生物医药

微生物来源天然产物生物合成研究；肠道微生物功能研究。

1.Li YH, Ding XT, Du Y, Li YH, Ren WC,Lu Y, Shi YY, Sun HM, Wang LF, Li YH, Li XX*, Xie YY*, and Hong B*. Genome-Directed Discovery of Bicyclic Cinnamoyl-Containing Nonribosomal Peptides with Anticoronaviral Activity from Streptomyces griseus. Org. Lett. 2023, 25(26): 4874-4879.
2.Li XX#, Fu J#, Li YH, Liu JC, Gao RM, Shi YY, Li YH, Sun HM, Wang LF, Li YH, Jiang BY*, Wu LZ*, Hong B*. Cytochrome P450 Monooxygenase for Catalyzing C-42 Hydroxylation of the Glycine-Derived Fragment in Hangtaimycin Biosynthesis. Org. Lett. 2022, 24(6), 1388-1393.
3.Sun HM#, Li XX#, Chen MH#, Zhong M, Li YH, Wang K, Du Y, Zhen X, Gao RM, Wu YX, Shi YY, Yu LY, Che YS, Li YH*, Jiang JD*, Hong B*, Si SY*. Multi-Omics-Guided Discovery of Omicsynins Produced by Streptomyces sp. 1647: Pseudo-Tetrapeptides Active against Influenza a Viruses and Coronavirus HCoV-229E. Engineering, 2022, 16: 176-186.
4.Li XX#, Su CY#, Jiang ZB, Yang YX, Zhang Y, Yang MX, Zhang XM, Du Y, Zhang J, Wang L*, Jiang JD*, Hong B*. Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome. NPJ Biofilms Microbiomes, 2021, 7(1): 36.
5.Li XX#, Zhang C#, Zhao Y, Lei X, Jiang ZB, Zhang XX, Zheng ZH, Si SY*, Wang LF*, Hong B*. Comparative Genomics and Transcriptomics Analyses Provide Insights into the High Yield and Regulatory Mechanism of Norvancomycin Biosynthesis in Amycolatopsis orientalis NCPC 2-48. Microb Cell Fact, 2021, 20(1):28.
6.Li XX#, Ren WC#, Li YH, Shi YY, Sun HM, Wang LF, Wu LZ, Xie YY, Du Y, Jiang ZB*, Hong B*. Production of chain-extended cinnamoyl compounds by overexpressing two adjacent cluster-situated LuxR regulators in Streptomyces globisporus C-1027. Front Microbiol, 2022, 13, 931180.
7.Li XX#, Wu S#, Du Y, Yang L, Li YH *, Hong B *. Entecavir Therapy Reverses Gut Microbiota Dysbiosis Induced by Hepatitis B Virus Infection in a Mouse Model. Int J Antimicrob Agents, 2020, 56(1):106000.
8.Du Y#, Li XX#, Su CY, Wang L, Jiang JD*, Hong B*. The human gut microbiome - a new and exciting avenue in cardiovascular drug discovery. Expert Opin Drug Discov, 2019, 14(10): 1037-1052.
9.Su C#, Li XX#, Yang YX, Du Y, Zhang XM, Wang L*, Hong B*. Metformin Alleviates Choline Diet-Induced TMAO Elevation in C57BL/6J Mice by Influencing Gut-Microbiota Composition and Functionality. Nutr Diabetes, 2021, 11(1): 27.
10.Li XX#, Yu TF#, He Q#, McDowall KJ, Jiang BY, Jiang ZB, Wu LZ, Li GW, Li QL, Wang SM, Shi YY, Wang LF*, Hong B*, Binding of a Biosynthetic Intermediate to AtrA Modulates the Production of Lidamycin by Streptomyces globisporus. Mol Microbiol, 2015, 96(6): 1257-1271.

1.一组具有抗病毒活性的肽类化合物奥米克欣及其应用（发明人：司书毅，洪斌，李玉环，孙红敏，蒋建东，李星星，陈明华，高荣梅，车永胜，甄心，余利岩，刘红宇，钟鸣，李妍，巫晔翔，侍媛媛），专利号：ZL202010097607.1，授权日：2022.11.08
2.一种参与脂质代谢的新型化合物及其制备方法（发明人：洪斌，江志波，李星星，任卫聪，武临专，杜郁，胡笑文，侍媛媛，王丽非，张秀敏），专利号：ZL202010550502.7，授权日：2022.06.03
3.一组杀粉蝶菌素（Piericidin）的制备方法及其应用（发明人：洪斌，王丽，解云英，何维，李星星，孙红敏，侍媛媛，张秀敏，杜郁），专利号：ZL202010826262.9，授权日：2022.05.27
4.Herbicidin生物合成基因簇及其应用（发明人：洪斌，解云英，侍媛媛，谷仁杰，李怡宏，王新位，任卫聪，李星星，王丽非，张丛），专利号：ZL201910471680.8，授权日：2021.02.09
5.一组生物合成创新霉素或开环创新霉素的基因簇（发明人：洪斌，侍媛媛，武临专，蒋建东，江志波，李星星，左利杰，雷璇），专利号：ZL201710584431.0，授权日：2020.07.24

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