生物医药

心脏发育学与干细胞生物学的基础研究，以及细胞谱系示踪技术的发展和完善，利用谱系示踪技术研究心脏祖细胞的分化规律和心肌受损后各种干细胞的分化规律，推动心脏发育学的研究进步。

1. Ruan J, Zhang L, Hu D, Qu X, Yang F, Chen F, He X, Shen J, Dong K, Sweet M, Sanchez C, Li D, Shou W, Zhou J, Cai CL: Novel Myh11 Dual Reporter Mouse Model Provides Definitive Labeling and Identification of Smooth Muscle Cells. Arterioscler Thromb Vasc Biol 2020:ATVBAHA120315107.
2. Hu D, Zhang L, Yang F, Chen F, Li D, Cai CL: Generation of Pecam1 endothelial specific dual reporter mouse model. Genesis 2020, 58(9):e23384.
3. Zhang L, Sultana N, Yan J, Yang F, Chen F, Chepurko E, Yang FC, Du Q, Zangi L, Xu M, Bu L, Cai CL: Cardiac Sca-1(+) Cells Are Not Intrinsic Stem Cells for Myocardial Development, Renewal, and Repair. Circulation 2018, 138(25):2919-2930.
4. Yan J, Zhang L, Sultana N, Oh JG, Wu B, Hajjar RJ, Zhou B, Cai CL: A series of robust genetic indicators for definitive identification of cardiomyocytes. J Mol Cell Cardiol 2016, 97:278-285.
5. Sultana N, Zhang L, Yan J, Chen J, Cai W, Razzaque S, Jeong D, Sheng W, Bu L, Xu M, Huang GY, Hajjar RJ, Zhou B, Moon A, Cai CL: Resident c-kit(+) cells in the heart are not cardiac stem cells. Nat Commun 2015, 6:8701.
6. Yan J, Zhang L, Sultana N, Park DS, Shekhar A, Bu L, Hu J, Razzaque S, Cai CL: A Murine Myh6MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction. PLoS One 2015, 10(7):e0133472.
7. Yan J, Sultana N, Zhang L, Park DS, Shekhar A, Hu J, Bu L, Cai CL: Generation of a tamoxifen inducible Tnnt2MerCreMer knock-in mouse model for cardiac studies. Genesis 2015, 53(6):377-386.
8. Zhang L, Nomura-Kitabayashi A, Sultana N, Cai W, Cai X, Moon AM, Cai CL: Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development. Dev Biol 2014, 390(1):68-79.