生物医药

多能性转录因子以及细胞在不同状态（间质及上皮）间的相互转化调控体细胞重编程、细胞转分化以及肿瘤发生和发展过程的具体机制

[37] Liang L#, He M#, Zhang Y#, Wang C, Qin Z, Li Q, Yang T, Meng F, Zhou Y, Ge H, Song W, Chen S, Dong L, Ren Q, Li C, Guo L, Sun H, Zhang W, Pei D*, Zheng H* Unraveling the 2,3–diketo–L–gulonic acid–dependent and –independent impacts of L–ascorbic acid on somatic cell reprogramming. Cell & Bioscience. 2023 Nov 30;13(1):218.
[36] Li C*#, He J#, Meng F#, Wang F#, Sun H, Zhang H, Zhang M, Xu Q, Liang L, Li Y, Yang T, He M, Wang T, Lin J, Sun J, Huang Q, Guo L, Zhang X, Mai S*, Zheng H*. Nuclear Localization of TET2 Requires β-catenin Activation and Correlates with Favourable Prognosis in Colorectal Cancer. Cell Death & Disease. 2023 Aug 24;14(8):552.
[35] Li Y#, Yang T#, Cheng Y#, Hou J#, Liu Z, Zhao Y, Chen S, Qin Z, Wang C, Song W, Ge H, Li C, Liang L, Guo L, Sun H, Wu LP*, Zheng H*. Low glutaminase and glycolysis correlate with a high transdifferentiation efficiency in mouse cortex. Cell Proliferation. 2023 May;56(5):e13422.
[34] Sun J#*, Yang J, Miao X, Loh HH, Pei D, Zheng H*. Proteins in DNA methylation and their role in neural stem cell proliferation and differentiation. Cell Regeneration. 2021 Mar 2;10(1):7.
[33] Meng F#, Li Y, Sun H, Li C, Li Q, Law PY, Loh HH, Liang L*, Zheng H*. Naloxone Facilitates Contextual Learning and Memory in a Receptor-Independent and Tet1-Dependent Manner. Cellular and Molecular Neurobiology. 2021 Jul;41(5):1031-1038.
[32] Zhang M#, Li Q, Yang T, Meng F, Lai X, Liang L, Li C, Sun H, Sun J, Zheng H*. Positive feedback between retinoic acid and 2-phospho-L-ascorbic acid trisodium salt during somatic cell reprogramming. Cell Regeneration. 2020 Oct 1;9(1):17.
[31] Lai X#, Li Q#, Wu F, Lin J, Chen J*, Zheng H*, Guo L*. Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming. Frontiers in Cell and Developmental Biology. 2020 Aug 6;8:760.
[30] Chen J#, Liang L#, Li Y, Zhang Y, Zhang M, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Law PY, Loh HH, Pei D, Sun H*, Zheng H*. Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway. The FASEB Journal. 2020 Apr;34(4):5917-5930.
[29] Liang L#, Chen J#, Li Y, Lai X, Sun H, Li C, Zhang M, Yang T, Meng F, Law PY, Loh HH, Zheng H*. Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway. Cell Reports. 2020 Mar 17;30(11):3625-3631.
[28] Sun H#, Yang X#, Liang L#, Zhang M#, Li Y, Chen J, Wang F, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Lin L, Pei D*, Zheng H*. Metabolic switch and epithelial-mesenchymal transition cooperate to regulate pluripotency. The EMBO Journal. 2020 Apr 15;39(8):e102961.
[27] He S#, Wang F#, Zhang Y#, Chen J, Liang L, Li Y, Zhang M, Yang X, Pang H, Li Y, Huang X, Qin D, Pei D, Sun H*, Zheng H*. Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming. Cell Discovery. 2019 Feb 12;5:11.
[26] Lin L#, Liang L#, Yang X#, Sun H, Li Y, Pei D, Zheng H*. The homeobox transcription factor MSX2 partially mediates the effects of bone morphogenetic protein 4 (BMP4) on somatic cell reprogramming. The Journal of Biological Chemistry. 2018 Sep 21;293(38):14905-14915.
[25] He S#, Sun H#, Lin L, Zhang Y, Chen J, Liang L, Li Y, Zhang M, Yang X, Wang X, Wang F, Zhu F, Chen J, Pei D, Zheng H*. Passive DNA demethylation preferentially up-regulates pluripotency-related genes and facilitates the generation of induced pluripotent stem cells. The Journal of Biological Chemistry. 2017 Nov 10;292(45):18542-18555.
[24] He S#, Chen J#, Zhang Y#, Zhang M, Yang X, Li Y, Sun H, Lin L, Fan K, Liang L, Feng C, Wang F, Zhang X, Guo Y, Pei D*, Zheng H*. Sequential EMT-MET induces neuronal conversion through Sox2. Cell Discovery. 2017 May 30;3:17017.
[23] Liang L#, Sun H, Li L, Zheng H*. Transitions between mesenchymal and epithelial states and the concomitant gene expression changes. Science Foundation in China. 2016,24(1):50-62.
[22] Li L#, He S, Zheng H*. The Abilities of ShDNMT1 to Promote Reprogramming are Enhanced by Vitamin C-recused Proliferation. China Biotechnology. 2016, 36(6): 1-8.
[21] Sun H#, Liang L, Li Y, Feng C, Li L, Zhang Y, He S, Pei D, Guo Y*, Zheng H*. Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch. Scientific Reports. 2016 Aug 2;6:30903.
[20] Liang L#, Sun H#, Zhang W, Zhang M, Yang X, Kuang R, Zheng H*. Meta-Analysis of EMT Datasets Reveals Different Types of EMT. PLoS One. 2016 Jun 3;11(6):e0156839.
[19] Huang Z#, Liang L#, Li L#, Xu M, Li X, Sun H, He S, Lin L, Zhang Y, Song Y, Yang M, Luo Y, Loh HH, Law PY, Zheng D*, Zheng H*. Opioid doses required for pain management in lung cancer patients with different cholesterol levels: negative correlation between opioid doses and cholesterol levels. Lipids in Health and Disease. 2016 Mar 8;15:47.
[18] Chen J#, Li W, Li Y, He S, Li L, Liang L, Song Y, Qin D*, Zheng H*. MicroRNA-128-3p impaired water maze learning by suppressing Doublecortin expression in both wild type and Aβ-42 infused mice. Neuroscience Letters. 2016 Jul 28;626:79-85.
[17] He S#, Guo Y, Zhang Y, Li Y, Feng C, Li X, Lin L, Guo L, Wang H, Liu C, Zheng Y, Luo C, Liu Q, Wang F, Sun H, Liang L, Li L, Su H, Chen J, Pei D*, Zheng H*. Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo. Cell Regeneration. 2015 Dec 30;4:12.
[16] Zheng H#, Hutchins AP, Pan G, Li Y, Pei D*, Pei G*. Where cell fate conversions meet Chinese philosophy. Cell Research. 2014 Oct;24(10):1162-3.
[15] Li X#, Pei D, Zheng H*. Transitions between epithelial and mesenchymal states during cell fate conversions. Protein Cell. 2014;5(8):580-91.
[14] Li W#, He S#, Zhou Y, Li Y, Hao J, Zhou X, Wang F, Zhang Y, Huang Z, Li Z, Loh HH, Law PY, Zheng H*. Neurod1 modulates opioid antinociceptive tolerance via two distinct mechanisms. Biological Psychiatry. 2014 Nov 15;76(10):775-84.
[13] Zheng H*#, Zhang Y, Li W, Loh HH, Law PY. NeuroD modulates opioid agonist-selective regulation of adult neurogenesis and contextual memory extinction. Neuropsychopharmacology. 2013 Apr;38(5):770-7.
[12] Zheng H*#, Loh HH, Law PY. Posttranslation modification of G protein-coupled receptor in relationship to biased agonism. Methods in Enzymology. 2013;522:391-408.
[11] Liu X#, Sun H, Qi J, Wang L, He S, Liu J, Feng C, Chen C, Li W, Guo Y, Qin D, Pan G, Chen J, Pei D*, Zheng H*. Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nature Cell Biology. 2013 Jul;15(7):829-38.
[10] Zheng H*#, Zou H, Liu X, Chu J, Zhou Y, Loh HH, Law PY. Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans. Journal of Lipid Research. 2012 Jun;53(6):1153-62.
[9] Zheng H*#, Pearsall EA, Hurst DP, Zhang Y, Chu J, Zhou Y, Reggio PH, Loh HH, Law PY. Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling. BMC Cell Biology. 2012 Mar 19;13:6.
[8] Zheng H*#, Law PY, Loh HH. Non-Coding RNAs Regulating Morphine Function: With Emphasis on the In vivo and In vitro Functions of miR-190. Frontiers in Genetics. 2012 Jun 15;3:113.
[7] Zheng H*#, Chu J, Zhang Y, Loh HH, Law PY. Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability. The Journal of Biological Chemistry. 2011 Apr 8;286(14):12724-33.
[6] Zheng H*#, Zeng Y, Zhang X, Chu J, Loh HH, Law PY. mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD. Molecular Pharmacology. 2010 Jan;77(1):102-9.
[5] Zheng H*#, Zeng Y, Chu J, Kam AY, Loh HH, Law PY. Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability. Journal of Neuroscience. 2010 Jun 16;30(24):8102-10.
[4] Zheng H*#, Loh HH, Law PY. Agonist-selective signaling of G protein-coupled receptor: mechanisms and implications. IUBMB Life. 2010 Feb;62(2):112-9.
[3] Zheng H*#, Chu J, Zeng Y, Loh HH, Law PY. Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression. The Journal of Biological Chemistry. 2010 Jul 16;285(29):21994-2002.
[2] Zheng H*#, Loh HH, Law PY. Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activation. Molecular Pharmacology. 2008 Jan;73(1):178-90.
[1] Zheng H*#, Chu J, Qiu Y, Loh HH, Law PY. Agonist-selective signaling is determined by the receptor location within the membrane domains. Proceedings of the National Academy of Sciences of the United States of America. 2008 Jul 8;105(27):9421-6.