1. 基于代谢组学等多组学分析的疾病关键致病网络分析与研究
2. 智能化抗肿瘤的免疫治疗药物研究与发现

1. 企业联合药物合作开发项目，2025年，主持
2. 科技部国家重大新药研发项目，2023年，骨干
3. 上海市科技创新行动计划，启明星项目，2021年，主持
4. 国家自然科学基金，2021年，参与
5. 国家自然科学基金，2019年，主持
1. 基于代谢组学等多组学分析的疾病关键致病网络分析与研究
2. 智能化抗肿瘤的免疫治疗药物研究与发现
代表性论著
1. Bai Y, Zhou R, Xie X, Zhu A, Nan Y, Wu T, Hu X, Cao Z, Ju D, Fan J. A Novel Bifunctional Fusion Protein (Anti-IL-17A-sST2) Protects against Acute Liver Failure, Modulating the TLR4/MyD88 Pathway and NLRP3 Inflammasome Activation. Biomedicines. 2024;12:1118. Corresponding Author
2. Bai Y, Nan Y, Wu T, Zhu A, Xie X, Sun Y, Deng Y, Dou Z, Hu X, Zhou R, Xu S, Zhang Y, Fan J, Ju D. Lipid Nanoparticle-Mediated Delivery of CRISPR-Cas9 Against Rubicon Ameliorates NAFLD by Modulating CD36 Along with Glycerophospholipid Metabolism. Adv Sci. 2024:e2400493. Co-Corresponding Author
3. Zhang Y, Xin W, Hu X, Wang H, Ye X, Xu C, Nan Y, Wu Z, Ju D, Fan J. Inhibition of Hedgehog signaling ameliorates foam cell formation by promoting autophagy in early atherosclerosis. Cell Death Dis. 2023;14:740. Corresponding Author
4. Han L, Shi C, Zeng X, Cen L, Mei X, Fan J, Ju D, Zhu H. A Novel Bifunctional Fusion Protein, Vunakizumab-IL22, for Protection Against Pulmonary Immune Injury Caused by Influenza Virus. Front Immunol. 2021;12:727941. Co-Corresponding Author
5. Fan J, Zhang X, Wang S, Chen W, Li Y, Zeng X, Wang Y, Luan J, Li L, Wang Z, Sun X, Shen B, Ju D. Regulating autophagy facilitated therapeutic efficacy of the sonic Hedgehog pathway inhibition on lung adenocarcinoma through GLI2 suppression and ROS production. Cell Death Dis. 2019;10: 626. First Author
6. Fan J, Zhang P, Chen W, Luan J, Song H, Mao Y, Liu ML, Ju D. Macrophages Are Disarmed by CD 47+ Microvesicles for Their Impaired Phagocytotic Capability in Atherosclerosis. Circ Res. 2018;123:e69-e81. No. 19664. First Author