生物医药

合成生物学、人工细胞工厂

VEGF;胎盘;CXCL12

Graphene;Metal-organic Frameworks;Electrocatalytic Nitrate Reduction;Adsorption;Energy Consumption;Electrocatalysis;Atomic Hydrogen;Graphene Oxide;Fenton-like Process;Reaction Kinetics

提出了重塑底盘菌株内源代谢的新方法，建立了高产萜烯类物质的普适性平台，实现高产二氢青蒿酸、虾青素、藏红花酸等高附加值萜烯类产品。
萜烯类分子及其衍生物具有重要的生理活性，其生产菌种研发周期制约于缺少普适性的底盘菌株。提出了碱基突变结合理性设计的定向进化方法，突破了底盘现有合成能力的上限（Biotechnol Biofuels 2018；ZL201710307928.8）；重新注释了全局性调控靶点YPL062W，设计了靶标高产多数萜烯类物质的酵母菌株启动子保守序列缺失、置换、突变的技术方案。

《人工细胞工厂设计构建》（高等教育出版社），合成生物学专业核心课程教材，副主编，出版前

(1) Tianyu Dong, Xiao Zhou, Zheng-Jie Hou, Yujie Shu, Mingdong Yao, Zhi-Hua Liu, Jing-Sheng Cheng, Wenhai Xiao*,Ying Wang*. Multiple strategies enhance 7-dehydrocholesterol production from kitchen waste by engineered Yarrowia lipolytica. Journal of Agricultural and Food Chemistry. 2025, 73 (1):693-705.
(2) Qi Gao, Herong Wang, Mengying Shan, Fangyuan Wu, Guozhen Jiang, Mingdong Yao, Ying Wang*, Wenhai Xiao*, Ying-Jin Yuan Systematic engineering to enhance citronellol production in yeast. Journal of Agricultural and Food Chemistry. 2025, 73 (24):15189-15198.
(3) Ying Wang, Ruosi Zhang, Mingdong Yao, Wenhai Xiao*, Ying Wang*, Ying-Jin Yuan. Transcriptomic studies on the product stress response revealed that YCF1 is a beneficial factor for progesterone production in Yarrowia lipolytica. Synthetic and Systems Biotechnology. 2025, 10(4):1087-1097.
(4) Nan Wu, Mingdong Yao, Wenhai Xiao, Ying Wang*, Ying-Jin Yuan. Highly efficient synthesis of lysergic acid using engineered budding yeast. Green Chemistry 2024,26(19):10330-10343.
(5) Nan Wu, Mingdong Yao, Wenhai Xiao, Tianyu Dong, Haidi Ma, Xianli Du*, Ying Wang*, Yingjin Yuan. Modular Pathway Compartmentalization for Agroclavine Overproduction in Saccharomyces cerevisiae: ACS Synthetic Biology. 2023,12(4): 1133-1145.
(6) Ruosi Zhang, Mingdong Yao, Haidi Ma, Wenhai Xiao, Ying Wang*, Yingjin Yuan. Modular coculture to reduce substrate competition and off-target intermediates in androstenedione biosynthesis: ACS Synthetic Biology. 2023, 12(3):788-799.
(7) Xiaojing Guo, Mingdong Yao, Wenhai Xiao, Ying Wang*, Guangrong Zhao, Yingjin Yuan. Compartmentalized reconstitution of post-squalene pathway for 7-dehydrocholesterol overproduction in Saccharomyces cerevisiae. Frontiers in Microbiology, 2021, 12:663973.
(8) Boxuan Zeng, Mingdong Yao, Wenhai Xiao, Yunzi Luo, Ying Wang*, Yingjin Yuan. Endogenous 2μ plasmid editing for pathway engineering in Saccharomyces cerevisiae. Frontiers in Microbiology, 2021, 12:631462.

ZL202110467433.8; ZL202110319820.7 ; ZL202110155734.7; ZL202010597043.8; ZL202110523493.7; ZL202110708305.8; ZL202110516129.8; ZL202011352643.4; ZL201911075759.5; ZL201910308068.9; ZL201910567660.0; ZL201910236928.2;
ZL201910243448.9; ZL201710069084.8; ZL201710086073.0; ZL201710307928.8; ZL201710090101.6; ZL201710352072.6；……

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