生物医药

利用人多能干细胞获得治疗性血液及免疫细胞的策略研究（包括人多能干细胞体外造血分化调控及功能性血液/免疫细胞的获得、人多能干细胞异种嵌合相关研究）

1. Zhu Y#, Wang T#, Gu J#, Huang K, Zhang T, Zhang Z, Liu H, Tang J, Mai Y, Zhang Y, Li Y, Feng Y, Kang B, Li J, Shan Y, Chen Q, Zhang J, Long B, Wang J, Gao M, Zhang D, Zhou M, Zhong X, Chen J, Pei D, Nie J, Liu B, Pan G. Characterization and generation of human definitive multipotent hematopoietic stem/progenitor cells. Cell Discov. 2020 Dec 1;6(1):89.
2. Huang K#, Zhu Y#, Ma Y, Zhao B, Fan N, Li Y, Song H, Chu S, Ouyang Z, Zhang Q, Xing Q, Lai C, Li N, Zhang T, Gu J, Kang B, Shan Y, Lai K, Huang W, Mai Y, Wang Q, Li J, Lin A, Zhang Y, Zhong X, Liao B, Lai L, Chen J, Pei D, Pan G. BMI1 enables interspecies chimerism with human pluripotent stem cells. Nat Commun. 2018 Nov 7;9(1):4649.
3. Wang W#, Zhu Y#, Huang K, Shan Y, Du J, Dong X, Ma P, Wu P, Zhang J, Huang W, Zhang T, Liao B, Yao D, Pan G, Liu J. Suppressing P16Ink4a and P14ARF pathways overcomes apoptosis in individualized human embryonic stem cells.
4. Shan Y, Zhang Y, Zhao Y, Wang T, Zhang J, Yao J, Ma N, Liang Z, Huang W, Huang K, Zhang T, Su Z, Chen Q, Zhu Y, Wu C, Zhou T, Sun W, Wei Y, Zhang C, Li C, Su S, Liao B, Zhong M, Zhong X, Nie J, Pei D, Pan G. JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells. Nat Commun. 2020 Jan 20;11(1):382.
5. Zhang T, Huang K, Zhu Y, Wang T, Shan Y, Long B, Li Y, Chen Q, Wang P, Zhao S, Li D, Wu C, Kang B, Gu J, Mai Y, Wang Q, Li J, Zhang Y, Liang Z, Guo L, Wu F, Su S, Wang J, Gao M, Zhong X, Liao B, Chen J, Zhang X, Shu X, Pei D, Nie J, Pan G. Vitamin C-dependent lysine demethylase 6 (KDM6)-mediated demethylation promotes a chromatin state that supports the endothelial-to-hematopoietic transition. J Biol Chem. 2019 Sep 13;294(37):13657-13670.
6. Shan Y, Liang Z, Xing Q, Zhang T, Wang B, Tian S, Huang W, Zhang Y, Yao J, Zhu Y, Huang K, Liu Y, Wang X, Chen Q, Zhang J, Shang B, Li S, Shi X, Liao B, Zhang C, Lai K, Zhong X, Shu X, Wang J, Yao H, Chen J, Pei D, Pan G. PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not na？ve ESCs. Nat Commun. 2017 Sep 22;8(1):672.
7. Huang K, Gao J, Du J, Ma N, Zhu Y, Wu P, Zhang T, Wang W, Li Y, Chen Q, Hutchins AP, Yang Z, Zheng Y, Zhang J, Shan Y, Li X, Liao B, Liu J, Wang J, Liu B, Pan G. Generation and Analysis of GATA2w/eGFP Human ESCs Reveal ITGB3/CD61 as a Reliable Marker for Defining Hemogenic Endothelial Cells during Hematopoiesis. Stem Cell Reports. 2016 Nov 8;7(5):854-868.