论文著作：
1. Hu X#, Jiang H#, Bai W, Liu X, Miao Q, Wang L, Jin J, Cui A, Liu R*, Li Z*. Synthesis, characterization, and targeted chemotherapy of SCT200-linker-monomethyl auristatin E conjugates. Eur J Med Chem. 2021; DOI: 10.1016/j.ejmech.2021.113297.
2. Jiang H, Liu J, Guo S, Zeng L, Ashraf GM, Barreto GE, Zhang J, Wang L, Li Z*, Liu R*. miR-23b-3p rescues cognition by reducing Tau phosphorylation and apoptosis via GSK-3β signaling in Alzheimer's disease. Brain Behav Immun. 2021, in press.
3. Zeng L, Jiang HL, Ashraf GM, Li ZR*, Liu R*. MicroRNA and messenger RNA profiling of cerebral cortex in a transgenic mouse model of Alzheimer’s disease by RNA sequencing. Neural Regen Res. 2021;16(10):2099-2108.
4. Jiang H†, Zeng L†, Dong X, Guo S, Xing J, Li Z*, Liu R*. Tilianin Extracted From Dracocephalum moldavica L. Induces Intrinsic Apoptosis and Drives Inflammatory Microenvironment Response on Pharyngeal Squamous Carcinoma Cells via Regulating TLR4 Signaling Pathways. Front Pharmacol. 2020;11:205.
5. Tencheva A†, Liu R†, Volkova TV, Chayrov R, Mitrev Y, Štícha M, Li Y, Jiang H, Li Z, Stankova I*, Perlovich GL*. Synthetic analogues of memantine as neuroprotective and influenza viral inhibitors: in vitro and physicochemical studies. Amino Acids. 2020;52(11-12):1559-1580.
6. Wang L†, Liu J†, Wang Q, Jiang H, Zeng L, Li Z*, Liu R*. MicroRNA-200a-3p mediates neuroprotection in Alzheimer-related deficits and attenuates amyloid-beta overproduction and tau hyperphosphorylation via coregulating BACE1 and PRKACB. Front Pharmacol. 2019;10:806.
7. Yuan F#, Liu R#, Hu M, Rong X, Bai L, Xu L, Mao Y, Hamulati H, Sun Y*, He J*. JAX2, an ethanol extract of Hyssopus cuspidatus Boriss, can prevent bronchial asthma by inhibiting MAPK/NF-κB inflammatory signaling. Phytomedicine. 2019;57:305-314.
8. Wang Q, Jiang H, Wang L, Yi H, Li Z*, Liu R*. Vitegnoside Mitigates Neuronal Injury, Mitochondrial Apoptosis, and Inflammation in an Alzheimer's Disease Cell Model via the p38 MAPK/JNK Pathway. J Alzheimers Dis. 2019;72(1):199-214.
9. Wang L†, Fang J†, Jiang H, Wang Q, Xue S, Li Z*, Liu R*. 7-pyrrolidinethoxy-4'-methoxyisoflavone prevents amyloid β–induced injury by regulating histamine H3 receptor-mediated cAMP/CREB and AKT/GSK3β pathways. Front Neurosci. 2019;13:334.
10. Liu QS, Deng R, Fan Y, Li K, Meng F, Li X*, Liu R*. Low dose of caffeine enhances the efficacy of antidepressants in major depressive disorder and the underlying neural substrates. Mol Nutr Food Res. 2017;61(8):1600910.
发明专利：
[1] Liu, Rui; Li, Zhuorong; Jiang, Hailun; Zeng, Li; Wang, Linlin；Use of miRNA 148 cluster as Marker for Diagnosing and/or Treating Cognitive Impairment-Associated Diseases: Australia, 2021101144.
[2] LIU Rui; LI Zhuorong; JIANG Hailun; ZENG Li; ZHANG Junxia; miRNA MARKER FOR DIAGNOSIS AND TREATMENT OF ALZHEIMER’S DISEASE: Australia, 2020103707.
[3] LIU Rui; LI Zhuorong; ZENG Li; JIANG Hailun; ZHANG Junxia. USE OF miRNA30a CLUSTER AS DIAGNOSTIC MARKER AND THERAPEUTIC TARGET FOR ALZHEIMER'S DISEASE: Australia, 2020103933.
[4] Ivanka Stankova; Radoslav Chayrov; Trayana Nedeva; Boris Shivachev; Hristina Sbirkova-Dimitrova; Yavor Mitrev; Rui Liu; Zhuorong Li; Hailun Jiang. NMDA-рецепторен антагонист с антимикробна активност: Bulgaria, BG/P/2020113103.
[5] 刘睿；李卓荣；姜海伦；曾利；等. 一种用于阿尔茨海默病诊断和/或治疗的miRNA标志物：中国，201911078320.8.
[6] 刘睿；李卓荣；姜海伦；王琳琳；曾利. miRNA 200簇作为阿尔茨海默病诊断和/或治疗的标志物的应用：中国, 202010112719.X.
[7] 刘睿；李卓荣；曾利；姜海伦；张俊霞. miRNA30簇作为阿尔茨海默病诊断标志物的应用：中国，202010269842.2.
[8] 刘睿；李卓荣；姜海伦；曾利；王琳琳. miRNA 148簇作为诊断和/或治疗认知障碍相关疾病标志物的应用：中国，202010738200.2.
刘睿
北京市
研究领域：
生物医药
研究方向：
神经药理学与新药研发
所在单位：
中国医学科学院北京协和医学院
