生物医药

抗菌药物的发现和作用机制，细菌疫苗的研究

1. Synthesis and antibacterial evaluation against resistant Gram-negative bacteria of monobactams bearing various substituents on oxime residue. Li ZW*, Lu X*, Wang YX, Hu XX, Fu HG, Gao LM, You XF, Tang S, Song DQ. Bioorg Chem. 2020 Jan;94:103487.
2. Synthesis and biological evaluation of 7-substituted cycloberberine derivatives as potent antibacterial agents against MRSA. Yang YS*, Lu X*, Zeng QX, Pang J, Fan TY, You XF, Tang S, Wang YX, Song DQ. Eur J Med Chem. 2019 Apr 15;168:283-292.
3. Synthesis and antibacterial evaluation of sulbactam derivatives against Acinetobacter baumannii. Yang YS, Tang S, Liu ZD, Wang YX, Pang J, You XF, Song DQ, Li YH*, Lu X*. Pharmazie. 2018; 73 (8): 433-437
4. A Poly-N-acetylglucosamine-Shiga toxin broad-spectrum conjugate vaccine for Shiga toxin-producing Escherichia coli. Lu X*, Skurnik D*, Pozzi C, Roux D, Cywes-Bentley C, Ritchie JM, Munera D, Gening ML, Tsvetkov YE, Nifantiev NE, Waldor MK, Pier GB. mBio. 2014 Mar 25;5(2):e00974-14.
5. In vitro activity of sodium new houttuyfonate alone and in combination with oxacillin or netilmicin against methicillin-resistant Staphylococcus aureus. Lu X*, Yang X*, Li X, Lu Y, Ren Z, Zhao L, Hu X, Jiang J, You X. PLoS One. 2013 Jul 2;8(7):e68053.
6. Extended-spectrum antibodies protective against carbapenemase-producing Enterobacteriaceae. Skurnik D, Roux D, Pons S, Guillard T, Lu X, Cywes-Bentley C, Pier GB. J Antimicrob Chemother. 2016 Apr;71(4):927-35.
7. Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. An D, Oh SF, Olszak T, Neves JF, Avci FY, Erturk-Hasdemir D, Lu X, Zeissig S, Blumberg RS, Kasper DL. Cell. 2014 Jan 16;156(1-2):123-33.
8. Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing. Skurnik D, Roux D, Cattoir V, Danilchanka O, Lu X, Yoder-Himes DR, Han K, Guillard T, Jiang D, Gaultier C, Guerin F, Aschard H, Leclercq R, Mekalanos JJ, Lory S, Pier GB. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20747-52.
9. Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, Deoliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T, Rey A, Perrin C, Fichorova RN, Kayatani AK, Maira-Litràn T, Gening ML, Tsvetkov YE, Nifantiev NE, Bakaletz LO, Pelton SI, Golenbock DT, Pier GB. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2209-18.
10. In vivo antibacterial activity of MRX-I, a new oxazolidinone. Li CR, Zhai QQ, Wang XK, Hu XX, Li GQ, Zhang WX, Pang J, Lu X, Yuan H, Gordeev MF, Chen LT, Yang XY, You XF. Antimicrob Agents Chemother. 2014;58(4):2418-21.
11. 卢曦，任志涛，李聪然，胡辛欣，聂彤颖，黄青山，陆海荣，李雪， 李国庆，蒋建东，游雪甫，杨信怡*，重组溶葡萄球菌酶体外诱导的金黄色葡萄球菌耐药株生物学特征，中国感染与化疗杂志，2015年03期
12. 卢曦，李聪然，庞晶，胡辛欣，聂彤颖，杨信怡，李雪，李国庆，王秀坤，游雪甫*，新碳青霉烯类抗生素百纳培南的小鼠泌尿道感染药效学研究，中国医药生物技术，2015年02期

1. 瑞香素在抗幽门螺杆菌中的应用，发明人：游雪甫，王根柱，李聪然，杨信怡，王秀坤，熊雁琼，庞晶，卢曦，胡辛欣，聂彤颖，李雪，卢芸；专利号：CN201711071301.3，授权时间：2020-02-18
2. Myrtucommulone R及其在制备抗菌药物中的应用，发明人：叶文才，王磊，杨信怡，卢曦，游雪甫，陈明；专利号：ZL201710238171.1 授权时间：2019-04-05
3. 环丙烯酮类化合物作为抗菌剂的用途，发明人：游雪甫，张友文，胡辛欣，李雪，王秀坤，董立民，杨信怡，李聪然，李国庆，庞晶，卢曦，卢芸，聂彤颖；专利号：CN201811539050.1 申请时间：2018-12-14
4. 蟛蜞菊内酯在制备用于治疗特发性肺纤维化药物中的应用，发明人：杨信怡，游雪甫，董文婷，王秀坤，李聪然，卢曦，庞晶，胡辛欣，聂彤颖，李国庆，李雪；专利号：CN201710444475.3 申请时间：2017-9-13

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