生物医药

微生物来源天然产物生物合成机制及合成生物学研究

1. Yuanyuan Shi, Zhibo Jiang, Xiaowen Hu, Xiaomin Hu, Renjie Gu, Bingya Jiang, Lijie Zuo, Xingxing Li, Hongmin Sun, Cong Zhang, Lifei Wang, Linzhuan Wu* and Bin Hong*. The cytochrome P450 catalyzing C-S bond formation in S-heterocyclization of chuangxinmycin biosynthesis. Angewandte Chemie International Edition. 2021, 60, 15399-15404. (IF: 15.336)
2. Yuanyuan Shi, Renjie Gu, Yihong Li, Xinwei Wang, Weicong Ren, Xingxing Li, Lifei Wang, Yunying Xie* and Bin Hong*. Exploring novel herbicidin analogues by transcriptional regulator overexpression and MS/MS molecular networking. Microbial Cell Factories. 2019, 18:175. (IF: 4.402)
3. Yuanyuan Shi#, Xinwei Wang#, Ning He, Yunying Xie*, Bin Hong*. Rescrutiny of the sansanmycin biosynthetic gene cluster leads to the discovery of a novel sansanmycin analogue with more potency against Mycobacterium tuberculosis. Journal of antibiotics. 2019,72:769-774. (IF: 2.446)
4. Yuanyuan Shi#, Zhibo Jiang#, Xingxing Li, Lijie Zuo, Xuan Lei, Liyan Yu, Linzhuan Wu*, Jiandong Jiang*, Bin Hong*. Biosynthesis of antibiotic chuangxinmycin from Actinoplanes tsinanensis. Acta Pharmaceutica Sinica B. 2018; 8(2): 283-294. (IF: 6.014)
5. Yuanyuan Shi, Zhibo Jiang, Xuan Lei, Ningning Zhang, Qiang Cai, Qinglian Li, Lifei Wang, Shuyi Si, Yunying Xie*, Bin Hong*. Improving the N-terminal diversity of sansanmycin through mutasynthesis. Microbial Cell Factories. 2016, 15:77. (IF: 3.744)

1. 洪斌，侍媛媛，武临专，蒋建东，江志波，李星星，左利杰，雷璇。一组生物合成创新霉素或开环创新霉素的基因簇。中国发明专利，2020年7月24日授权，ZL201710584431.0[P]。
2. 洪斌，解云英，侍媛媛，江志波，雷璇，张宁宁，蔡强，李青连，王丽非，司书毅。利用突变合成获得SANSANMYCIN结构类似物的方法。中国发明专利，2020年2月11日授权，ZL201610219358.2[P]。
3. 洪斌，解云英，侍媛媛，谷仁杰，李怡宏，王新位，任卫聪，李星星，王丽非，张丛。Herbicidin生物合成基因簇及其应用。中国发明专利，2021年2月9日授权，ZL201910471680.8[P]。
4. 解云英，陈汝贤，许鸿章，洪斌，何宁，侍媛媛。前体定向生物合成的尿苷肽类抗生素及其用途。中国发明专利，2019年10月17日授权，ZL201611142063.6 [P] 。

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