天然气化工,新材料,石油炼制,石油化工,精细化工,生物医药

有机化学

Glycosylation;Glycosylation Mechanisms;Total Synthesis;Synthesis;GOLD;Saponins;Diabetes;Drug Optimization;Drug Therapy/hypolipidemic Drugs;Sphingosine-1-phosphate

(1) B. Yu,* Gold (I)-catalyzed glycosylation with glycosyl o-alkynylbenzoates as donors. Acc. Chem. Res. 2018, 51, 507–516.

(2) B. Yu,* J. Sun, X. Yang, Assembly of naturally occurring glycosides, evolved tactics, and glycosylation methods. Acc. Chem. Res. 2012, 45, 1227–1236.

(3) D. Zhu, B. Yu,* Synthesis of the diverse glycosides in Traditional Chinese Medicine. Chin. J. Chem. 2018, 36, 681–691.

(4) X. Chen, X. Shao, W. Li, X. Zhang, B. Yu,* Total synthesis of Echinoside A, a representative triterpene glycoside of sea cucumbers. Angew. Chem. Int. Ed. 2017, 56, 7648–7652.

(5) X. Zhang, Y. Zhou, J. Zuo, B. Yu,* Total synthesis of Periploside A, a unique pregnane hexasaccharide with potent immunosuppressive effects. Nature Commun. 2015, 6:5879.

(6) S. Nie, W. Li, B. Yu,* Total synthesis of nucleoside antibiotic A201A. J. Am. Chem. Soc. 2014, 136, 4157–4160.

(7) Y. Tang, J. Li, Y. Zhu, Y. Li, B. Yu,* Mechanistic insights into the gold(I)-catalyzed activation of glycosyl ortho-alkynylbenzoates for glycosidation. J. Am. Chem. Soc. 2013, 135, 18396–18405.

(8) X. Yang, B. Fu, B. Yu,* Total synthesis of Landomycin A, a potent antitumor angucycline antibiotic. J. Am. Chem. Soc. 2011, 133, 12433–12435.

(9) C. Zhu, P. Tang, B. Yu,* Total synthesis of Lobatoside E, a potent antitumor cyclic triterpene saponin. J. Am. Chem. Soc. 2008, 130, 5872–5873.

(10) B. Yu,* H. Tao, Glycosyl trifluoroacetimidates. Part I: Preparation and application as new glycosyl donors. Tetrahedron Lett. 2001, 42, 2405–2407

1. Recent Advances in the Chemical Synthesis of C-Glycosides.
You Yang; Biao Yu
CHEMICAL REVIEWS, 2017

2. ChemInform Abstract: Glycosyl Trifluoroacetimidates. Part 1. Preparation and Application As New Glycosyl Donors.
Biao Yu; Houchao Tao
, 2001

3. Glycosyl Trifluoroacetimidates. Part 1: Preparation and Application As New Glycosyl Donors
B Yu; HC Tao
TETRAHEDRON LETTERS, 2001

4. An Efficient Glycosylation Protocol with Glycosyl Ortho-Alkynylbenzoates As Donors under the Catalysis of Ph3PAuOTf
Yao Li; You Yang; Biao Yu
ChemInform, 2008

5. Gold(I)-Catalyzed Glycosylation with Glycosyl O-Alkynylbenzoates As Donors.
Biao Yu
ACCOUNTS OF CHEMICAL RESEARCH, 2018

6. Thioglycosides in Carbohydrate Research
Gaoyan Lian; Xiaheng Zhang; Biao Yu
Carbohydrate Research, 2015

7. Effects of Polyphyllin D, a Steroidal Saponin in Paris Polyphylla, in Growth Inhibition of Human Breast Cancer Cells and in Xenograft.
MS Lee; JC Yuet-Wa; SK Kong; B Yu; VO Eng-Choon; HW Nai-Ching; TM Chung-Wai; KP Fung
Cancer Biology & Therapy, 2005

8. Gold(I)-catalyzed Glycosylation with Glycosyl Ortho-Alkynylbenzoates As Donors: General Scope and Application in the Synthesis of a Cyclic Triterpene Saponin.
Yao Li; Xiaoyu Yang; Yunpeng Liu; Cunsheng Zhu; You Yang; Biao Yu
CHEMISTRY-A EUROPEAN JOURNAL, 2010

9. Polyphyllin D is a Potent Apoptosis Inducer in Drug-Resistant HepG2 Cells.
JYN Cheung; RCY Ong; YK Suen; V Ooi; HNC Wong; TCW Mak; KP Fung; B Yu; SK Kong
Cancer Letters, 2004

10. First Total Synthesis of an Exceptionally Potent Antitumor Saponin, OSW-1
Sj Deng; B Yu; Y Lou; Yz Hui
JOURNAL OF ORGANIC CHEMISTRY, 1999

1. 一种艾曲波帕的用途
中国科学院上海有机化学研究所
王婧; 房鹏飞; 俞飚; 林雨绮; 徐鹏; 石富春
公开日期: 2024-07-05 申请日期: 2023-01-04 公开号: CN118286210A

2. 一种用于治疗脑水肿的化合物
复旦大学; 中国科学院上海有机化学研究所
党永军; 俞飚; 王瑞娜; 裴成锋; 蒋维; 徐鹏; 李增霞; 朱蒂
公开日期: 2023-05-12 申请日期: 2021-11-11 公开号: CN116098910A

3. GLUCOSE TRIPTOLIDE CONJUGATES AND USES THEREOF
The Johns Hopkins University; Shanghai Institute of Organic Chemistry Chinese Academy of Sciences
MARTIN GILBERT POMPER; BIAO YU; JUN O. LIU; EMMANUEL DATAN; IL MINN; PENG XU
公开日期: 2023-05-04 申请日期: 2021-03-02 公开号: US20230134986A1

4. 葡萄糖雷公藤甲素缀合物及其用途
约翰霍普金斯大学; 中国科学院上海有机化学研究所
刘钧; 伊曼纽尔·达坦; 马丁·吉尔伯特·波姆珀; 伊尔·米恩; 徐鹏; 俞飚
公开日期: 2023-02-24 申请日期: 2021-03-02 公开号: CN115715201A

5. GLUCOSE TRIPTOLIDE CONJUGATES AND USES THEREOF
The Johns Hopkins University; Shanghai Institute of Organic Chemistry Chinese
Academy of Sciences
LIU Jun O.; MINN Il; YU Biao; DATAN Emmanuel; POMPER Martin Gilbert; XU Peng
公开日期: 2023-01-11 申请日期: 2021-03-02 公开号: EP4114468A1

6. 一种用于抑制赖氨酰tRNA合成酶的芳香环类化合物
中国科学院上海有机化学研究所
房鹏飞; 周金通; 王婧; 俞飚
公开日期: 2022-09-27 申请日期: 2021-03-23 公开号: CN115109034A

7. 葡萄糖醛酸糖苷类化合物、其制备方法及应用
百极优棠（广东）医药科技有限公司
俞飚; 徐鹏; 魏炳成; 石富春
公开日期: 2022-06-21 申请日期: 2021-12-16 公开号: CN114644678A

8. 葡萄糖醛酸糖苷类化合物、其制备方法及应用
百极优棠（广东）医药科技有限公司
俞飚; 徐鹏; 魏炳成; 石富春
公开日期: 2022-06-21 申请日期: 2021-12-16 公开号: CN114644679A

9. 孕甾皂苷P57及其衍生物的中间体、制备方法和用途、及孕甾皂苷P57衍生物
中国科学院上海有机化学研究所; 复旦大学
俞飚; 张夏衡; 陈小平; 王瑞娜; 李增霞; 徐鹏; 党永军; 蒋维; 刘超; 裴成锋; 马君君; 马玉勇
公开日期: 2022-02-22 申请日期: 2020-08-20 公开号: CN114075261A

10. 一种甘露糖醛酸寡糖的制备方法及其中间体
中国科学院上海有机化学研究所
俞飚; 邵笑飞; 徐鹏
公开日期: 2021-10-22 申请日期: 2020-04-22 公开号: CN113527374A

11. Use of aromatic ring drug in inhibiting key transcription factor of malignant melanoma
SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY CHINESE ACADEMY OF SCIENCES
Jing Wang; Biao Yu; Pengfei Fang; Min Guo
公开日期: 2021-08-03 申请日期: 2018-06-04 公开号: US11077097B2

12. 一种芳香环类化合物用于抑制赖氨酰tRNA合成酶的用途
SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY CHINESE ACADEMY OF SCIENCES
FANG PENGFEI; WANG JING; ZHOU JINTONG; YU BIAO
公开日期: 2021-07-20 申请日期: 2020-01-16 公开号: CN113135894A

13. GLUCOSE CONJUGATES OF TRIPTOLIDE, ANALOGS AND USES THEREOF
The Johns Hopkins University; Shanghai Institute of Organic Chemistry Chinese Academy of Sciences
JUN LIU; QINGLI HE; MARTIN G. POMPER; IL MINN; BIAO YU; QIAOLING WANG
公开日期: 2020-09-24 申请日期: 2020-06-11 公开号: US20200297693A1

14. RETINOID COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATES THEREOF AND APPLICATION THEREOF
SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY CHINESE ACADEMY OF SCIENCES; HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Junwei CHEN; Xin CAO; Biao YU; Ning WANG
公开日期: 2020-07-09 申请日期: 2020-01-02 公开号: US20200216407A1

15. Glucose conjugates of triptolide, analogs and uses thereof
The Johns Hopkins University; Shanghai Institute of Organic Chemistry Chinese Academy of Sciences
Jun Liu; Qingli He; Martin G. Pomper; Il Minn; Biao Yu; Qiaoling Wang
公开日期: 2020-06-30 申请日期: 2017-02-03 公开号: US10695319B2

16. USE OF AROMATIC RING DRUG IN INHIBITING KEY TRANSCRIPTION FACTOR OF MALIGNANT MELANOMA
SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY CHINESE ACADEMY OF SCIENCES
Biao YU; Jing WANG; Min GUO; Pengfei FANG
公开日期: 2020-04-30 申请日期: 2018-06-04 公开号: US20200129490A1

17. Retinoid compound, preparation method therefor, intermediates thereof and application thereof
SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY CHINESE ACADEMY OF SCIENCES; HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Xin Cao; Biao Yu; Ning Wang; Junwei Chen
公开日期: 2020-02-11 申请日期: 2017-01-20 公开号: US10556879B2

18. RETINOID COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATES THEREOF AND APPLICATION THEREOF
SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY CHINESE ACADEMY OF SCIENCES; HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Xin CAO; Biao YU; Ning WANG; Junwei CHEN
公开日期: 2019-03-28 申请日期: 2017-01-20 公开号: US20190092744A1

19. GLUCOSE CONJUGATES OF TRIPTOLIDE, ANALOGS AND USES THEREOF
The Johns Hopkins University
Jun Liu; Qingli He; Martin G. Pomper; Ii Minn; Biao Yu; Qiaoling Wang
公开日期: 2019-02-07 申请日期: 2017-02-03 公开号: US20190038596A1

20. RETINOID COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATES THEREOF AND APPLICATION THEREOF
SHANGHAI INST OF ORGANIC CHEMISTRY CHINESE ACADEMY OF SCIENCES; HUAZHONG UNIV OF SCIENCE AND TECHNOLOGY
CAO XIN; YU BIAO; WANG NING; CHEN JUNWEI
公开日期: 2019-01-16 申请日期: 2017-01-20 公开号: EP3428155A1

1. 肝素类寡糖的合成及肝素酶识别底物的研究
立项时间: 2010-2013 项目经费：1100000

2. 糖基转移酶抑制剂衣霉素(Tunicamycin)的全合成和多样性合成研究
立项时间: 2014-2017 项目经费：900000

3. 肝素酶抑制剂的研究
立项时间: 2006-2008 项目经费：400000

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