生物医药

细胞命运决定过程中的表观遗传调控机制
1. 体细胞重编程过程中的表观遗传机制研究；
2. 在细胞命运转变过程中研究高级染色质结构对基因表达乃至细胞命运的调控。

1、Cao, S.#, S. Yu#, D. Li#, J. Ye, X. Yang, C. Li, X. Wang, Y. Mai, Y. Qin, J. Wu, J. He, C. Zhou, H. Liu, B. Zhao, X. Shu, C. Wu, R. Chen, W. Chan, G. Pan, J. Chen, J. Liu and D. Pei (2018). "Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency." Cell Stem Cell 22(4): 529-542 e525.
2、Li, D#., J. Liu#, X. Yang#, C. Zhou, J. Guo, C. Wu, Y. Qin, L. Guo, J. He, S. Yu, H. Liu, X. Wang, F. Wu, J. Kuang, A. P. Hutchins, J. Chen and D. Pei (2017). "Chromatin Accessibility Dynamics during iPSC Reprogramming." Cell Stem Cell 21(6): 819-833 e816.
3、Liu, J#., M. Gao#, S. Xu, Y. Chen, K. Wu, H. Liu, J. Wang, X. Yang, J. Wang, W. Liu, X. Bao and J. Chen (2020). "YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways." Cell Rep 32(10): 108120.
4、Pei, R., J. Feng, Y. Zhang, H. Sun, L. Li, X. Yang, J. He, S. Xiao, J. Xiong, Y. Lin, K. Wen, H. Zhou, J. Chen, Z. Rong and X. Chen (2020). "Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection." Protein Cell.
5、Wang, B., L. Wu, D. Li, Y. Liu, J. Guo, C. Li, Y. Yao, Y. Wang, G. Zhao, X. Wang, M. Fu, H. Liu, S. Cao, C. Wu, S. Yu, C. Zhou, Y. Qin, J. Kuang, J. Ming, S. Chu, X. Yang, P. Zhu, G. Pan, J. Chen, J. Liu and D. Pei (2019). "Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4." Cell Rep 27(12): 3473-3485 e3475.
6、Zhou, Z., X. Yang, J. He, J. Liu, F. Wu, S. Yu, Y. Liu, R. Lin, H. Liu, Y. Cui, C. Zhou, X. Wang, J. Wu, S. Cao, L. Guo, L. Lin, T. Wang, X. Peng, B. Qiang, A. P. Hutchins, D. Pei and J. Chen (2017). "Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function." Cell Rep 21(8): 2160-2170.

1.国家自然科学基金青年基金（2020年），项目负责人；
2.“博士后创新人才计划”（2019年），项目负责人；
3.中国博士后科学基金面上项目（2019年），项目负责人