生物医药

1. 肿瘤进展过程中的细胞命运转变（增殖+转移）。
2. 肿瘤细胞增殖和转移的体内外模型构建。
3. EMT转变和表观遗传的交互调控。

1. Li CP#, Cai MY#, Jiang LJ#, Mai SJ, Chen JW, Wang FW, Liao YJ, Chen WH, Jin XH, Pei XQ, Guan XY, Zeng MS, Xie D*.CLDN14 is epigenetically silenced by EZH2-mediated H3K27ME3 and is a novel prognostic biomarker in hepatocellular carcinoma. Carcinogenesis. 2016 Jun;37(6):557-566.
2. Jiang L#, Dong P#, Zhang Z#, Li C#, Li Y, Liao Y, Li X, Wu Z, Guo S, Mai S, Xie D, Liu Z, Zhou F*. Akt phosphorylates Prohibitin 1 to mediate its mitochondrial localization and promote proliferation of bladder cancer cells. Cell Death Dis. 2015 Feb 26;6(2):e1660.
3. Zhang M, Li Q, Yang T, Meng F, Lai X, Liang L, Li C, Sun H, Sun J, Zheng H*.Positive feedback between retinoic acid and 2-phospho-L-ascorbic acid trisodium salt during somatic cell reprogramming. Cell Regen. 2020 Oct 1;9(1):17.
4. Meng F, Li Y, Sun H, Li C, Li Q, Law PY, Loh HH, Liang L, Zheng H. Naloxone Facilitates Contextual Learning and Memory in a Receptor-Independent and Tet1-Dependent Manner. Cell Mol Neurobiol. 2020 Sep 28. doi: 10.1007/s10571-020-00970-8.
5. Sun H, Yang X, Liang L, Zhang M, Li Y, Chen J, Wang F, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Lin L, Pei D, Zheng H. Metabolic switch and epithelial-mesenchymal transition cooperate to regulate pluripotency. EMBO J. 2020 Apr 15;39(8):e102961. doi: 10.15252/embj.2019102961.

1. “一类可提高维生素C抗肿瘤效果的药物组合物”、郑辉、李长朋、王付卉、申请号：PIDC3205852，已受理；

1. 国家自然科学基金青年基金项目（2017年），项目负责人。
2. 广州市科技计划项目（2021年），项目负责人。

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