生物医药

工业微生物细胞工厂构建、发酵过程多尺度强化

[1]Zhang Chuanbo#, Chen Chen#, Bian Xueke#, Zhang Jiale, Zhang, Zhanwei, Ma, Yuanyuan*, Wenyu Lu*. Construction an orthogonal transport system for Saccharomyces cerevisiae peroxisome to efficiently produce sesquiterpene[J]. Metabolic Engineering, 2024, 85:84-93.
[2]Zhang Chuanbo, Liu Jingjing, Zhao Fanglong, Lu Chunzhe, Zhao Guang-Rong, Lu Wenyu*. Production of sesquiterpenoid zerumbone from metabolic engineered Saccharomyces cerevisiae[J]. Metabolic Engineering, 2018, 49: 28-35.
[3]Zhang Wanze, Zhang Jiale, Zhao Xiaomeng, Zhang Zhanwei, He Shifan, Bian Xueke, Wang Haibin, Zhang Chuanbo*, Lu Wenyu*. Efficient production of ginsenoside Rh2 from xylose by remodeling metabolism in Saccharomyces cerevisiae[J]. Chemical Engineering Journal, 2024, 494:1-13.
[4]Ge Weiwei, Zhang Jiale, Zhang Chuanbo*, Lu Wenyu*. Construction of isopentenol utilization pathway and artificial multifunctional enzyme for miltiradiene synthesis in Saccharomyces cerevisiae[J]. Bioresource Technology, 2025, 419: 1-11.
[5]Fu Xiaomeng, Zuo Xiaoru, Zhang Chuanbo*, Lu Wenyu*. Heterologous Production of Levopimaradiene in Saccharomyces cerevisiae[J]. ACS Synthetic Biology, 2025, 14(7): 2657-2666
[6]Fu, Xiaomeng, Zuo Xiaoru, Zhao Xiaomeng, Zhang Huizhi, Zhang Chuanbo*, Lu Wenyu*. Characterization and designing of an SAM riboswitch to establish a high-throughput screening platform for SAM overproduction in Saccharomyces cerevisiae[J]. Biotechnology and Bioengineering, 2023, 120(12): 3622-3637.
[7]Zhao Fanglong, Zhang Chuanbo, Nan Weihua, Lu Wenyu*. An integrated bioprocess for fermentative production of protopanaxadiol by recycling ethanol waste during down-stream extraction process[J]. Journal of Cleaner Production, 2019, 234: 1-8.
[8]Fu Xiaomeng, Hong Kunqiang, Wang Haibin, Zhang Chuanbo*, Lu Wenyu*. Screening and remodeling of enone oxidoreductase for high production of 2(or 5)-Ethyl-5(or 2)-methyl-4-hydroxy-3(2H)-Furanone in Saccharomyces Cerevisiae[J]. Journal of Agricultural and Food Chemistry, 2022, 70(32): 9888-9897.
[9]Zhao Fanglong, Bai Peng, Liu Ting, Li Dashuai, Zhang Xiangmei, Lu Wenyu*, Yuan Yingjin. Optimization of a cytochrome P450 oxidation system for enhancing protopanaxadiol production in Saccharomyces cerevisiae[J]. Biotechnology and bioengineering, 2016, 113(8): 1787-1795.
[10]Ye Nan, Du Jiaxin, Bian Xueke, Zhao Xiaomeng, Zhang Chuanbo*, Lu Wenyu*. Heterologous synthesis of ginsenoside F2 in Saccharomyces cerevisiae by pathway and UDP-glycosyltransferase engineering[J]. Chemical Engineering Science, 2023, 278: 1-8.

[1]卢文玉, 赵方龙.能提高达玛烯二醇转化效率的融合蛋白质及构建方法[P]. 中国发明专利, 授权专利号: ZL201410736994.3
[2]卢文玉, 赵方龙. 一种能提高达玛烯二醇转化效率的融合蛋白质及构建方法及应用[P]. 中国发明专利, 授权专利号: ZL201410735927.X
[3]卢文玉, 李大帅, 张强, 赵方龙. 合成达玛烯二醇的大肠杆菌基因工程菌株及构建方法[P]. 中国发明专利, 授权专利号: ZL201510672700.X
[4]卢文玉, 张亚光, 杨雪. 一种槐糖脂发酵生物分离系统及方法[P]. 中国发明专利, 授权专利号: ZL201610343815.9
[5]卢文玉, 林福建, 郭校燕. 一种转化人参皂苷Rb1生产Rd的曲霉及应用[P]. 中国发明专利, 授权专利号: ZL201510543267.x
[6]卢文玉, 可迪. 异源合成龙涎香醇的重组大肠杆菌及其构建方法[P]. 中国发明专利, 授权专利号: ZL201711111081.2
[7]卢文玉, 高晓. 利用木糖生产达玛烯二醇和原人参二醇的重组酿酒酵母菌及构建方法[P]. 中国发明专利, 授权专利号: ZL 201810781608.0
[8]卢文玉, 张传波, 陆春哲. 生产熊果酸和齐墩果酸的重组酵母菌及其构建方法和应用[P]. 中国发明专利, 授权专利号: ZL202010075904.6
[9]卢文玉, 鞠海燕, 刘婷, 张传波. 生产龙涎香醇的重组酿酒酵母菌及构建方法[P]. 中国发明专利, 授权专利号: ZL202010113440.3
[10]卢文玉, 张传波, 叶楠, 田锦平. 异源合成人参皂苷F2的重组酿酒酵母及其构建方法[P]. 中国发明专利, 授权专利号: ZL202111364221.3
[11]卢文玉, 张传波, 魏盼盼, 牌慧慧. 异源合成鼠尾草酸的重组酿酒酵母及构建方法[P]. 中国发明专利, 授权专利号: ZL 202111364217.7
[12]卢文玉, 张传波, 田锦平, 刘瑞霞. 代谢甘油生产人参皂苷CK的重组酿酒酵母菌及构建方法[P]. 中国发明专利, 授权专利号: ZL 202210519519.5
[13]卢文玉, 张传波, 鞠海燕. 生产毛喉素的重组酿酒酵母菌及构建方法[P]. 中国发明专利, 授权专利号: ZL202111364198.8
[14]卢文玉, 尹静, 张传波. 生物反应器[P]. 中国实用新型专利, 授权专利号: ZL201420684713.X
[15]卢文玉, 王晓阳, 张传波. 刺糖多孢菌基因组尺度代谢网络模型及构建方法及应用[P]. 中国发明专利, 授权专利号: ZL201310756418.0
[16]卢文玉, 王美玲, 赵方龙, 尹静. 一种多杀菌素的发酵方法[P]. 中国发明专利, 授权专利号: ZL201310756416.1
[17]卢文玉, 薛朝友, 张香梅. 能提高多杀菌素产量的基因工程菌及构建方法及应用[P]. 中国发明专利, 授权专利号: ZL201310756049.5
[18]卢文玉, 赵方龙. 能提高达玛烯二醇转化效率的融合蛋白质及构建方法及应用[P]. 中国发明专利, 授权专利号: ZL201410734624.6
[19]卢文玉, 张传波, 付肖蒙，王海滨. 生产虫草素的重组酵母及构建方法及应用[P]. 中国发明专利, 授权专利号: ZL202211065594.5

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