生物医药

研究方向一：单细胞多组学与谱系示踪技术解析细胞谱系的功能分群与异质性
研究方向二：原位空间多组学技术解析空间功能特异的细胞调控特征
研究方向三：新型多能干细胞用于体外器官重建与功能修复

1. Lin L, Zhong J, Jiang F, Wang Y, Ma L, Yang J, Li Y, Gao R-R, Feng H, Cai B, Feng Z, Zhou X, Shu Y, Chen P, Wu X, Cai C-L, Wang Q, Wu G, Pei D*, Cao S*, Liu Y*, Peng G*, Chen J* & Chen Q* (2026) A single-cell time-series atlas of endothelial cell embryonic development. Cell, S0092867426000498.
2. Qian Y, Zhu M, Ren C, Zhou Y, Xu J, Dong L, Zhang G, Li C, Lv J, Xing Q*, Zhang G*, Peng G* & Liao N* (2026) Spatial Chromatin Accessibility Analysis of Intratumor Heterogeneity in Breast Cancer. Genomics, Proteomics & Bioinformatics, qzag001.
3. Guo C-K, Xia C-R, Peng G*, Cao Z-J* & Gao G* (2025) Learning Phenotype Associated Signature in Spatial Transcriptomics with PASSAGE. Small Methods, e2401451.
4. Meng X, Li W, Xu J, Yao Y, Gong A, Yang Y, Qu F, Guo C, Zheng H, Cui G*, Suo S* & Peng G* (2025) Spatiotemporal transcriptome atlas of developing mouse lung. Science Bulletin 70, 1641–1658.
5. Ke J, Xu J, Liu J, Yang Y, Guo C, Xie B, Cui G, Peng G* & Suo S* (2025) High-resolution mapping of single cells in spatial context. Nat Commun 16, 6533.
6. Yang X, Li C, He J, Xie B, Lv L, Xu J, Lin Y, Zhou C, Li M, Zeng Z, Tan J, Chen S, Cui G, Liu G*, Suo S*, Peng G* & Liang X* (2025) Spatial and single-cell transcriptomics landscape of adenomyosis. Journal of Advanced Research, S209012322501032X.
7. Chen C, Liao Y, Zhu M, Wang L, Yu X, Li M & Peng G* (2025) Dual-nuclease single-cell lineage tracing by Cas9 and Cas12a. Cell Reports 44, 115105.
8. Zhang G, Zhang X, Pan W, Chen X, Wan L, Liu C, Yong Y, Zhao Y, Sang S, Zhang L, Yao S, Guo Y, Wang M, Wang X, Peng G*, Yan X*, Wang Y* & Zhang M* (2025) Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer. Advanced Science, 2413019.
9. Jiang F, Wang H, Li Z, Cui G & Peng G* (2024) Leveraging spatial multiomics to unravel tissue architecture in embryo development. Trends in Genetics, S0168952524002713.
10. Zou S, Peng G* & Ma Z* (2024) Surface-Functionalizing Strategies for Multiplexed Molecular Biosensing: Developments Powered by Advancements in Nanotechnologies. Nanomaterials.
11. Wang Z, Li Z, Luan T, Cui G, Shu S, Liang Y, Zhang K, Xiao J, Yu W, Cui J, Li A*, Peng G* & Fang Y* (2024) A spatiotemporal molecular atlas of mouse spinal cord injury identifies a distinct astrocyte subpopulation and therapeutic potential of IGFBP2. Developmental Cell 59, 2787-2803.e8.
12. Fan Y, Bian X, Meng X, Li L, Fu L, Zhang Y, Wang L, Zhang Y, Gao D, Guo X, Lammi MJ, Peng G* & Sun S* (2024) Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration. Annals of the Rheumatic Diseases 83, 926–944.
13. Jiang F, Zhou X, Qian Y, Zhu M, Wang L, Li Z, Shen Q, Wang M, Qu F, Cui G, Chen K & Peng G* (2023) Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development. Nat Methods 20, 1048–1057.
14. Qu F, Li W, Xu J, Zhang R, Ke J, Ren X, Meng X, Qin L, Zhang J, Lu F, Zhou X, Luo X, Zhang Z, Wang M, Wu G, Pei D, Chen J, Cui G*, Suo S* & Peng G* (2023) Three-dimensional molecular architecture of mouse organogenesis. Nat Commun 14, 4599.
15. Xu HJ, Yao Y, Yao F, Chen J, Li M, Yang X, Li S, Lu F, Hu P, He S*, Peng G* & Jing N* (2023) Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells. Cell Regen 12, 15.
16. Meng X, Cui G* & Peng G* (2023) Lung development and regeneration: newly defined cell types and progenitor status. Cell Regen 12, 5.
17. Wen L, Li G, Huang T, Geng W, Pei H, Yang J, Zhu M, Zhang P, Hou R, Tian G, Su W, Chen J, Zhang D, Zhu P, Zhang W, Zhang X, Zhang N, Zhao Y, Cao X*, Peng G*, Ren X*, Jiang N*, Tian C* & Chen Z-J* (2022) Single-cell technologies: From research to application. The Innovation 3, 100342.
18. Chen C, Liao Y & Peng G* (2022) Connecting past and present: single-cell lineage tracing. Protein Cell 13, 790–807.
19. Cui G, Feng S, Yan Y, Wang L, He X, Li X, Duan Y, Chen J, Tang K, Zheng P, Tam PPL, Si W*, Jing N* & Peng G* (2022) Spatial molecular anatomy of germ layers in the gastrulating cynomolgus monkey embryo. Cell Reports 40, 111285.
20. Li Z & Peng G* (2022) Spatial transcriptomics: new dimension of understanding biological complexity. Biophysics Reports 8, 119–135.
21. Xia Q, Cui G, Fan Y, Wang X, Hu G, Wang L, Luo X, Yang L, Cai Q, Xu K, Guo W, Gao M, Li Y, Wu J, Li W, Chen J, Qi H, Peng G* & Yao H* (2021) RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes. Cell Proliferation 54, e13000.
22. Lin J, Wu S, Shen Q, Liu J, Huang S, Peng G* & Qiao Y* (2021) Base editing‐mediated perturbation of endogenous PKM1/2 splicing facilitates isoform‐specific functional analysis in vitro and in vivo. Cell Proliferation 54, e13096.
23. Peng G*, Cui G, Ke J & Jing N* (2020) Using Single-Cell and Spatial Transcriptomes to Understand Stem Cell Lineage Specification During Early Embryo Development. Annu Rev Genom Hum Genet 21, 163–181.
24. Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G*, Ji H* & Zhou B* (2019) Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet 51, 728–738.
25. Peng G*, Suo S, Cui G, Yu F, Wang R, Chen J, Chen S, Liu Z, Chen G, Qian Y, Tam PPL, Han J-DJ* & Jing N* (2019) Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature 572, 528–532.
26. Cui G, Jing N & Peng G* (2019) Comments on ‘Molecular architecture of lineage allocation and tissue organization in early mouse embryo.’ Journal of Molecular Cell Biology 11, 1024–1025.
27. Peng G* & Han J-DJ* (2018) Regulatory network characterization in development: challenges and opportunities. F1000Res 7, 1477.
28. Cui G, Suo S, Wang R, Qian Y, Han JJ, Peng G*, Tam PPL* & Jing N* (2018) Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning. Dev Growth Differ 60, 463–472.
29. Peng G* & Jing N* (2017) The genome-wide molecular regulation of mouse gastrulation embryo. Sci China Life Sci 60, 363–369.
30. Chen J, Suo S, Tam PP, Han J-DJ*, Peng G* & Jing N* (2017) Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq. Nat Protoc 12, 566–580.

中国科学院“器官重建与制造”A类战略性先导科技专项
国家重点研发计划“干细胞及转化研究”重点专项
国家重点研发计划“发育编程及其代谢调控”重点专项
国家重点人才计划高层次青年人才项目
国家自然科学基金面上项目
广东省自然科学基金杰出青年项目
国家重点研发计划“前沿生物技术”重点专项，项目首席