生物医药

干细胞命运的代谢调控
线粒体糖脂代谢-表观遗传互作机制
非经典编码区翻译调控代谢与细胞命运

1. Liao R#, Wu Y#, Qin L, Jiang Z, Gou S, Zhou L, Hong Q, Li Y, Shi J, Yao Y, Lai L, Li Y, Liu P, Thiery JP, Qin D, Graf T, Liu X*, Li P*. BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells. EMBO Journal, 2023, 42(21), e113448.
2. Li L#*, Sun S#, Wu Y#, Lu J#, He J, Chen K, Chan WY, Liu X*. Lactate and protein lactylation: the ugly duckling of energy as the sculpture artist of proteins. Science Bulletin, 2023, 68(21), 2510-2514. (Cover)
3. Wu Y#, Chen K#, Li L#, Hao Z#, Wang T, Liu Y, Xing G, Liu Z, Li H, Yuan H, Lu J, Zhang C, Zhang J, Zhao D, Wang J, Nie J, Ye D, Pan G, Chan WY, Liu X*. Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation. Cell Death & Differentiation, 2022, 29(11), 2312-2331. (CDD Press Readers’ Choice)
4. Wu Y#, Liu Y#, Hao Z, Liu X*. NAD+ is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1. Life Medicine, 2022, 1(3), 401-405. (Most Picked Paper Award 2022)
5. Li L#, Chen K#, Wu Y#, Xiang G, Liu X*. Epigenome-Metabolome-Epigenome signaling cascade in cell biological processes. Journal of Genetics and Genomics, 2022, 49(4), 279-286.
6. Li L#, Chen K#, Wang T#, Wu Y#, Xing G, Chen M, Hao Z, Zhang C, Zhang J, Ma B, Liu Z, Yuan H, Liu Z, Long Q, Zhou Y, Qi J, Zhao D, Gao M, Pei D, Nie J, Ye D, Pan G, Liu X*. Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade. Nature Metabolism, 2020, 2(9), 882-892.
7. Wu Y, Chen K, Xiang G, Ying Z, Liu X*. Organelle remodeling during the acquistion and loss of pluripotency. Science Foundation in China, 2020, 28(1), 47-55. (Cover)
8. Wu Y#, Chen K#, Xing G, Li L, Ma B, Hu Z, Duan L, Liu X*. Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. Science Advances, 2019, 5(11), eaax7525.
9. Wu Y#, Chen K#, Liu X, Huang L, Zhao D, Li L, Gao M, Pei D, Wang C, Liu X*. (2016). Srebp-1 interacts with c-Myc to enhance somatic cell reprogramming. Stem Cells, 34(1), 83-92.

国家自然科学基金-面上项目（2020年，2023年），项目负责人
国家自然科学基金-青年科学基金项目（2019年），项目负责人
广东省自然科学基金-面上项目（2020年，2022年），项目负责人
广州市基础研究计划（2020年，2024年），项目负责人
国家重点研发计划-干细胞及转化研究重点专项（2018年），项目骨干