生物医药

生物大分子和细胞类物质的活性及成药性研究

1.Rui‑fang Zheng†, Kaderyea Kader†, Di‑wei Liu, Wen‑ling Su, Lei Xu, Yuan‑yuan Jin* and Jian‑guo Xing*. A network pharmacology approach to decipher the mechanism of total flavonoids from Dracocephalum Moldavica L. in the treatment of cardiovascular diseases. BMC Complementary Medicine and Therapies. 2024,24:15.
2.Lihua Cui#, Yuanyuan Jin#, Sen Zou, Jing Xun, Xiangyang Yu, Qi Zhang*, Zhaoyong Yang*. The antitumor activity of hPRDX5 against pancreatic cancer and the possible mechanisms. BRAZ J MED BIOL RES(Q2) 2022; 55: e12324.
3.Xiao Feng, Shuai Fan, Guangxin Lv, Maocai Yan, Guangteng Wu, Yuanyuan Jin*, Zhaoyong Yang*. Expression, purification and X-ray crystal diffraction analysis of alcohol dehydrogenase 1 from Artemisia annua L. Protein Expression and Purification 2021, 187:105943.
4.Yuan-yuan Jin#, Wen-zhuo Yang#, NK cells adjuvant therapy shows survival benefits in a gastric mixed signet ring cell carcinoma patient: A case report. Medicine 2021, 100(10): e24979.
5.Yuying Ji#, Rui Cao#, Guangxin Lv, Yuanyuan Jin*, Jing Chen*, Identification of Functional Fragments in gMYL6 and the Mechanism Exploration in Improving NK Cell-Mediated Cytotoxicity. Iran J Immunol. 2020; 17(4): 292-302.
6.Yuan-yuan Jin#, Wen-zhuo Yang#, Sen Zou, Zheng-yang Sun, Chun-tao Wu, Zhao-yong Yang, Chemoradiotherapy combined with NK cell transfer in a patient with recurrent and metastatic nasopharyngeal carcinoma inducing long-term tumor control. Medicine 2020, 99(43):e22785.
7.Zou S, Liu J, Sun Z, Feng X, Wang Z, JinY*, YangZ*. Discovery of hPRDX5-based peptide inhibitors blocking PD-1/PD-L1 interaction through in silico proteolysis and rational design. Cancer Chemother Pharmacol 2020,85(1):185-193.
8.Juanjuan Liu#, Yuanyuan Jin#, Xiaozhou Feng, Sen Zou, Guangxin Lv, Zhifei Zhang*, Zhaoyong Yang*. Solubility-enhanced gMYL6 fused with a hexa-lysine tag promotes the cytotoxicity of human NK cells. Immunology Letters 2018, 198: 66-73.
9.Linhu Li#，Yuanyuan Jin#，Bin Wang, Zhaoyong Yang, Mingliang Liu, Huiyuan Guo, Jun Zhang, Yu Lu. A Structure-based Strategy toward the development of novel candidates for antimycobacterial activity: Synthesis, biological evaluation and docking study. Chem Biol Drug Des 2018, 91(3):769-780.
10.Yuanyuan Jin#，Ya-dong Li#，Wan Sun，Shuai Fan，Xiao-zhou Feng，Kang-youWang，Wei-qing He*，Zhao-yong Yang*. The whole-cell immobilization of D-hydantoinase-engineered Escherichia coli for D-CpHPG biosynthesis. Electronic Journal of Biotechnology 2016, 21, 43-48.
11.Mei-Yan Wang#, Yuan-Yuan Jin#, Hui-Yu Wei, Li-Song Zhang, Su-Xia Sun, Xiu-Bo Chen, Wei-Li Dong, Wei-Ren Xu, Xian-Chao Cheng*, Run-Ling Wang*. Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors. European Journal of Medicinal Chemistry 2015, 103, 91-104.
12.Xiaodong Liu, Yuanyuan Jin, Zheng Cui, Koichi Nonaka, Satoshi Baba, Masanori Funabashi, Zhaoyong Yang, Steven G. Van Lanen*. The Role of a Nonribosomal Peptide Synthetase in L-Lysine Lactamization During Capuramycin Biosynthesis. ChemBioChem 2016, 17(9):804-810.
13.Xiaodong Liu, Yuanyuan Jin, Wenlong Cai, Keith D. Green, Anwesha Goswami, Sylvie Garneau-Tsodikova, Koichi Nonaka, Satoshi Baba, Masanori Funabashi, Zhaoyong Yang* and Steven G. Van Lanen*. A biocatalytic approach to capuramycin analogues by exploiting a substrate permissive N-transacylase CapW. Org Biomol Chem 2016, 14, 3956-3962.

1. 一种脐血源NK细胞的体外扩增培养方法及其制备试剂盒（杨兆勇、金媛媛、韩强、孙正阳、杨文卓、樊帅、王忠博、刘坤），专利号 ZL202111208066.6，授权日 2023年3月24日
2. 一种具有抗肿瘤活性的多肽IMB-P1及其应用（杨兆勇、刘娟娟、金媛媛、樊帅、陈静、张志斐、孙正阳），专利号 ZL201810070903.5，授权日 2022年2月11日
3. 一种洋橄榄叶素衍生物的制备方法（杨兆勇、金媛媛、刘玉凤、王保国、樊帅、吕广新、张倩），专利号 ZL202011146085.6 授权日 2021年10月22日
4. 一种靶向PD1/PDL1相互作用的抗肿瘤活性多肽IMB-P6及其应用（杨兆勇、金媛媛、刘娟娟、樊帅、张志斐、孟浩毅）专利号 ZL201810070905.4 授权日 2021年9月24日
5. 一种具有增强脐血来源NK细胞杀伤活性的多肽及其应用（杨兆勇、姬钰滢，金媛媛，陈静，邹森，樊帅，王忠博，石北辰，孙正阳）专利号 ZL202010139042.9 授权日 2021年9月24日
6. 洋橄榄叶素衍生物在制备抗肿瘤药物中的应用（杨兆勇、刘玉凤、金媛媛、王保国、樊帅）专利号 ZL202010993616.9 授权日 2021年8月6日
7．一种具有抗肿瘤作用的宿主因子hPRDX5、编码基因及其应用（杨兆勇，金媛媛，邹森，樊帅，冯晓，吕广新，王忠博，张琦）专利号 ZL201910434270.6 授权日 2020年11月13日

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