生物医药

1）冠状病毒进入细胞过程中诱导膜融合机制探索；
2）膜融合特异性抑制药物/抗体的筛选

Ma, Y#., Li, P#., Hu, Y#., Qiu, T., Wang, L., Lu, H., Lv, K., Xu, M., Zhuang, J., Liu, X., He, S., He, B., Liu, L., Wang, Y., Yue, X., Zhai, Y., Luo, W., Mai, H., Kuang, Y., Chen, S., Ye, F., Zhou, N., Zhao, W., Chen, J., Chen, S., Xiong, X., Shi, M., Pan, J*., Chen, Y*. Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2. PLOS Pathogens. 2023 May 17, 19(5):e1011123.Liang, Y#., Ma, Y#., Zhang Y., Chen, Z., Wang Z., Li X., Cui, L., Xu, L., Liu, S*., Li, H*. Single-Cell Analysis of the In Vivo Dynamics of Host Circulating Immune Cells Highlights the Importance of Myeloid Cells in Avian Flaviviral Infection. Journal of Immunology, 2021, 207(11):2878-2891. Cui, L#., Ma, Y#., Liang, Y., Chen, Z., Wang, Z., Wu, H., Li, X., Xu, L., Liu, S*., Li, H*. Polarization of avian macrophages upon avian flavivirus infection. Veterinary Microbiology. 2021 May; 256:109044. Ma, Y., Liang, Y., Wang, N., Cui, L., Chen, Z., Wu, H., Zhu, C., Wang, Z., Liu, S*., Li, H*. Avian Flavivirus Infection of Monocytes/Macrophages by Extensive Subversion of Host Antiviral Innate Immune Responses. Journal of Virology. 2019, 93(22). pii: JVI.00978-19. Ma, Y., Sun, J., Gu, L., Bao, H., Zhao, Y., Shi, L., Yao, W., Tian, G., Wang, X*., Chen, H*. Annexin a2 (anxa2) interacts with nonstructural protein 1 and promotes the replication of highly pathogenic H5N1 avian influenza virus. BMC Microbiology, 2017, 17(1), 191. Yu, T#., Ling, Q#., Xu, M#., Wang, N#., Wang, L., Lin, H., Cao, M., Ma, Y., Wang, Y., Li, K., Du, L., Jin, Y., Li, Y., Guo, D., Peng, X*., Chen, Y*., Zhao, B*., Pan, J*. ORF8 protein of SARS-CoV-2 reduces male fertility in mice. Journal of Medical Virology, 2022; 1-13. doi:10.1002/jmv.27855He, B#., Liu, S#., Xu, M#., Hu,,Y., Lv, K., Wang, Y., Ma, Y., Zhai, Y., Yue, X., Liu, L., Lu, H., Zhou,S., Li, P., Mai, G., Huang, X., Li, C., Chen, S., Ye, S., Zhao, P., Yang, Y., Li, X., Jie, Y., Shi, M., Yang, J*., Shu, Y*., Chen, Y*., Comparative global B cell receptor repertoire difference induced by SARS-CoV-2 infection or vaccination via single-cell V(D)J sequencing. Emerging Microbe & Infections. 2022 Dec; 11(1):2007-2020. doi: 10.1080/22221751.2022.2105261.He, B#., Liu, S#., Wang, Y#., Xu, M., Cai, W., Liu, J., Bai, W., Ye, S., Ma, Y., Hu, H., Meng, H., Sun, T., Li, Y., Luo, H., Shi, M., Du, X., Zhao, W., Chen, S., Yang, J., Zhu, H., Jie, Y., Yang, Y., Guo, D., Wang, Q., Liu, Y., Yan, H., Wang, M., Chen, Y*. Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq. Signal Transduction and Targeted Therapy. 2021; 6(1):195. doi: 10.1038/s41392-021-00610-7. Li, M., Yin, X., Guan, L., Zhang, X., Deng, G., Li, T., Cui, P., Ma, Y., Hou, Y., Shi, J., Chen, H*. Insights from avian influenza surveillance of chickens and ducks before and after exposure to live poultry markets. Science China-Life sciences. 2019 Jun;62(6):854-857. Qiao, Y#., Wang, Z#., Han, Z., Shao, Y., Ma, Y., Liang, Y., Chen, Z., Wu, H., Cui, L., Zhang, Y., Liu, S*., Li, H*. Global exploration of the metabolic requirements of gallid alphaherpesvirus 1. PLOS Pathogens. 2020 Aug 24;16(8):e1008815.

1，国家自然科学基金委员会, 青年科学基金项目 （2021年）；项目负责人
2，深圳市高等院校稳定支持计划面上项目，（2021年）；项目负责人
3，国家自然科学基金委员会, 重大研究计划, （2022年）；项目核心骨干
4，呼吸疾病全国重点实验室自主课题, (2025年); 项目负责人