生物医药

DNA纳米技术、生命分析、合成生物学

Dna Nanotechnology;Dna Hydrogel;Rolling Circle Amplification;Photodynamic Therapy;Drug Delivery;Upconversion;Exosomes;Gene Therapy;Hydrogel;Self-assembly

《核酸功能材料》《合成基因组学》

1. Yanfei Guo+, Yan Huang+, Siqi Li, Dayong Yang*, Chi Yao*, Programmable DNA nanostructures for hTERT compartmentalization and translocation in living cells, Angewandte Chemie International Edition, 2026, DOI: 10.1002/anie.202525891.
2. Nachuan Song+, Hongjin Li+, Ruoyu Tao, Yan Huang, Rui Zhang, Jianfeng Guo*, Peifeng Liu*, Chi Yao*, Dayong Yang*, A smart DNA nanoframework enables synergistic photodynamic therapy of pancreatic cancer. Advanced Materials, 2025, DOI: 10.1002/adma.202416161.
3. Huaixin Zhao+*, Lijun Wang+, Sen Yang+, Zhuiyun Li+, Xiaocui Guo, Chen Zuo, Guoming Xie, Chi Yao*, Dayong Yang*, Smart energy-storing DNA hydrogel for on-demand laser-free photoimmunotherapy of melanoma. Journal of the American Chemical Society, 2025, DOI: 10.1021/jacs.5c06905.
4. Zhaoyue Lv, Peiran Li, Mingxing Liu, Chi Yao*, Dayong Yang*，Hybridization chain reaction-based DNA nanoframeworks for biosensing and therapeutic applications. Nature Protocols, 2025, DOI: 10.1038/s41596-025-01183-3.
5. Nachuan Song+, Ruoyu Tao+, Hongjin Li, Rui Zhang, Yan Huang, Le Zhang, Ying Liu*, Dayong Yang*, Chi Yao*, Spatially controlled co-delivery of diagnostic and therapeutic agents using DNA nanoframeworks for pancreatic cancer precision therapy. Angewandte Chemie International Edition, 2025, DOI: 10.1002/anie.202500566.
6. Sen Yang+, Junlin Wu+, Zhongyu Wang, Yu Cheng, Rui Zhang, Chi Yao*, Dayong Yang*, A smart DNA hydrogel enables synergistic immunotherapy and photodynamic therapy of melanoma. Angewandte Chemie International Edition, 2024, 136, e202319073.
7. Nachuan Song+, Hongjin Li+, Chi Yao*, Dayong Yang*, Dynamic chemistry of DNA-Based Nanoassemblies in Living Cells. Accounts of Chemical Research, 2024, 57, 2763.
8. Nachuan Song+, Xiaoting Fan+, Xiaocui Guo+, Jianpu Tang, Hongjin Li, Ruoyu Tao, Fengqin Li, Junru Li, Dayong Yang*, Chi Yao*, Peifeng Liu*, A DNA/upconversion nanoparticle complex enables controlled co-delivery of CRISPR-Cas9 and photodynamic agents for synergistic cancer therapy. Advanced Materials, 2024, 36, 2309534.
9. Jianpu Tang+, Xuemei Jia+, Qian Li+, Zhen Cui, Aiqi Liang, Bin Ke, Dayong Yang*, Chi Yao*, A DNA-based hydrogel for exosome separation and biomedical applications. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120, e2303822120.
10. Nachuan Song+, Yiwen Chu+, Shuai Li, Yuhang Dong, Xiaoting Fan, Jianpu Tang, Yanfei Guo, Guangshuai Teng, Chi Yao*, Dayong Yang*, Cascade dynamic assembly/disassembly of DNA nanoframework enabling the controlled delivery of CRISPR-Cas9 system. Science Advances, 2023, 9, eadi3602.
11. Yanfei Guo, Siqi Li, Zhaobin Tong, Jianpu Tang, Rui Zhang, Zhaoyue Lv, Nachuan Song, Dayong Yang*, Chi Yao*, Telomerase-mediated self-assembly of DNA network in cancer cells enabling mitochondrial interference. Journal of the American Chemical Society, 2023, 145, 23859.
12. Zhaoyue Lv+, Mengxue Huang+, Jing Yang+, Peiran Li, Lele Chang, Qianyun Tang, Xiaojing Chen, Shengqi Wang*, Chi Yao*, Peifeng Liu*, Dayong Yang*, A smart DNA-based nanosystem containing ribosome-regulating siRNA for enhanced mRNA transfection. Advanced Materials, 2023, 2300823.
13. Chi Yao+*, Yuwei Xu+, Jianpu Tang+, Pin Hu, Hedong Qi, Dayong Yang*, Dynamic assembly of DNA-ceria nanocomplex in living cells generates artificial peroxisome. Nature Communications, 2022, 13, 7739.
14. Chi Yao+, Hedong Qi+, Xuemei Jia, Yuwei Xu, Zhaobin Tong, Zi Gu, Dayong Yang*, A DNA nanocomplex containing cascade DNAzymes and promoter-like Zn-Mn-Ferrite for combined gene/chemo-dynamic therapy. Angewandte Chemie International Edition, 2022, 61, e202113619.
15. Chi Yao+, Junhan Ou+, Jianpu Tang+, Dayong Yang*, DNA supramolecular assembly on micro/nanointerfaces for bioanalysis. Accounts of Chemical Research, 2022, 15, 2043.
16. Chi Yao+, Rui Zhang+, Jianpu Tang, Dayong Yang*, Rolling circle amplification (RCA)-based DNA hydrogel. Nature Protocols, 2021, 16, 5460.
17. Chi Yao+, Chenxu Zhu+, Jianpu Tang, Junhan Ou, Rui Zhang, Dayong Yang*, T lymphocyte-captured DNA network for localized immunotherapy. Journal of the American Chemical Society, 2021, 143, 19330.
18. Chi Yao+, Han Tang+, Weijian Wu, Jianpu Tang, Weiwei Guo, Dan Luo, Dayong Yang*, Double rolling circle amplification generates physically crosslinked DNA network for stem cell fishing. Journal of the American Chemical Society, 2020, 142, 3422.

1. 一种DNA错配修复蛋白的制备方法
天津大学
仰大勇; 姚池; 谭维; 贾雪梅; 李帅
公开日期: 2024-12-13 申请日期: 2024-08-23 公开号: CN119120334A

2. 一种长单链DNA及其制备方法和应用
天津大学
仰大勇; 姚池; 谭维; 贾雪梅; 李帅
公开日期: 2024-11-22 申请日期: 2024-08-23 公开号: CN118995859A

3. 一种固定化的核酸错配识别蛋白及其固定方法和应用
天津大学
仰大勇; 姚池; 谭维; 贾雪梅; 李帅
公开日期: 2024-11-19 申请日期: 2024-08-23 公开号: CN118978601A

4. 人工核酸酶及其制备方法、检测方法
天津大学
仰大勇; 姚池; 李帅; 谭维
公开日期: 2024-08-16 申请日期: 2024-04-02 公开号: CN118491503A

5. DNA水凝胶双靶点免疫抑制剂及其制备方法和应用
天津大学浙江研究院
仰大勇; 贾雪梅; 姚池; 谭维; 李帅
公开日期: 2024-03-22 申请日期: 2023-12-20 公开号: CN117731684A

6. 基于枝状DNA的靶标触发信号级联放大的核酸检测方法
天津大学
仰大勇; 董宇航; 姚池
公开日期: 2022-12-09 申请日期: 2019-07-25 公开号: CN110452963B

7. 一种双滚环扩增脱氧核糖核酸水凝胶及其制备方法
天津大学
姚池; 唐涵; 仰大勇
公开日期: 2022-12-02 申请日期: 2019-07-23 公开号: CN110423743B

8. DNA网络水凝胶、制备方法及其组合物
天津大学浙江研究院
仰大勇; 郭蕴华; 姚池
公开日期: 2022-03-01 申请日期: 2021-11-25 公开号: CN114107198A

9. DNA水凝胶、制备方法、水凝胶组合物及其应用
天津大学浙江研究院
仰大勇; 姚池; 贾雪梅
公开日期: 2022-02-01 申请日期: 2021-11-03 公开号: CN113999842A

10. 一种上转换DNA纳米凝胶及制备方法及用途
天津大学
姚池; 仰大勇; 唐建普
公开日期: 2020-04-24 申请日期: 2019-12-02 公开号: CN111053733A

11. 抑制多药耐药乳腺癌生长的纳米给药系统及其制备方法和应用
复旦大学
黎占亭; 田佳; 姚池; 张丹维
公开日期: 2016-08-31 申请日期: 2016-06-03 公开号: CN105902498A

国家优秀青年科学基金项目
国家自然科学基金面上项目
国家自然科学基金青年项目
国家重点研发计划项目
天津市自然基金项目

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