天然气化工,新材料,石油炼制,石油化工,精细化工,生物医药

催化剂创制与应用、基础化学品高值化、功能分子材料开发利用

Dearomatization;Palladium;Asymmetric Catalysis;Copper;Homogeneous Catalysis;C-h Activation;Amination;Spiroannulation;Self-assembly;Hydroxylamines

独立工作以后发表论文：
70. Jie Han,* Zhixiao Cheng, Xuan Du, Jingyun Ren, Zhiming Li,* Xinjun Luan,* Synthesis of Axially Chiral Allenes by Pd-Catalyzed Thianthrene-Mediated Functionalization of Alkynes with Arenes, Org. Lett. 2026, 28, 1300-1305.

69. Naichen Zhang,† Yuyang Chen,† Ganlu Qian,† Yicong Ge,* Dongwei Zhao, Long Liu, Lu Bai, Xin Hong,* Jingjing Liu,* Xinjun Luan,* Unifying Dearomatization and Rearomatization via Stereoselective Chlorination/Dechlorination: Resolution of Axially Chiral 1-Aryl-2-naphthols, J. Am. Chem. Soc. 2025, 147, 46384-46395.

68. Jiamao Hao, Yun Kam Mok, Xinjun Luan,* Zhongxing Huang,* Tri- and tetra-ortho-substituted biaryls via lithium cupratecatalyzed reductive desymmetrization of isophthaldehydes, J. Am. Chem. Soc. 2025, 147, 46, 42938-42948.

67. Dongwei Zhao,† Junjie Sun,† Ning Chen,† Yicong Ge, Jingjing Liu, Lu Bai,* Xinjun Luan,* "Catalytic Asymmetric P-Site Dearomatization Enables Kinetic Resolution", J. Am. Chem. Soc. 2025, 147, 23202-23212.

66. Jinrong Du, Jiale Li, Lebin Qian, Xinjun Luan,* Zhijun Zuo,* "Organophotoredox and Cobalt-catalyzed 1,2-Difunctionalization of Mono-Donor Cyclopropanes", Angew. Chem. Int. Ed. 2025, 64, e202515761.

65. Yong Xu,† Lifeng Wang,† Aohua Yang, Jingyun Ren*, Jingjing Liu*, Xinjun Luan,* Trifunctionalization of Iodoarenes via Sequence-Controlled Double Ortho C-H Acylations by Palladium/Norbornene Catalysis, Angew. Chem. Int. Ed. 2025, 64, e202424604.

64. Long Liu, Naichen Zhang, Yicong Ge,* Xinjun Luan,* Selectfluor-Mediated C(sp3)–S Bond Cleavage for the Synthesis of Aryl Sulfinate Esters, J. Org. Chem. 2025, 90, 18234-18243.

63. Haohao Huang, Xinjun Luan,* Zhijun Zuo,* Cooperative Photoredox and Cobalt-catalyzed Acceptorless Dehydrogenative Functionalization of Cyclopropylamides towards Allylic N,O-Acyl-acetal Derivatives, Angew. Chem. Int. Ed. 2024, 63, e202401579

62. Cheng Guo, Yufei Dong, Yiyang Wang, Xuan Du, Runxia Ma, Choon-Hong Tan,* Xinjun Luan,* Jingyun Ren,* Enantioselective Synthesis of Chiral Acyclic Nitriles Containing α-All-Carbon Quaternary Stereocenters via Synergistic Palladium and Phase-Transfer Catalysis, ACS Catal. 2024, 14, 18841-18850.

61. Linqiang Li, Dong Wang, Yue Zhang, Jingjing Liu, Han Wang, Xinjun Luan,* Diversification of Naphthol Skeletons Triggered by Aminative Dearomatization, Org. Lett. 2024, 26, 4910-4915.

60. Yu Sun, Na Zhang, Jingyun Ren, Haohao Huang, Xinjun Luan,* Zhijun Zuo,* Highly Selective 1,4-Diacylation/Cycloisomerization of 1,3-Enynes: De Novo Synthetic Strategy to Polysubstituted Furans, Org. Lett. 2024, 26, 35-40.

59. Sichan Dong, Changzhen Fu, Yicong Ge, Jingjing Liu, Han Wang, Xinjun Luan,* Dearomatization/Spiroannulation of Halophenols Enables the Forging of Contiguous Quaternary Carbon Cyclohexadienones, Org. Lett. 2023, 25, 7841-7846.

58. Lingbo Han, Xin Wei, Yi Yuan, Lu Bai, Hui Wang, Xinjun Luan,* Palladium-Catalyzed C-H Arylation/Arene Dearomatization Domino Reaction: Expeditious Access to Spiro[4,5]fluorenes, Org. Lett. 2023, 25, 5619-5623.

57. Lingbo Han, Tingjie Liu, Han Wang, Xinjun Luan,* Palladium-Catalyzed Alkenyl C-H Activation/Diamination toward Tetrahydrocarbazole and Analogs Using Hydroxylamines as Single-Nitrogen Sources, Org. Lett. 2023, 25, 58-63.

56. Mian Qi; Mengyao Li; Lu Bai; Jingjing Liu; Xinjun Luan; Rapid Assembly of Spiroisoxazolidines by [4+1] Dearomative Spiroannulation of α-Bromo-β-naphthol and Nitroolefin, J. Org. Chem. 2023, 88, 5997-6007.

55. Dongwei Zhao, Mengtian Liu, Lu Bai,* Jingjing Liu, Xinjun Luan,* Rapid Assembly of Spironaphthalenones by Dearomative Spiroannulation of Naphthols and Dielectrophiles, J. Org. Chem. 2023, 88, 15913-15924.

54. Xiaobing Huang, Jingxun Yu, Xinjun Luan,* [3+2] Cycloaddition of Vinyl Cyclopropane and Hydroxylamines via Isocynate Intermediate to -Lactams, Chin. J. Chem. 2023, 41, 1937-1942.

53. Jiaoyu Wu,† Linqiang Li,† Mengtian Liu, Lu Bai,* Xinjun Luan,* "Selective C(sp3)-N Bond Cleavage of N,N-Dialkyl Tertiary Amines with the Loss of a Large Alkyl Group via an SN1 Pathway", Angew. Chem. Int. Ed. 2022, 61, e202113820.

52. Lu Bai,† Xin Luo,† Yicong Ge, Hui Wang, Jingjing Liu*, Yaoyu Wang, Xinjun Luan*, "Catalytic Asymmetric [4+1] Spiroannulation of α-Bromo-β-Naphthols with Azoalkenes by an Electrophilic Dearomatization/SRN1-Debromination Approach", CCS Chem. 2022, 4, 1054-1064.

51. Pin Ding†, Lingbo Han†, Jiaxing Bai†, Jingjing Liu,* Xinjun Luan,* "Fine-Tuning Hydroxylamines as Single-Nitrogen Sources for Pd(0)-Catalyzed Diamination of o-Bromo(or Chloro)-biaryls", Sci. China Chem. 2022, 65, 686-693.

50. Jiaxing Bai, Nengni Xu, Hui Wang, Xinjun Luan* "Palladium(II)-Catalyzed [2+2+1] Annulation of Alkynes and Hydroxylamines: A Rodox-Neutral Approach to Fully Substituted Pyrroles", Org. Lett. 2022, 24, 5099-5104.

49. Jing Wang,† Linqiang Li,† Zihan Wang, Jingjing Liu,* Xinjun Luan,* "Trifunctionalization of aryl iodides via intermolecular C-H acylation/intramolecular C-H alkylation by using palladium/norbornene cooperative catalysis", Org. Chem. Front. 2022, 9, 4003-4008.

48. Bigui Zhou,† Zhiwei Yuan,† Jingxun Yu, Xinjun Luan,* "Dearomatization/Deiodination of o-Iodophenolic Compounds with α,β-Unsaturated Imines for Accessing Benzofuran Derivatives", Org. Lett. 2022, 24, 837−841.

47. Naichen Zhang,† Yuanzhi Ye,† Lu Bai, Jingjing Liu, Han Wang, Xinjun Luan,* "Transition metal-free dearomatization of halonaphthols with C(sp3)-electrophiles", Chin. Chem. Lett. 2022, 33, 2411–2414.

46. Ping Zhao,† Yun Guo,† Xinjun Luan,* "Total Synthesis of Dalesconol A by Pd(0)/Norbornene-Catalyzed Three-Fold Domino Reaction and Pd(II)-Catalyzed Trihydroxylation", J. Am. Chem. Soc. 2021, 143, 21270–21274.

45. Jing Wang, Hui Wang, Zihan Wang, Linqiang Li, Cheng Qin, and Xinjun Luan*, "Trifunctionalization of Aryl Iodides with Two Distinct Nitrogen and Carbon Electrophiles by Palladium/Norbornene Catalysis", Chin. J. Chem. 2021, 39, 2659-2667. (Breaking Report)

44. Xiumei Liu, Wenhua Xu, Fang Fang, Nengni Xu, Zhishuang Lin, Xinjun Luan, Jinfeng Zhang*, Hui Wang,* "Construction of Structurally Rigid Azulen-6-ones via Migratory Rearrangement of Spirocycles and Their Photophysical Studies", Org. Lett. 2021, 23, 8662-8667.

43. Jiamao Hao, Yicong Ge, Liuqing Yang, Jing Wang, Xinjun Luan,* "Highly Regioselective Ru(II)-Catalyzed [3+2] Spiroannulation of 1-Aryl-2-Naphthols with Alkynes via a Double Directing Group Strategy", Tetrahedron Lett. 2021, 71, 153050. (In honor of Professor Guangbin Dong for the 2021 Tetrahedron Young Investigator Award in Organic Synthesis)

42. Sichan Dong, Xinjun Luan,* "Catellani Reaction: An Enabling Technology for Vicinal Functionalization of Aryl Halides by Palladium(0)/Norbornene Cooperative Catalysis", Chin. J. Chem. 2021, 39, 1690-1705. (Cornerstones in Chemistry)

41. Huayu Zheng, Yicong Ge, Xinjun Luan,* "曼尼希型去芳构螺环化反应", 分子科学学报 2021, 37, 63. (Invited contribution)

40. Jingxun Yu, Xinjun Luan,* "Hydroxylamines as One-Atom Nitrogen Sources for Metal-Catalyzed Cycloadditions", Synthesis 2021, 53, 1423. (Invited review)

39. Tianyou Luo, Zhishuang Lin, Zhiyi Li, Ying Wang, Wenhua Xu, Chunxin Zhao, Hui Wang,* Xinjun Luan,* "Malononitrile based ternary AIE-ML materials: Experimental proof for emission switch from non-TADF to TADF", Org. Electron. 2021, 88, 106003.

38. Jiaoyu Wu, Lu Bai,* Lingbo Han, Jingjing Liu, Xinjun Luan,* "A chemo- and regioselective Pd(0)-catalyzed three-component spiroannulation", Chem. Commun. 2021, 51, 1117.

37. Jing Wang,† Cheng Qin,† Jean-Philip Lumb,* Xinjun Luan,* "Regioselective Synthesis of Polyfunctional Arenes by a 4-Component Catellani Reaction", Chem 2020, 6, 2097.

36. Liangxin Fan,† Jiamao Hao,† Jingxun Yu, Xiaojun Ma, Jingjing Liu, Xinjun Luan,* "Hydroxylamines as Bifunctional Single-Nitrogen Sources for the Rapid Assembly of Diverse Tricyclic Indole Scaffolds", J. Am. Chem. Soc. 2020, 142, 6698.

35. Yicong Ge,† Cheng Qin,† Lu Bai, Jiamao Hao, Jingjing Liu,* Xinjun Luan,* "A Dearomatization/Debromination Strategy for the [4+1] Spiroannulation of Bromophenols with α,β-Unsaturated Imines", Angew. Chem. Int. Ed. 2020, 59, 18985.

34. Zhijun Zuo,† Jing Wang,† Jingjing Liu,* Yaoyu Wang, Xinjun Luan,* "Palladium-Catalyzed [2+2+1] Spiroannulation via Alkyne-Directed Remote C−H Arylation and Subsequent Arene Dearomatization", Angew. Chem. Int. Ed. 2020, 59, 653.

33. Bojun Tan,† Long Liu,† Huayu Zheng, Tianyi Cheng, Dianhu Zhu, Xiaofeng Yang, Xinjun Luan,* "Two-in-One Strategy for Fluorene-Based Spirocycles via Pd(0)-Catalyzed Spiroannulation of o-Iodobiaryls with Bromonaphthols", Chem. Sci. 2020, 11, 10198.

32. Bojun Tan,† Lu Bai,† Pin Ding, Jingjing Liu, Yaoyu Wang, Xinjun Luan,* "Palladium-Catalyzed Intermolecular [4+1] Spiroannulation via C(sp3)–H Activation and Naphthol Dearomatization", Angew. Chem. Int. Ed. 2019, 58, 1474.

31. Lu Bai,† Jingjing Liu,† Wenjie Hu, Kunyu Li, Yaoyu Wang, Xinjun Luan,* "Palladium/Norbornene-Catalyzed C−H Alkylation/Alkyne Insertion/Indole Dearomatization Domino Reaction: Assembly of Spiroindolenine-Containing Pentacyclic Frameworks", Angew. Chem. Int. Ed. 2018, 57, 5151.

30. Zhijun Zuo, Hui Wang, Yunxia Diao, Yicong Ge, Jingjing Liu, and Xinjun Luan* "Palladium-Catalyzed Aryne Insertion/Arene Dearomatization Domino Reaction: A Highly Chemoselective Route to Spirofluorenes", ACS Catal. 2018, 8, 11029.

29. Jiang Nan, Yini Yuan, Lu Bai, Jingjing Liu, and Xinjun Luan* "Highly Chemoselective Construction of Spiro[4,5]decane-Embedded Polycyclic Scaffolds by a Palladium/Norbornene-Catalyzed C-H Activation/Arene Dearomatization Reaction", Org. Lett. 2018, 20, 7731.

28. Wenjie Hu, Hui Wang, Lu Bai, Jingjing Liu, Xinjun Luan,* "Pd(0)-Catalyzed Intermolecular Dearomatizing [3 + 2] Spiroannulation of Phenol-Based Biaryls and Allenes", Org. Lett. 2018, 20, 880.

27. Jingjing Liu, Xin Yang, Zhijun Zuo, Jiang Nan, Yaoyu Wang, Xinjun Luan,* "Catalytic Enantioselective Tautomerization of Metastable Enamines", Org. Lett. 2018, 20, 244.

26. Hui Wang, Yanwei Liu, Wenjie Hu, Wenhua Xu, Pengfei Wang, Ying Wang,* Xinjun Luan,* "Novel spironaphthalenone-based host materials for efficient red Phosphorescent and thermally activated delayed fluorescent OLEDs", Org. Electron. 2018, 61, 376.

25. Lingbo Han, Hui Wang, Xinjun Luan,* "Pd(II)-Catalyzed [3+2] Spiroannulation of alpha-Aryl-belta-naphthols with Alkynes via a C-H Activation/Dearomatization Approach", Org. Chem. Front. 2018, 5, 2453.

24. Liangxin Fan,† Jingjing Liu,† Lu Bai, Yaoyu Wang, Xinjun Luan,* "Rapid Assembly of Diversely Functionalized Spiroindenes by a Three-Component Palladium-Catalyzed C-H Amination/Phenol Dearomatization Domino Reaction", Angew. Chem. Int. Ed. 2017, 56, 14257.

23. Zhijun Zuo, Hui Wang, Liangxin Fan, Jingjing Liu, Yaoyu Wang, Xinjun Luan,* "Modular Assembly of Spirocarbocyclic Scaffolds through Pd0-Catalyzed Intermolecular Dearomatizing [2+2+1] Annulation of Bromonaphthols with Aryl Iodides and Alkynes", Angew. Chem. Int. Ed. 2017, 56, 2767.

22. Lu Bai, Yan Wang, Yicong Ge, Jingjing Liu, Xinjun Luan,* "Diastereoselective Synthesis of Dibenzo[b,d]azepines by Pd(II)-Catalyzed [5 + 2] Annulation of o-Arylanilines with Dienes", Org. Lett. 2017, 19, 1734.

21. Yunxia Diao, Zhijun Zuo, Hui Wang, Jingjing Liu,* Xinjun Luan,* "Palladium(0)-catalyzed [2+2+1] cyclization of 1,6-enynes with vinyl bromides: a highly diastereoselective synthesis of terahydro-1H-cyclopenta[c]furans bearing two quaternary carbon centers", Org. Biomol. Chem. 2017, 15, 4601.

20. Lu Bai,† Yini Yuan,† Jingjing Liu, Jiaoyu Wu, Lingbo Han, Hui Wang, Yaoyu Wang, Xinjun Luan,* "Palladium(0)-Catalyzed Intermolecular Carbocyclization of (1,n)-Diynes and Bromophenols: An Efficient Route to Tricyclic Scaffolds", Angew. Chem. Int. Ed. 2016, 55, 6946.

19. Lei Luo, Huayu Zheng, Jingjing Liu, Hui Wang, Yaoyu Wang, Xinjun Luan,* "Highly Chemo- and Regioselective Construction of Spirocarbocycles by a Pd(0)-Catalyzed Dearomatization of Phenol-Based Biaryls with 1,3-Dienes", Org. Lett. 2016, 18, 2082.

18. Hui Wang, Xinjun Luan,* "Rapid assembly of spirocycles with phenol-derived biaryls with alkynes using an oxidative C–H activation/dearomatization strategy", Org. Biomol. Chem. 2016, 14, 9451.

17. Liu Yang,† Huayu Zheng,† Lei Luo,† Jiang Nan, Jingjing Liu, Yaoyu Wang, Xinjun Luan,* "Palladium-Catalyzed Dynamic Kinetic Asymmetric Transformation of Racemic Biaryls: Axial-to-Central Chirality Transfer", J. Am. Chem. Soc. 2015, 137, 4876.

16. Zhijun Zuo, Jingjing Liu, Jiang Nan, Liangxin Fan, Wei Sun, Yaoyu Wang, Xinjun Luan,* "Highly Stereoselective Synthesis of Imine-Containing Dibenzo[b,d]azepines by a Palladium(II)-Catalyzed [5+2] Oxidative Annulation of o-Arylanilines with Alkynes", Angew. Chem. Int. Ed. 2015, 54, 15385.

15. Jiang Nan, Jingjing Liu, Huayu Zheng, Zhijun Zuo, Lei Hou, Huaiming Hu, Yaoyu Wang, Xinjun Luan,* "Direct Asymmetric Dearomatization of 2-Naphthols by Scandium-Catalyzed Electrophilic Amination", Angew. Chem. Int. Ed. 2015, 54, 2356.

14. Huayu Zheng, Lu Bai, Jingjing Liu, Jiang Nan, Zhijun Zuo, Liu Yang, Yaoyu Wang, Xinjun Luan,* "Pd(0)-Catalyzed Chemoselective Construction of Spirocarbocycles via an Alkyne Insertion/β-Naphthol Dearomatization Cascade", Chem. Commun. 2015, 51, 3061.

13. Zhijun Zuo, Xin Yang, Jingjing Liu, Jiang Nan, Lu Bai, Yaoyu Wang, Xinjun Luan,* "Ru(II)-Catalyzed Oxidative Spiroannulation of 2‑Arylphenols with Alkynes via a C−H Activation/Dearomatization Strategy", J. Org. Chem. 2015, 80, 3349.

12. Songlin Gu, Lei Luo, Jingjing Liu, Lu Bai, Huayu Zheng, Yaoyu Wang, Xinjun Luan,* "Palladium(II)-Catalyzed Oxidative Dearomatization of Free Naph-thols with Two Alkyne Units", Org. Lett. 2014, 16, 6132.

11. Yini Yuan,, Lu Bai, Jiang Nan, Jingjing Liu,* Xinjun Luan, "Regiospecific Ficini [2 + 2] Cycloaddition of Ynamides with Cyclic Isoimidium Salts under Catalyst-Free Conditions", Org. Lett. 2014, 16, 4316.

10. Jiang Nan,† Zhijun Zuo,† Lei Luo, Lu Bai, Huayu Zheng, Yini Yuan, Jingjing Liu, Xinjun Luan,* Yaoyu Wang, "RuII-Catalyzed Vinylative Dearomatization of Naphthols via a C(sp2)-H Bond Activation Approach", J. Am. Chem. Soc. 2013, 135, 17306.

博士后阶段代表性论文：
9. Barry M. Trost,* Xinjun Luan, "Synthesis of α-Allylated α,β-Unsaturated Carbonyl Compounds Using Vanadium/Palladium Contemporaneous Dual Catalysis", Nat. Protoc. 2012, 7, 1497-1501.

8. Barry M. Trost,* Xinjun Luan, “Contemporaneous Dual Catalysis by Coupling Highly Transient Nucleophilic and Electrophilic Intermediates Generated In Situ”, J. Am. Chem. Soc. 2011, 133, 1706-1709.

7. Barry M. Trost,* Xinjun Luan, Yan Miller, “Contemporaneous Dual Catalysis: Chemoselective Cross-Coupling of Catalytic Vanadium-allenoate and π-Allylpalladium Intermediates”, J. Am. Chem. Soc. 2011, 133, 12824-12833.

博士阶段代表性论文：
6. Luan, X.; Mariz, R.; Gatti, M.; Costabile, C.; Poater, A.; Cavallo, L.; Linden, A.; Dorta, R.* “Identification and Characterization of a New Family of Catalytically Highly Active Imidazolin-2-ylidenes”, J. Am. Chem. Soc. 2008, 130, 6848-6858.

5. Luan, X.; Wu, L.; Drinkel, E.; Mariz, R.; Gatti, M.; Dorta, R.* “Highly Chemo- and Enantioselective Synthesis of 3-Allyl-3-Aryl Oxindoles via the Direct Palladium-Catalyzed Intramolecular α-Arylation of Amides”, Org. Lett. 2010, 12, 1912-1915.

4. Luan, X.; Mariz, R.; Robert, C.; Gatti, M.; Blumentritt, S.; Linden, A.; Dorta, R.* “Matching the Chirality of Monodentate N-Heterocyclic Carbene Ligands; A Case Study on Well-Defined Palladium Complexes for Asymmetric α-Arylations of Amides.”, Org. Lett. 2008, 10, 5569-5572.

硕士阶段代表性论文：
3. Luan, X.; Cai, X.; Wang, Y.*; Li, D.; Wang, C.; Liu, P.; Hu, H.; Shi, Q.; Peng, S. “An Investigation of the Self-Assembly of Neutral, Interlaced, Triple-Stranded Molecular Braids", Chem. Eur. J. 2006, 12, 6281-6289.

2. Luan, X.; Chu, Y.; Wang, Y.*; Li, D.; Liu, P.; Shi, Q. "Formation of Two-Dimensional Supramolecular Water Layer Containing (H2O)18 Morphology via Dianion Templating", Cryst. Growth Des. 2006, 6, 812-814.

1. Luan, X.; Wang, Y.*; Li, D.; Liu, P.; Hu, H.; Shi, Q.; Peng, S. "Self-Assembly of an Interlaced Triple-Stranded Molecular Braid with an Unprecedented Topology through Hydrogen-Bonding Interactions", Angew. Chem. Int. Ed. 2005, 44, 3864-3867.
(* 通讯作者；† 共同第一作者)

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