生物医药

生物医学大数据与生物信息学，计算机辅助药物设计，分子生物学

1. Yajie Guo; Linlin Zhao; Xiaoyi Zhang*; Hao Zhu. Using a New Hybrid Read-across Method to Evaluate Chemical Toxicity based on both Chemical and Biological Information. Ecotoxicology and Environmental Safety.2019. 30;178:178-187.
2. Tang Tang, Xiaoyan Du, Xiaoyi Zhang*, Wenling Niu, Chunhua Li & Jianjun Tan. Computational identification and analysis of early diagnostic biomarkers for kidney cancer. Journal of Human Genetics 2019 ( 64), 1015–1022.
3. Zhang X* , Niu W , Tang T , et al. A Strategy to Find Novel Candidate DKAs Inhibitors Using Modified QSAR Model with Favorable Druggability Properties[J]. Chemical Research in Chinese Universities, 2019, 35(6):1111-1118.
4. Xiaoyi Zhang*, Dongjie Deng, Jianjun Tan, Yu He, Chunhua Li, Cunxin Wang*, Pharmacophore and Docking-based 3D-QSAR Study for HIV-1 Integrase Inhibitors，chemical research in Chinese universities,2014,30(2),297-305.
5. HE HongQiu, LIU Bin, ZHANG XiaoYi, CHEN WeiZu, WANG CunXin, Development of a high-throughput assay for the HIV-1 integrase disintegration reaction, science China, 2010, 53: 241-247.
6. Hong-qiu HE, Xiao-hui MA, Bin LIU, Xiao-yi ZHANG, Wei-zu CHEN, Cun-xin WANG, Shao-hui Cheng, High-throughput real-time assay based on molecular beacons for HIV-1 integrase 3’-processing reaction，Acta Pharmacologica Sinica, 2007, 28 (6): 811-817.
7. Xiao-hui Ma, Xiao-yi Zhang, Jian-jun Tan, Wei-zu Chen, Cun-xin Wang, Exploring Binding Mode for Styrylquinoline HIV-1 Integrase Inhibitors Using Comparative Molecular Field Analysis and Docking Studies，Acta Pharmacological Sinica, 2004, 25 (7): 950-958．

主持的项目：
北京市属高等学校青年拔尖培育计划：整合酶二酮酸类抑制剂的耐药性预测，2015-2017
北京高等学校高水平人才交叉培养“实培计划”：早期肿瘤标志物的特征选择，2016
北京市教委面上项目：HIV-1耐药突变整合酶的耐药相关参数分析，2014-2016
北京市优秀人才：野生型和耐药突变型HIV整合酶双效抑制剂的分子设计，2013-2015
国家自然科学基金：HIV-1整合酶原发性耐药突变的耐药机理研究，2012-2014
北京工业大学博士科研启动基金：2011
北京工业大学校青年科研基金项目：2003

主要参加的项目：
1项中意国际合作项目，6项国家自然科学基金项目，4项北京市自然科学基金项目，2项北京市教委项目等