生物医药

·精准基因编辑技术开发及应用
·人类遗传疾病基因治疗
·早衰症机理及治疗研究
·心脏发育与再生生物学

1. Xie J*, Ge W*, Li N*, Liu Q*, Chen F, Yang X, Huang X, Ouyang Z, Zhang Q, Zhao Y, Liu Z, Gou S, Wu H, Lai C, Fan N, Jin Q, Shi H, Liang Y, Lan T, Quan L, Li X, Wang K, Lai L. Efficient base editing for multiple genes and loci in pigs using base editors[J]. Nature Communication, 2019, 10(1):2852.
2. Liang, Y.*, Xie, J.*, Zhang, Q.*, Wang, X.*, Gou, S., Lin, L., Chen, T., Ge, W., Zhuang, Z., Lian, M., Chen, F., Li, N., Ouyang, Z., Lai, C., Liu, X., Li, L., Ye, Y., Wu, H., Wang, K., & Lai, L. (2022). AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns. Nucleic acids research, 50(9), 5384–5399.
3. Xie, J.*, Huang, X.*, Wang, X., Gou, S., Liang, Y., Chen, F., Li, N., Ouyang, Z., Zhang, Q., Ge, W., Jin, Q., Shi, H., Zhuang, Z., Zhao, X., Lian, M., Wang, J., Ye, Y., Quan, L., Wu, H., Wang, K., Lai, L. (2020). ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems. BMC biology, 18(1), 131.
4. Li, N.*, Gou, S.*, Wang, J.*, Zhang, Q., Huang, X., Xie, J., Li, L., Jin, Q., Ouyang, Z., Chen, F., Ge, W., Shi, H., Liang, Y., Zhuang, Z., Zhao, X., Lian, M., Ye, Y., Quan, L., Wu, H., Lai, L., Wang, K. (2021). CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I. Molecular therapy : the journal of the American Society of Gene Therapy, 29(3), 1001–1015.
5. Wu H, Liu Q, Shi H, Xie J, Zhang Q, Ouyang Z, Li N, Yang Y, Liu Z, Zhao Y, Lai C, Ruan D, Peng J, Ge W, Chen F, Fan N, Jin Q, Liang Y, Lan T, Yang X, Wang X, Lei Z, Doevendans PA, Sluijter JPG, Wang K, Li X, Lai L. Engineering CRISPR/Cpf1 with tRNA promotes genome editing capability in mammalian systems[J]. Cell Molecular Life Science, 2018, 75(19):3593-3607.

1. 赖良学；王可品；葛维凯；刘琪帅；谢精科；一种重度免疫缺陷猪模型及其构建方法和应用，2019-2-25，中国，CN201910137229.2
2. 赖良学；王可品；梁艳慧；谢精科；一种融合蛋白及含有其的由双脱氨酶介导的碱基编辑系统和应用，2022-03-01，中国，CN202210193759.0

l 国家自然科学基金青年项目（1项，主持）
l 中国博士后科学基金面上项目（1项，主持）
l 海南省科技计划（三亚崖州湾科技城自然科学基金联合项目，1项，主持）
l 广州市科技计划项目（基础与应用基础研究项目，1项，主持）

技术咨询