Y. Xiao, C. Miao, L. Zhou, B. Wang, L. Yang, M. Yu, Z. Zhang, E. Keller, Z. Yao, Wang Q*, RhoB Affects Colitis through Modulating Cell Signaling and Intestinal Microbiome. Microbiome, 2022, 10:149.
5. Q. Tang, G. Fan, X. Peng, X. Sun, X. Kong, L. Zhang, C. Zhang, Y. Liu, J. Yang, K. Yu, C. Miao, Z. Yao, L. Li*, Z. Zhang*, Wang Q*, Gut bacterial L-lysine induces metabolic and epigenetic reprogramming to drive dendritic cell tolerance. Cell Reports, 2025, 44:115125.
6. Q. Li, X. Sun, K. Yu, J. Lv, C. Miao, J. Yang, S. Wang, Z. Fu, Y. Sun, H. Zhang, Z. Zhang, E. Keller, Z. Yao*, Wang Q*, Enterobacter ludwigii protects DSS-induced colitis through choline-mediated immune tolerance. Cell Reports, 2022, 40:111308.
7. J. Yang#, Y. Xiao#, N. Zhao, G. Pei, Y. Sun, X. Sun, K. Yu, C. Miao, R. Liu, J. Lv, H. Chu, L. Zhou, B. Wang, Z. Yao*, Wang Q*, PIM1-HDAC2 axis modulates intestinal homeostasis through epigenetic modification. Acta Pharmaceutica Sinica B, 2024, 14(7):3049-3067.
8. C. Miao#, Y. Zhang#, G. Liu, J. Yang, K. Yu, J. Lv, R. Liu, Z. Yao, Y. Niu, X. Wang, Wang Q*, Multi-step strategies for synergistic treatment of urinary tract infections based on D-xylose-decorated antimicrobial peptide carbon dots. Biomaterials, 2024. 308: p. 122547.
9. X. Li#, G. Pei#, L. Zhang, Y. Cao, J. Wang, L. Yu, W. Dianjun, S. Gao, Z. S. Zhang, Z. Yao, Wang Q*, Compounds targeting YadC of uropathogenic Escherichia coli and its host receptor annexin A2 decrease bacterial colonization in bladder. EBioMedicine, 2019, 50: 23-33.
10. Guo Y#, Zhang Z#, Wei H, Wang J, Lv J, Zhang K, Keller ET, Yao Z*, Wang Q*. Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42-PAK1 axis. Journal of Pathology, 2017. 243:208-219.
11. Sun, X#, J. Yang#, X. Deng#, Y. Wei, C. Wang, Y. Guo, H. Yang, L. Yang, C. Miao, J. Lv, Y. Xiao, H. Zhang, Z. Yao*, and Wang Q*, Interactions of Bacterial Toxin CNF1 and Host JAK1/2 Driven by Liquid-Liquid Phase Separation Enhance Macrophage Polarization. mBio, 2022, 13(4): e0114722.
12. C. Wang#, Q. Li#, J. Lv, X. Sun, Y. Cao, K. Yu, C. Miao, Z. S. Zhang, Z. Yao*, Wang Q*, Alpha-hemolysin of uropathogenic Escherichia coli induces GM-CSF-mediated acute kidney injury. Mucosal Immunology, 2020. 13: 22-33.

1. 一种基于菌毛多样性的尿路感染大肠杆菌的分型方法。王荃。专利号：ZL201510022361.0。2017年2月22日授权。技术转让。
2. 靶向菌毛黏附素YadC的宿主受体ANXA2用于改善急性下尿路感染。王荃，李晓，裴庚。专利号：ZL201910957083.6。2022年5月24日授权。
3. 一株大肠埃希氏菌、菌剂及其在制备预防和/或治疗炎症性肠病中的应用。王荃，姚智，于开源。申请号：202311127734.1。
4. 赖氨酸在制备治疗多发性硬化症药物中的应用。王荃，唐强。申请号：202410278344.2。
5. D-木糖化抗菌肽碳点及制备方法和应用。王荃，王晓娟，姚智，苗春晖。申请号：202310897400.6
6. 一株嗜粘蛋白阿克曼氏菌TMU及其相关生物材料和应用。王荃，姚智，杨柳。申请号：202411282534.8
7. 对大肠杆菌O134型的O-抗原特异的核苷酸。王磊，王荃，冯露。 专利号：ZL200410094100.1。2007年5月16日授权。
8. 变形杆菌多种血清型菌株特异性引物及多重PCR检测方法。王磊，王荃，彭志勇，冯露。专利号：ZL 201310115652.5。2014年11月26日授权。
9. 一种在革兰氏阳性菌中合成的CDP-2-甘油及其制备方法。王磊，徐艳丽，王荃，冯露。专利号 ZL 201010141807.9。2014年2月5日授权。

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