生物医药

药物毒理学、计算系统毒理学

1. Xinyan Ma#, Ruixian Guo#, Huibo Xu, Yuanyuan Ma, Rui Zhang, Xinyan Liu, Jingpu Zhang*, Ying Han*, Developmental adcyap1b loss leads to hemorrhage, disrupted hemostasis, and a blood coagulation cascade in zebrafish, J Thromb Haemost. 2023, 1–14. https://doi.org/10.1016/j.jtha.2023.12.010
2. Ruixian Guo#, Xinyan Ma#, Huibo Xu, Yuanyuan Ma, Rui Zhang, Xinyan Liu, Binan Lu, Jingpu Zhang*, Ying Han*, In silico prediction and a systematic toxicology-based in vivo investigation uncovering the mechanism of aquatic toxicity caused by beta-lactam antibiotics, Chemosphere, 2024, 349: 140884.
3. Ying Han, Yuanyuan Ma, Junwei Tong, Jingpu Zhang*, Changqin Hu*, Systems assessment of statins hazard: Integrating in silico prediction, developmental toxicity profile and transcriptomics in zebrafish, Ecotoxicol. Environ. Saf., 2022, 243: 113981.
4. Ying Han, Yuanyuan Ma, Bo Chen, Jingpu Zhang*, Changqin Hu*, Hazard assessment of betalactams: Integrating in silico and QSTR approaches with in vivo zebrafish embryo toxicity testing, Ecotoxicol. Environ. Saf., 2022, 229: 113106.
5. Ying Han, Yuanyuan Ma, Shangchen Yao, Jingpu Zhang*, Changqin Hu*, In vivo and in silico evaluations of survival and cardiac developmental toxicity of quinolone antibiotics in zebrafish embryos (Danio rerio), Environ. Pollut., 2021, 227: 116779.
6. Rui xian Guo, Junping Lv, Huibo Xu, Yinghui Bai, Binan Lu*, Ying Han*, A systems toxicology approach to explore toxicological mechanisms of fluoroquinolones-induced testis injury, Ecotoxicol. Environ. Saf., 2021, 228: 113002.
7. Ying Han, Jingpu Zhang*, Chang Qin Hu*, Xia Zhang, Bufang Ma, Peipei Zhang, In silico ADME and toxicity prediction of ceftazidime and its impurities. Front. Pharmacol., 2019, 10: 434.
8. Ying Han, Jingpu Zhang*, Changqin Hu*, A systematic toxicity evaluation of cephalosporins via transcriptomics in zebrafish and in silico ADMET studies, Food Chem. Toxicol., 2018, 116: 264-271.
9. Ying Han, Bo Chen, Jingpu Zhang*, Changqin Hu*, Cardiac safety evaluation in zebrafish and in silico ADME prediction of cephalosporins with an aminothiazoyl ring at the C-7 position, Toxicol. Appl. Pharmacol., 2018, 347: 33–44.
10. Ying Han, Jianqin Qian, Jingpu Zhang*, Changqin Hu*, ChenWang, Structure-toxicity relationship of cefoperazone and its impurities to developing zebrafish by transcriptome and Raman analysis, Toxicol. Appl. Pharmacol., 2017, 327: 39–51.

1. 韩莹，张靖溥，国瑞贤，马媛媛，陈博，张苗青，刘馨妍，张锐。一种sgRNA组合及其应用、斑马鱼Adcyap1b基因突变体模型及其构建方法，中国，申请号202310221769.5
2. 韩莹，马媛媛，张靖溥，马鑫彦，张锐，杜纪阳，刘可慧，刘馨妍。突变体斑马鱼在制备凝血功能障碍疾病的动物模型中的应用，中国，申请号202311609786.2
3. 韩莹，张靖溥，杜纪阳，刘可慧，马媛媛，张锐，马鑫彦。一种sgRNA组合及其应用,中国,申请号202311615919.7
4. 马媛媛，张靖溥，韩莹，陈博，张苗青，张锐，刘馨妍。一种敲除斑马鱼ddx18基因的sgRNA组合及其应用中国，申请号202310222452.3

技术咨询