生物医药

线粒体新蛋白的发掘、鉴定，及其在多能干细胞以及代谢相关、心血管相关、肿瘤相关疾病中的功能研究

Hu Z#, Yang L#, Zhang M#, Tang H, Huang Y, Su Y, Ding Y, Li C, Wang M, Zhou Y, Zhang Q, Guo L, Wu Y, Wang Q, Liu N, Kang H, Wu Y, Yao D, Li Y, Ruan Z, Wang H, Bao F, Liu G, Wang J, Wang Y, Wang W, Lu G, Qin D, Pei D, Chan WY, Liu X. A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development. Cell Metabolism. 2024 Apr 29:S1550-4131(24)00132-3.
Yang L#, Huang Y#, Ding Y#, Hu Z#, Zhang S, Su H, Liu X. Impact of mtDNA-encoded proteins arising from cytosolic translation (mPACT). Science Bulletin. 2024 Dec 15;69(23):3648-3651.
Tang H#, Hu Z#, Yang L#, Ruan Z, Wang H, Zhou Y, Bao F, Liu X. OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation. Mitochondrial Communications. 2023; 1:16-22.
Yang L, Ruan Z, Lin X, Wang H, Xin Y, Tang H, Hu Z, Zhou Y, Wu Y, Wang J, Qin D, Lu G, Loomes KM, Chan WY, Liu X. NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations. Nature Communications. 2024 Jan 16;15(1):546.
Wu Y, Chen K, Xing G, Li L, Ma B, Hu Z, Duan L, Liu X. Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. Science Advances. 2019 Nov 27;5(11): eaax7525.
Yang L, Lin X, Tang H, Fan Y, Zeng S, Jia L, Li Y, Shi Y, He S, Wang H, Hu Z, Gong X, Liang X, Yang Y, Liu X. Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox. Aging Cell. 2020 Sep;19(9): e13206.
Yao D, Li Y, Zeng S, Li Z, Shah Z, Song B, Liu J, Wu Y, Yang L, Long Q, Wang W, Hu Z, Tang H, Liu X. Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space. Science China Life Science. 2022 Feb;65(2):227-235.

国家自然科学基金-青年科学基金项目（C类）（主持）
广东省自然科学基金面上基金（主持）
中国博士后科学基金第76批面上基金（主持）
中国科学院广州分院2024年度院长青年人才基金（主持）
国家自然科学基金委员会, 重大研究计划（参与）