生物医药

以结构生物学为主要手段，紧密结合新药研发，研究核受体、脂代谢、膜运输相关蛋白的生理功能和调控的分子机制，为设计小分子药物提供分子水平上的模板。

1. Zhao M#; Wang N#; Guo Y#; Li J; Yin Y; Dong Y; Zhu J; Peng C; Xu T*; Liu J*; Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXRα heterodimer, Proc Natl Acad Sci U S A, 2022, 119(49): e2206737119.
2. Feng B#; Chen Z#; Sun J#; Xu T#; Wang Q; Yi H; Niu X; Zhu J; Fan M; Hou R; Shao Y; Huang S; Li C; Hu P; Zheng P; He P; Luo J; Yan Q; Xiong X; Liu J*; Zhao J*; Chen L*; A Class of Shark‐Derived Single‐Domain Antibodies can Broadly Neutralize SARS‐Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape, Small methods, 2022, 6(7): e2200387.
3. Xu T#; Gan Q#; Liu Q; Chen R; Zhen X; Zhang C; Liu J*; Substrate-induced dimerization of elaiophylin glycosyltransferase reveals a novel self-activating form of glycosyltransferase for symmetric glycosylation, Acta Crystallographica Section D Structural Biology, 2022, 78(10): 1235-1248.
4. Xu T*, Gan Q, Wu B, Yin M, Xu J, Shu X, Liu J*. Molecular Basis for PI(3,5)P2 Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation. J Mol Biol 2020, 432(16): 4750-4761.
5. Hou S, Zhang Y, Xu J, Bai J, Liu J, Xie J*, Xu T*. Residue Asn21 acts as a switch for calcium binding to modulate the enzymatic activity of human phospholipase A2 group IIE. Biochimie 2020, 176: 117-121.
6. Xu T, Zhou CZ, Xiao J*, Liu J*. Unique Conformation in a Natural Interruption Sequence of Type XIX Collagen Revealed by Its High-Resolution Crystal Structure. Biochemistry 2018, 57(7): 1087-1095.
7. Wang SR#, Xu T#, Deng K, Wong CW, Liu J, Fang WS*. Discovery of Farnesoid X Receptor Antagonists Based on a Library of Oleanolic Acid 3-O-Esters through Diverse Substituent Design and Molecular Docking Methods. Molecules 2017, 22(5): 690.
8. Su K#, Xu T#, Yu Z, Zhu J, Zhang Y, Wu M, Xiong Y, Liu J, Xu J*. Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain. FEBS Lett 2017, 591(13): 2011-2018.
9. Xu T, Xu J, Ye Y, Wang Q, Shu X, Pei D, Liu J*. Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis. Proteins 2014, 82(12): 3483-3489.
10. Xu T#, Liu L#, Hou S, Xu J, Yang B, Wang Y*, Liu J*. Crystal structure of a mono- and diacylglycerol lipase from Malassezia globosa reveals a novel lid conformation and insights into the substrate specificity. J Struct Biol 2012, 178(3): 363-369.

1. 国家自然科学基金青年基金，“人源Group IIE分泌型磷脂酶A2蛋白的结构生物学研究” (31300670)，2014-2016，主持。
2. 中国科学院青年创新促进会会员（2021年）。
3. 广东省基础与应用基础研究基金青年提升项目（2023年）。
4. 广东省基础与应用基础研究基金省企联合项目（2022年）。